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pro vyhledávání: '"Lauren R. Alesi"'
Autor:
Natasha D. Ratnayaka-Gamage, Lauren R. Alesi, Nadeen Zerafa, Jessica M. Stringer, Karla J. Hutt
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosi
Externí odkaz:
https://doaj.org/article/5f5fb79aac544827af9939d421f1dc2e
Autor:
Meaghan J. Griffiths, Sarah A. Marshall, Fiona L. Cousins, Lauren R. Alesi, Jordan Higgins, Saranya Giridharan, Urooza C. Sarma, Ellen Menkhorst, Wei Zhou, Alison S. Care, Jacqueline F. Donoghue, Sarah J. Holdsworth-Carson, Peter A.W. Rogers, Evdokia Dimitriadis, Caroline E. Gargett, Sarah A. Robertson, Amy L. Winship, Karla J. Hutt
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Female cancer survivors are significantly more likely to experience infertility than the general population. It is well established that chemotherapy and radiotherapy can damage the ovary and compromise fertility, yet the ability of cancer treatments
Externí odkaz:
https://doaj.org/article/ee2f5e90ec17471e8dc9f94a729ae7b3
Publikováno v:
Reproduction and Fertility, Vol 3, Iss 1, Pp 10-18 (2022)
A mouse model to study uterine specific contributions to pregnancy. Maternal environmental exposures can exert impacts on the ability of the uterus to sustain healthy pregnancy. To establish an in vivo model to study this, we designed an ovariectomiz
Externí odkaz:
https://doaj.org/article/8a944f234fd44b34a5f51cb161333525
Autor:
Amy L. Winship, Lauren R. Alesi, Sneha Sant, Jessica M. Stringer, Aldana Cantavenera, Teharn Hegarty, Carolina Lliberos Requesens, Seng H. Liew, Urooza Sarma, Meaghan J. Griffiths, Nadeen Zerafa, Stephen B. Fox, Emmaline Brown, Franco Caramia, Pirooz Zareie, Nicole L. La Gruta, Kelly-Anne Phillips, Andreas Strasser, Sherene Loi, Karla J. Hutt
Publikováno v:
Nature Cancer. 3:1-13
Loss of fertility is a major concern for female reproductive-age cancer survivors, since a common side-effect of conventional cytotoxic cancer therapies is permanent damage to the ovary. While immunotherapies are increasingly becoming a standard of c
Autor:
Meaghan J. Griffiths, Jordan N. Higgins, Fiona L. Cousins, Lauren R. Alesi, Amy L. Winship, Karla J. Hutt
Publikováno v:
Journal of Visualized Experiments.
Publikováno v:
Reproduction and Fertility. 4
Cytotoxic chemotherapies have been a mainstay of cancer treatment but are associated with numerous systemic adverse effects, including impacts on fertility and endocrine health. Irreversible ovarian damage and follicle depletion are the side effects
Publikováno v:
Human Reproduction Update.
BACKGROUNDRegulated cell death is a fundamental component of numerous physiological processes; spanning from organogenesis in utero, to normal cell turnover during adulthood, as well as the elimination of infected or damaged cells throughout life. Qu
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 18:15-28
Ovarian damage, resulting in oocyte death, loss of endocrine function and infertility, is a well-documented side effect of many traditional, cytotoxic cancer therapies. However, the landscape of cancer therapies is rapidly changing. Women are now als
Publikováno v:
Reproductionfertility. 3(1)
A mouse model to study uterine specific contributions to pregnancy.Maternal environmental exposures can exert impacts on the ability of the uterus to sustain healthy pregnancy. To establish anMany pregnancy complications occur because of problems in
Publikováno v:
Journal of Visualized Experiments.
Sexually reproducing female mammals are born with their entire lifetime supply of oocytes. Immature, quiescent oocytes are found within primordial follicles, the storage unit of the female germline. They are non-renewable, thus their number at birth