Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lauren S, Levine"'
Autor:
Zoe Quandt, Saya Jacob, Muhammad Zaki Hidayatullah Fadlullah, Chaorong Wu, Clinton Wu, Laura Huppert, Lauren S. Levine, Paula Sison, Katy K. Tsai, Melissa Chow, Jee Hye Kang, Jimmy Hwang, James C. Lee, Ariel Oglesby, Jessica Venegas, Ben J. Brintz, Aik Choon Tan, Mark S. Anderson, Michael D. Rosenblum, Arabella Young, Adil I. Daud
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Objective Many patients with melanoma treated with immune checkpoint inhibitors (ICIs) do not derive response. Preclinical and retrospective studies identified that inhibition of the cyclooxygenase (COX) pathway may improve response to ICI t
Externí odkaz:
https://doaj.org/article/c105ad53a05b4e0fa71f9d23c963083c
Autor:
Eun Ji Kim, Barzin Y Nabet, Nam Woo Cho, Sophia M Guldberg, Kamir J Hiam-Galvez, Jacqueline L Yee, Rachel DeBarge, Katherine Wai, Lauren S Levine, Naa Asheley Ashitey, Matthew H Spitzer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/cb45a473c48947488bcd1bc7a6259a51
Autor:
Nam Woo Cho, Sophia M. Guldberg, Eun Ji Kim, Kamir J. Hiam-Galvez, Katherine Wai, Lauren S. Levine, Barzin Y. Nabet, Rachel DeBarge, Jacqueline L. Yee, Naa Asheley Ashitey, Iliana Tenvooren, Matthew H. Spitzer
Even in patients whose tumours exhibit increased T cell infiltration, resistance to immune checkpoint inhibitor (ICI) therapy is common. We investigated mechanisms of ICI resistance using engineered mouse models with increased neoantigen burden and T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb603281f9788dc9e6c4674727a9aaf6
https://doi.org/10.1101/2022.09.20.508732
https://doi.org/10.1101/2022.09.20.508732
Autor:
James Lee, Michael Alvarado, Kelly M. Mahuron, Clinton Wu, Katy K. Tsai, Arielle Oglesby, Michael Rosenblum, Lauren S. Levine, Mariela L. Pauli, Daiva M. Mattis, Adil Daud, Alain Algazi, Matthew H. Spitzer, Matthew F. Krummel
Publikováno v:
Annals of surgical oncology, vol 27, iss 11
Ann Surg Oncol
Ann Surg Oncol
BACKGROUND. The frequency of "exhausted" or check-point-positive (PD-1(+)CTLA-4(+)) cytotoxic lymphocytes (Tex) in the tumor microenvironment is associated with response to anti-PD-1 therapy in metastatic melanoma. The current study determined whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f9c2d0ab8f6035bb5ac98671bc3c57
https://escholarship.org/uc/item/2tv559t6
https://escholarship.org/uc/item/2tv559t6
Publikováno v:
Annals of surgical oncology, vol 27, iss 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4f4327affd3e733ba41a63e9130454
https://escholarship.org/uc/item/46b459t3
https://escholarship.org/uc/item/46b459t3
Autor:
Lauren S, Levine, Kamir J, Hiam-Galvez, Diana M, Marquez, Iliana, Tenvooren, Matthew Z, Madden, Diana C, Contreras, Debolanle O, Dahunsi, Jonathan M, Irish, Olalekan O, Oluwole, Jeffrey C, Rathmell, Matthew H, Spitzer
Publikováno v:
Immunity. 54(4)
Memory T cells are thought to rely on oxidative phosphorylation and short-lived effector T cells on glycolysis. Here, we investigated how T cells arrive at these states during an immune response. To understand the metabolic state of rare, early-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::838ce10a40f522ec8c888b8abf20421f
https://pubmed.ncbi.nlm.nih.gov/33852827
https://pubmed.ncbi.nlm.nih.gov/33852827
Publikováno v:
Annals of surgical oncology. 27(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6edcb357cd718964d11754c004b51c8
https://pubmed.ncbi.nlm.nih.gov/32488511
https://pubmed.ncbi.nlm.nih.gov/32488511
Autor:
Iliana Tenvooren, Lauren S. Levine, Diana M. Marquez, Kamir J. Hiam, Jeffrey C. Rathmell, Diana C. Contreras, Matthew H. Spitzer
Memory T cells conventionally rely on oxidative phosphorylation and short-lived effector T cells on glycolysis. Here, we investigate how T cells arrive at these states during an immune response. In order to understand the metabolic state of rare, ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab8dc4a1e36ef9a8e01fd9dda868abd
https://doi.org/10.1101/2020.01.21.911545
https://doi.org/10.1101/2020.01.21.911545
Autor:
Iliana Tenvooren, Jonathan M. Irish, Diana C. Contreras, Jeffrey C. Rathmell, Debolanle O. Dahunsi, Lauren S. Levine, Diana M. Marquez, Kamir J Hiam-Galvez, Olalekan O. Oluwole, Matthew Z. Madden, Matthew H. Spitzer
Publikováno v:
Immunity. 54:829-844.e5
Summary Memory T cells are thought to rely on oxidative phosphorylation and short-lived effector T cells on glycolysis. Here, we investigated how T cells arrive at these states during an immune response. To understand the metabolic state of rare, ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf5db5c53151a134a4d7e886a9f1eb6
https://doi.org/10.1016/j.immuni.2021.02.018
https://doi.org/10.1016/j.immuni.2021.02.018
Autor:
James Lee, Lawrence Chen, Miguel Hernandez Pampaloni, Matthew F. Krummel, Michael Rosenblum, Kimberly Loo, Kelly M. Mahuron, Lauren S. Levine, Adil Daud, Katy K. Tsai, Mariela L. Pauli, Priscila Munoz Sandoval, Adi Nosrati, Alain Algazi, Michael Alvarado, Jimmy Hwang, Jacqueline Liu
Publikováno v:
JCI insight, vol 2, iss 14
Background Programmed death 1 (PD-1) inhibition activates partially exhausted cytotoxic T lymphocytes (peCTLs) and induces tumor regression. We previously showed that the peCTL fraction predicts response to anti-PD-1 monotherapy. Here, we sought to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c3fde50d50e56f134ef07127dccae1
https://doi.org/10.1172/jci.insight.93433
https://doi.org/10.1172/jci.insight.93433