Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lauren S. Richardson"'
Autor:
Ryan C. V. Lintao, Lauren S. Richardson, Ananth Kumar Kammala, Jenieve Chapa, Dianne Aster Yunque-Yap, Kamil Khanipov, George Golovko, Leslie Michelle M. Dalmacio, Ramkumar Menon
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Chorion trophoblasts (CTCs) and immune cell-enriched decidua (DECs) comprise the maternal-fetal membrane interface called the chorio-decidual interface (CDi) which constantly gets exposed to maternal stressors without leading to labor activa
Externí odkaz:
https://doaj.org/article/a716df83141c4db2903061f745254dc0
Autor:
Mary Elise L. Severino, Lauren S. Richardson, Ananth Kumar Kammala, Enkhtuya Radnaa, Kamil Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTHuman fetal membranes (amniochorion) that line the intrauterine cavity consist of two distinct cell layers; single-layer amnion epithelial cells (AEC) and multilayer chorion trophoblast cells (CTC). These layers are connected through a collag
Externí odkaz:
https://doaj.org/article/94ae961e84de47778372be98f4f6607d
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Preterm birth rates and maternal and neonatal mortality remain concerning global health issues, necessitating improved strategies for testing therapeutic compounds during pregnancy. Current 2D or 3D cell models and animal models often f
Externí odkaz:
https://doaj.org/article/31e0bc1b54344874854f1e6c97a1f68f
Autor:
Ourlad Alzeus G. Tantengco, Lauren S. Richardson, Enkhtuya Radnaa, Ananth Kumar Kammala, Sungjin Kim, Paul Mark B. Medina, Arum Han, Ramkumar Menon
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
This study determined if exosomes from ectocervical epithelial (ECTO) cells infected with Ureaplasma parvum (U. parvum) can carry bacterial antigens and cause inflammation at the feto-maternal interface using two organ-on-chip devices, one representi
Externí odkaz:
https://doaj.org/article/7522b19396cb4a9b9b23c5133dca2474
Autor:
Esha Ganguly, Ananth Kumar Kammala, Meagan Benson, Lauren S. Richardson, Arum Han, Ramkumar Menon
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Current intervention strategies have not been successful in reducing the risks of adverse pregnancy complications nor maternal and fetal morbidities associated with pregnancy complications. Improving pregnancy and neonatal outcomes requires a better
Externí odkaz:
https://doaj.org/article/2b4f7462c5674ab1b4a128a8e39fbbab
Autor:
Lauren S. Richardson, Ananth K. Kammala, Maged M. Costantine, Stephen J. Fortunato, Enkhtuya Radnaa, Sungjin Kim, Robert N. Taylor, Arum Han, Ramkumar Menon
Publikováno v:
Lab on a Chip. 22:4574-4592
We developed multiple microfluidic organ-on-chip (OOC) devices that represent the structure, functions, and responses of the two feto-maternal interfaces (FMis) in humans (fetal membrane [FMi-OOC] and placenta [PLA-OOC]). Generated by BioRender.
Publikováno v:
American journal of reproductive immunology (New York, N.Y. : 1989).
During gestation, the decidua is an essential layer of the maternal-fetal interface, providing immune support and maintaining inflammatory homeostasis. Although Chlamydia (C.) trachomatis is associated with adverse pregnancy outcomes the pathogenic e
Autor:
Lauren S. Richardson, Nkechinyere Emezienna, Irina Burd, Brandie D. Taylor, Morgan R. Peltier, Arum Han, Ramkumar Menon
Publikováno v:
American Journal of Reproductive Immunology. 88
Fetal neuroinflammation has been linked to preterm birth-related intraamniotic infection and inflammation; However, the contribution of fetal sex and maternal race/ethnicity is unknown. To determine if fetal sex and maternal race/ethnicity influence
Autor:
Emmanuel Amabebe, Lauren S. Richardson, Giovana Fernanda Cosi Bento, Enkhtuya Radnaa, Talar Kechichian, Ramkumar Menon, Dilly O. C. Anumba
Background Ureaplasma, a subspecies of genital Mycoplasma is one of the most common microbes isolated from women with infection/inflammation-associated preterm labor (PTL). Mycoplasma spp. produce sialidase that cleaves sialic acid from glycans of va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7338238bb1de0fc25ff818beafa63123
https://doi.org/10.21203/rs.3.rs-2041882/v1
https://doi.org/10.21203/rs.3.rs-2041882/v1
Autor:
Ourlad Alzeus G. Tantengco, Lauren S. Richardson, Enkhtuya Radnaa, Ananth Kumar Kammala, Sungjin Kim, Paul Mark B. Medina, Arum Han, Ramkumar Menon
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(10)
Genital mycoplasmas can break the cervical barrier and cause intraamniotic infection and preterm birth. This study developed a six-chamber vagina-cervix-decidua-organ-on-a-chip (VCD-OOC) that recapitulates the female reproductive tract during pregnan