Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lauren R. Devine"'
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100506- (2024)
Diacylglycerol kinases (DGKs) are lipid kinases that mediate the phosphorylation of diacylglycerol (DAG) leading to the production of phosphatidic acid (PtdOH). To examine the role of phosphorylation on DGK-θ, we first identified the phosphorylated
Externí odkaz:
https://doaj.org/article/f294b9b9fb124944bbd1538a6eac8eed
Autor:
Casey N. Barber, Hana L. Goldschmidt, Qianqian Ma, Lauren R. Devine, Robert N. Cole, Richard L. Huganir, Daniel M. Raben
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling. One such enzyme is diacylglycerol kinase θ (DGKθ), which produces phosphatidic ac
Externí odkaz:
https://doaj.org/article/d917949188d14b47ab204855869a0636
Autor:
John L. Goodier, Alisha O. Soares, Gavin C. Pereira, Lauren R. DeVine, Laura Sanchez, Robert N. Cole, Jose Luis García-Pérez
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-23 (2020)
Abstract A pathogenic GGGCCC hexanucleotide expansion in the first intron/promoter region of the C9orf72 gene is the most common mutation associated with amyotrophic lateral sclerosis (ALS). The C9orf72 gene product forms a complex with SMCR8 (Smith-
Externí odkaz:
https://doaj.org/article/cee7ada86f764b7db8a084eff5bd3416
Autor:
Gaelle Noel, Julie G. In, Jose M. Lemme-Dumit, Lauren R. DeVine, Robert N. Cole, Anthony L. Guerrerio, James D. Campbell, Olga Kovbasnjuk, Marcela F. Pasetti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Breastfeeding has been associated with long lasting health benefits. Nutrients and bioactive components of human breast milk promote cell growth, immune development, and shield the infant gut from insults and microbial threats. The molecular and cell
Externí odkaz:
https://doaj.org/article/8db1528c7b484bdfa5eb022dd3ec1bb2
Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation
Autor:
Xi Liu, John M. Abraham, Yulan Cheng, Zhixiong Wang, Zhe Wang, Guanjun Zhang, Hassan Ashktorab, Duane T. Smoot, Robert N. Cole, Tatiana N. Boronina, Lauren R. DeVine, C. Conover Talbot, Jr., Zhengwen Liu, Stephen J. Meltzer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 312-321 (2018)
MicroRNA (miR) sponges containing miR binding sequences constitute a potentially powerful molecular therapeutic strategy. Recently, naturally occurring circular RNAs (circRNAs) were shown to function as efficient miR sponges in cancer cells. We hypot
Externí odkaz:
https://doaj.org/article/6d47a7e65b7f47b8a66999a33eaf703f
Autor:
Chelsy R Eddings, Ernest Fraenkel, Mali Jiang, C. Conover Talbot, Paul T. Ranum, Lauren R. DeVine, Robert N. Cole, Emma Whelan, Anthony Tang, Amanda J. Kedaigle, Leonard O Marque, Beverly L. Davidson, Ronald Wang, Nicolas Arbez, Tamara Ratovitski, Christopher A. Ross, Sergey S Akimov
Publikováno v:
Prof. Fraenkel
Hum Mol Genet
Hum Mol Genet
We have previously established induced pluripotent stem cell (iPSC) models of Huntington’s disease (HD), demonstrating CAG-repeat-expansion-dependent cell biological changes and toxicity. However, the current differentiation protocols are cumbersom
Autor:
Pavan S. Krishnan, Fernando T. Zamuner, Carolyn M. Jenks, Yanjun Xie, Lisa Zhang, Mohammed Lehar, Marcos Iglesias Lozano, Neal S. Fedarko, Lauren R. DeVine, Mariana Brait, Robert N. Cole, John P. Carey
Calcitonin gene-related peptide (CGRP) is a vasoactive neuropeptide that plays a putative role in the pathophysiology of migraine headaches and may be a candidate for biomarker status. Here, we present a protocol for purification and quantification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8cf89c02041dab1c66396904d96d93
https://doi.org/10.17504/protocols.io.3byl4b98jvo5/v1
https://doi.org/10.17504/protocols.io.3byl4b98jvo5/v1
Autor:
Arianna F. Anzmann, Olivia L. Sniezek, Steven M. Claypool, Alexandra Pado, Lauren R. DeVine, Hilary J. Vernon, Frédéric M. Vaz, Robert N. Cole, Anne Le, Simion Kreimer, Veronica F. Busa, Brian J. Kirsch
Publikováno v:
Journal of biological chemistry, 297(3):101005. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Barth syndrome (BTHS) is an X-linked disorder of mitochondrial phospholipid metabolism caused by pathogenic variants in TAFFAZIN, which results in abnormal cardiolipin (CL) content in the inner mitochondrial membrane. To identify unappreciated pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8513153ad63be4ec2a55413a2dd75dea
https://pure.amc.nl/en/publications/diverse-mitochondrial-abnormalities-in-a-new-cellular-model-of-taffazzin-deficiency-are-remediated-by-cardiolipininteracting-small-molecules(0d7f8d5c-d63e-47b4-9cdd-35b501bb7f6b).html
https://pure.amc.nl/en/publications/diverse-mitochondrial-abnormalities-in-a-new-cellular-model-of-taffazzin-deficiency-are-remediated-by-cardiolipininteracting-small-molecules(0d7f8d5c-d63e-47b4-9cdd-35b501bb7f6b).html
Autor:
James D. Campbell, Marcela F. Pasetti, Gaelle Noel, Olga Kovbasnjuk, Robert N. Cole, Jose M. Lemme-Dumit, Anthony L. Guerrerio, Lauren R. DeVine, Julie G. In
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Breastfeeding has been associated with long lasting health benefits. Nutrients and bioactive components of human breast milk promote cell growth, immune development, and shield the infant gut from insults and microbial threats. The molecular and cell
Autor:
James P. Hamilton, Aline Gottlieb, Lauren R. DeVine, Robert N. Cole, Kathleen L. Gabrielson, Svetlana Lutsenko, Som Dev
Publikováno v:
Am J Pathol
Wilson disease (WND) is caused by inactivation of the copper transporter ATP7B and copper accumulation in tissues. WND presentations vary from liver steatosis to inflammation, fibrosis, and liver failure. Diets influence the liver phenotype in WND, b