Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lauren R. Blankenship"'
Autor:
Shuhua G. Li, Kai S. Yang, Lauren R. Blankenship, Chia-Chuan D. Cho, Shiqing Xu, Hongbin Wang, Wenshe Ray Liu
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The emergence and rapid spread of SARS-CoV-2, the pathogen of COVID-19, have caused a worldwide public health crisis. The SARS-CoV-2 main protease (Mpro) is an essential enzyme for the virus and therefore an appealing target for the development of an
Externí odkaz:
https://doaj.org/article/0f590b767e6d480e9aabae8df5814fed
Autor:
Kai S. Yang, Lauren R. Blankenship, Syuan-Ting Alex Kuo, Yan J. Sheng, Pingwei Li, Carol A. Fierke, David H. Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
ACS Chemical Biology. 18:449-455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a491594b34359dab82f6a38e3cff64b
https://doi.org/10.1021/acschembio.2c00695
https://doi.org/10.1021/acschembio.2c00695
Autor:
Kaustav Khatua, Yugendar R. Alugubelli, Kai S. Yang, Veerabhadra R. Vulupala, Lauren R. Blankenship, Demonta D. Coleman, Sandeep Atla, Sankar P. Chaki, Zhi Zachary Geng, Xinyu R. Ma, Jing Xiao, Peng-Hsun Chase Chen, Chia-Chuan Dean Cho, Erol C. Vatansever, Yuying Ma, Ge Yu, Benjamin W. Neuman, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
bioRxiv
Main protease (MPro) of SARS-CoV-2, the viral pathogen of COVID-19, is a crucial nonstructural protein that plays a vital role in the replication and pathogenesis of the virus. Its protease function relies on three active site pockets to recognize P1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216a999fb1a67e7463a682d08f991ad5
https://doi.org/10.1101/2023.04.11.536467
https://doi.org/10.1101/2023.04.11.536467
Autor:
Zhi Zachary Geng, Sandeep Atla, Namir Shaabani, Veerabhadra R. Vulupala, Kai S. Yang, Yugendar R. Alugubelli, Kaustav Khatua, Peng-Hsun Chase Chen, Jing Xiao, Lauren R. Blankenship, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
bioRxiv
SARS-CoV-2 is the coronavirus pathogen of the currently prevailing COVID-19 pandemic. It relies on its main protease (MPro) for replication and pathogenesis. MProis a demonstrated target for the development of antivirals for SARS-CoV-2. Past studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac78ca035630d56fd9f723ac192834af
https://europepmc.org/articles/PMC9882326/
https://europepmc.org/articles/PMC9882326/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2530
Proteins with a functionalized C-terminus are critical to synthesizing large proteins via expressed protein ligation. To overcome the limitations of currently available C-terminus functionalization strategies, we established an approach based on a sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d4a6ae869543258224b43df4857e568
https://pubmed.ncbi.nlm.nih.gov/35761048
https://pubmed.ncbi.nlm.nih.gov/35761048
Autor:
Yuying Ma, Kai S. Yang, Zhi Zachary Geng, Yugendar R. Alugubelli, Namir Shaabani, Erol C. Vatansever, Xinyu R. Ma, Chia-Chuan Cho, Kaustav Khatua, Jing Xiao, Lauren R. Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
European journal of medicinal chemistry. 240
As an essential enzyme of SARS-CoV-2, the COVID-19 pathogen, main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a81a516b0d37d2834e84a225268290
https://pubmed.ncbi.nlm.nih.gov/35779291
https://pubmed.ncbi.nlm.nih.gov/35779291
Autor:
Yugendar R. Alugubelli, Zhi Zachary Geng, Kai S. Yang, Namir Shaabani, Kaustav Khatua, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Jing Xiao, Lauren R. Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
European journal of medicinal chemistry. 240
Boceprevir is an HCV NSP3 inhibitor that was explored as a repurposed drug for COVID-19. It inhibits the SARS-CoV-2 main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63c3e307cea4b117f772707e5bbcdef
https://pubmed.ncbi.nlm.nih.gov/35839690
https://pubmed.ncbi.nlm.nih.gov/35839690
Autor:
Kai S. Yang, Syuan-Ting Alex Kuo, Lauren R. Blankenship, Yan J. Sheng, Banumathi Sankaran, Pingwei Li, Carol A. Fierke, David H. Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu
As the COVID-19 pathogen, SARS-CoV-2 relies on its main protease (MPro) for pathogenesis and replication. During the crystallographic analyses of MPro crystals that were exposed to the air, a uniquely Y-shaped, S-O-N-O-S-bridged posttranslational cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5747779f34ec89049b0c1a9eb60704
https://doi.org/10.1101/2022.04.29.490044
https://doi.org/10.1101/2022.04.29.490044
Publikováno v:
J Mol Biol
The amber suppression-based noncanonical amino acid (ncAA) mutagenesis technique has been widely used in both basic and applied research. So far more than two hundred ncAAs have been genetically encoded by amber codon in both prokaryotes and eukaryot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90088aaaa7312ab13fc403d47956e602
https://europepmc.org/articles/PMC9018550/
https://europepmc.org/articles/PMC9018550/
Publikováno v:
Methods in Molecular Biology ISBN: 9781071624883
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::029eb714c45cb5b6686133b2ce0b5cd9
https://doi.org/10.1007/978-1-0716-2489-0_11
https://doi.org/10.1007/978-1-0716-2489-0_11