Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lauren S Vaughn"'
Autor:
Sarah L. Olguin, Priyanka Patel, Courtney N. Buchanan, Michela Dell’Orco, Amy S. Gardiner, Robert Cole, Lauren S. Vaughn, Anitha Sundararajan, Joann Mudge, Andrea M. Allan, Pavel Ortinski, Jonathan L. Brigman, Jeffery L. Twiss, Nora I. Perrone-Bizzozero
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
KH-type splicing regulatory protein (KHSRP) regulates levels of several neuronal mRNAs linked to nervous system development and function.
Externí odkaz:
https://doaj.org/article/29fb0456e49249abaa4a77b4ff338e51
Autor:
Lauren S. Vaughn, Kenneth Frederick, Samuel B. Burnett, Nutan Sharma, D. Cristopher Bragg, Sarah Camargos, Francisco Cardoso, Rekha C. Patel
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 713 (2022)
DYT-PRKRA (dystonia 16 or DYT-PRKRA) is caused by mutations in the PRKRA gene that encodes PACT, the protein activator of interferon (IFN)-induced double-stranded (ds) RNA-activated protein kinase (PKR). PACT participates in several cellular pathways
Externí odkaz:
https://doaj.org/article/612dc1abaa54440db081f69acf983f34
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105135- (2020)
Dystonia 16 (DYT16) is caused by mutations in PACT, the protein activator of interferon-induced double-stranded RNA-activated protein kinase (PKR). PKR regulates the integrated stress response (ISR) via phosphorylation of the translation initiation f
Externí odkaz:
https://doaj.org/article/732b713f7bd649c4bf82bc575f29e84a
Autor:
Priyanka Patel, Courtney N Buchanan, Matthew D Zdradzinski, Pabitra K Sahoo, Amar N Kar, Seung Joon Lee, Lauren S Vaughn, Anatoly Urisman, Juan Oses-Prieto, Michela Dell’Orco, Devon E Cassidy, Irene Dalla Costa, Sharmina Miller, Elizabeth Thames, Terika P Smith, Alma L Burlingame, Nora Perrone-Bizzozero, Jeffery L Twiss
Publikováno v:
Nucleic acids research. 50(10)
Axonally synthesized proteins support nerve regeneration through retrograde signaling and local growth mechanisms. RNA binding proteins (RBP) are needed for this and other aspects of post-transcriptional regulation of neuronal mRNAs, but only a limit
Autor:
Lauren S, Vaughn, Kenneth, Frederick, Samuel B, Burnett, Nutan, Sharma, D Cristopher, Bragg, Sarah, Camargos, Francisco, Cardoso, Rekha C, Patel
Publikováno v:
Biomolecules. 12(5)
DYT
Autor:
Sarah L. Olguin, Priyanka Patel, Courtney N. Buchanan, Michela Dell’Orco, Amy S. Gardiner, Robert Cole, Lauren S. Vaughn, Anitha Sundararajan, Joann Mudge, Andrea M. Allan, Pavel Ortinski, Jonathan L. Brigman, Jeffery L. Twiss, Nora I. Perrone-Bizzozero
Publikováno v:
Communications biology. 5(1)
The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 mRNA and decrease neurite growth in cultured embryonic neurons. Here, we have te
Publikováno v:
Biochem J
An integral aspect of innate immunity is the ability to detect foreign molecules of viral origin to initiate antiviral signaling via pattern recognition receptors (PRRs). One such receptor is the RNA helicase retinoic acid inducible gene 1 (RIG-I), w
Autor:
Sankar Ghosh, Brener C. Carvalho, Dev M. Bhatt, Leonardo B. Oliveira, Lauren S. Vaughn, Dillon Maloney, Will Liao, Aristóbolo M. Silva, Felipe B. Leão
Publikováno v:
The international journal of biochemistrycell biology. 127
Ras Guanine Exchange Factor (RasGEF) domain family member 1b is encoded by a Toll-like receptor (TLR)-inducible gene expressed in macrophages, but transcriptional mechanisms that govern its expression are still unknown. Here, we have functionally cha
Autor:
Ottavio Arancio, Alice Lepelley, Peter Koppensteiner, Shirley ShiDu Yan, Hong Zhang, Lauren S. Vaughn, Ipe Ninan, Sankar Ghosh, Fang Du, Andrew F. Teich, Zeljko Tomljanovic, Flávia R.G. Carneiro, Matthew S. Hayden, Thomas S. Postler, Agnieszka Staniszewski
Altered mitochondrial fitness is a potential triggering factor in Alzheimer’s disease (AD). Mitochondrial quality control pathways are dysfunctional and mitochondrially-derived reactive oxygen species (mROS) levels are increased in AD patient brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9884ba26a845131c0326b81815cec1e
Publikováno v:
Neurobiology of Disease, Vol 146, Iss, Pp 105135-(2020)
Dystonia 16 (DYT16) is caused by mutations in PACT, the protein activator of interferon-induced double-stranded RNA-activated protein kinase (PKR). PKR regulates the integrated stress response (ISR) via phosphorylation of the translation initiation f