Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lauren Schilling"'
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 4, Pp 100528- (2024)
Objective: To further our understanding of the role of tumor necrosis factor (TNF)α on the inflammatory response in chondrocytes. Design: We explored the effects of TNFα on the transcriptome of epiphyseal chondrocytes from newborn C57BL/6 mice at t
Externí odkaz:
https://doaj.org/article/106197f5527e4491bbeb6c41005a7501
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Notch receptors are determinants of cell fate and function, and play an important role in the regulation of bone development and skeletal remodeling. Lateral Meningocele Syndrome (LMS) is a monogenic disorder associated with NOTCH3 pathogenic variant
Externí odkaz:
https://doaj.org/article/905ef0c0df8b4b55a38bde93f5dca455
Publikováno v:
J Cell Physiol
The present study defines the function of nuclear factor of activated T cells (NFAT)c1 and NFATc2 in osteoblast function in vivo and in vitro. Nfatc1loxP/loxP , Nfatc2loxP/loxP , and Nfatc1loxP/loxP ;Nfatc2loxP/loxP conditional mice were mated with B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ddefdc6655b0a67ec459a49e0f00ff
https://doi.org/10.1002/jcp.29696
https://doi.org/10.1002/jcp.29696
Publikováno v:
J Cell Physiol
Lateral meningocele syndrome (LMS), a genetic disorder characterized by meningoceles and skeletal abnormalities, is associated with NOTCH3 mutations. We created a mouse model of LMS (Notch3tm1.1Ecan ) by introducing a tandem termination codon in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dff5d6a4300c6436cf27c16f62710d
https://doi.org/10.1002/jcp.28960
https://doi.org/10.1002/jcp.28960
Publikováno v:
Journal of Biological Chemistry. 293:14165-14177
Lateral meningocele syndrome (LMS) is a rare genetic disorder characterized by neurological complications and osteoporosis. LMS is associated with mutations in exon 33 of NOTCH3 leading to a truncated protein lacking sequences for NOTCH3 degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a29fa6e11da7b389c6199e22c6197b
https://doi.org/10.1074/jbc.ra118.004242
https://doi.org/10.1074/jbc.ra118.004242
Autor:
Chris Schoenherr, Aris N. Economides, Lauren Schilling, Archana Sanjay, Jungeun Yu, Ernesto Canalis, Stefano Zanotti
Publikováno v:
The American Journal of Pathology. 188:1430-1446
Mice harboring Notch2 mutations replicating Hajdu-Cheney syndrome (Notch2(tm1.1ECan)) have osteopenia and exhibit an increase in splenic marginal zone B cells with a decrease in follicular B cells. Whether the altered B-cell allocation is responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad722690a875202430a3db36dea8d35
https://doi.org/10.1016/j.ajpath.2018.02.010
https://doi.org/10.1016/j.ajpath.2018.02.010
Publikováno v:
The Journal of Biological Chemistry
Notch2tm1.1Ecan mice, which harbor a mutation replicating that found in Hajdu–Cheney syndrome, exhibit marked osteopenia because of increased osteoclast number and bone resorption. Hairy and enhancer of split 1 (HES1) is a Notch target gene and a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32996316afcace23b97f02bbc9bf476d
https://doi.org/10.1016/j.jbc.2021.101376
https://doi.org/10.1016/j.jbc.2021.101376
Autor:
Ernesto Canalis, Stefano Zanotti, Aris N. Economides, Archana Sanjay, Jungeun Yu, Lauren Schilling, Chris Schoenherr
Publikováno v:
Journal of Biological Chemistry. 292:12232-12244
Individuals with Hajdu-Cheney syndrome (HCS) present with osteoporosis, and HCS is associated with NOTCH2 mutations causing deletions of the proline-, glutamic acid-, serine-, and threonine-rich (PEST) domain that are predicted to enhance NOTCH2 stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591ccd5f73e2a0dc1547c6f46a43b9a9
https://doi.org/10.1074/jbc.m117.786129
https://doi.org/10.1074/jbc.m117.786129
Publikováno v:
J Biol Chem
Notch receptors play critical roles in cell-fate decisions and in the regulation of skeletal development and bone remodeling. Gain–of–function NOTCH2 mutations can cause Hajdu-Cheney syndrome, an untreatable disease characterized by osteoporosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5926902044366e501c7ef332fb4eb511
https://pubmed.ncbi.nlm.nih.gov/31992595
https://pubmed.ncbi.nlm.nih.gov/31992595
Publikováno v:
Journal of Cellular Physiology. 232:363-370
Osteocytes play a fundamental role in mechanotransduction and skeletal remodeling. Sex is a determinant of skeletal structure, and female C57BL/6J mice have increased osteoblast number in cancellous bone when compared to male mice. Activation of Notc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a26e3261a1dac81dcf53ae72599d55
https://doi.org/10.1002/jcp.25433
https://doi.org/10.1002/jcp.25433