Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lauren Pepper"'
Autor:
Amanda Hanson, Kutlu Elpek, Ellen Duong, Lindsey Shallberg, Martin Fan, Calvin Johnson, Matthew Wallace, George R Mabry, Stephen Sazinsky, Lauren Pepper, Chengyi J Shu, Sriram Sathyanarayanan, Sarah Zuerndorfer, Tyler Simpson, Monica Gostissa, Michael Briskin, Deborah Law, Jennifer Michaelson, Christopher J Harvey
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239595 (2020)
Immunotherapy checkpoint inhibitors, such as antibodies targeting PD-1 and CTLA-4, have demonstrated the potential of harnessing the immune system to treat cancer. However, despite encouraging results particularly with respect to survival, only a min
Externí odkaz:
https://doaj.org/article/12342d258a3a4c9696b7dad685961d58
Autor:
Ben Umiker, Yasmin Hashambhoy-Ramsay, Jeff Smith, Tanzila Rahman, Amy Mueller, Rachel Davidson, Christina Meyer, Gayatri Patankar, Mohammad Murshid Alam, Sarah Jaffe, Kristin Krukenberg, Allison Goodman, Vikki Spaulding, Michelle Priess, Abha Dhaneshwar, Masie Wong, Alexa Diiorio, Kristin O'Malley, Lara McGrath, Margaret Willer, Lauren Pepper, Monica Gostissa, Katalin Kis-Toth, Dmitri Wiederschain, Heather Cohen, Donald R. Shaffer
Publikováno v:
Molecular Cancer Therapeutics. 22:471-484
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdc9ed87146b6d569a16703ed901dc0f
https://doi.org/10.1158/1535-7163.mct-22-0351
https://doi.org/10.1158/1535-7163.mct-22-0351
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Sensitivity of LILRB2 as a predictive biomarker for pharmacodynamic response as measured by the macrophage polarization score in histoculture explant cultures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7300803b6c2959ff55929ff818f38977
https://doi.org/10.1158/1535-7163.22551994.v1
https://doi.org/10.1158/1535-7163.22551994.v1
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e89f1a6392cc21d33474e1853be7817
https://doi.org/10.1158/1535-7163.c.6534805.v1
https://doi.org/10.1158/1535-7163.c.6534805.v1
Autor:
Christina Chaivorapol, Chamith Fonseka, Terry J. Fry, Shirisha Amatya, Zach Frye, Saurabh Paliwal, Jagesh V Shah, Samantha Davis, Patricia Cruite, Christopher Bandoro, Hina Iftikhar, Nikolas Balanis, Michael Laska, Lauren Pepper
Publikováno v:
Blood. 138:3983-3983
Introduction: The ability to deliver genes to specific cell types in vivo would have a profound therapeutic impact for a diverse set of diseases. For example, targeting T cells for in vivo delivery of a chimeric antigen receptor (CAR) to treat B cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e0369233ad2f653cfce37fdbb546ce
https://doi.org/10.1182/blood-2021-149990
https://doi.org/10.1182/blood-2021-149990
Autor:
Heather Jewell, Akinola Olumide Emmanuel, Albert Ruzo, Boris Gorovits, Caspian Harding, Bindu Varghese, Yonatan Lipsitz, Vidur Patel, Justine Cunningham, Sundeep Chandra, Victoria Duback, Hemant Chavan, Joohwan Kim, Michelle Nguyen-McCarty, Shannon Joyce, Aaron E. Foster, Carmela Passaro, Sergey Lyubinetsky, Lauren Pepper, Jason Rodriguez, Trevor McGill, Kelan Hlavaty, Misha Shamashkin, Paige Baldwin, Terry J. Fry, Shirisha Amatya, Carl Co, Salvatore Iovino, Jagesh V Shah, Hanane Ennajdaoui, Jess Elman, Allyse Mazzarelli, Donna Dambach, Kutlu G. Elpek, Carrie Rocca, Vasily Vagin, James Kaczmarek, Pattie Cruite, Michael Laska
Publikováno v:
Blood. 138:2769-2769
Introduction: Ex vivo manufactured chimeric antigen receptor (CAR) T cell therapies are highly effective for treating B cell malignancies. However, the complexity, cost and time required to manufacture CAR T cells limits access. To overcome conventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46946ed5099ec17431d5555f68d3aae8
https://doi.org/10.1182/blood-2021-148709
https://doi.org/10.1182/blood-2021-148709
Autor:
Sergey Lyubinetsky, Allyse Mazarelli, Jess Elman, Kutlu G. Elpek, Patty Cruite, Caspian Harding, Trevor McGill, Donna Dambach, Terry J. Fry, Salvatore Iovino, Carmela Passaro, Vidur Patel, Shirisha Amatya, Albert Ruzo, Kelan Hlavaty, Victoria Duback, Lauren Pepper, Anna Liang, Avani Parikh, Akinola Olumide Emmanuel, Jagesh V Shah, Samantha Crocker, Michael Laska, Jason Rodriguez, Hanane Ennajdaoui, Paige Baldwin
Publikováno v:
Cancer Research. 81:LB105-LB105
CAR T cells are highly effective at inducing remissions in patients with refractory B cell malignancies. The ex vivo process used to manufacture these therapies limits patient access and exposes T cells to non-physiologic conditions in culture. Viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9060fe6670dabb0084870caeaeacae6e
https://doi.org/10.1158/1538-7445.am2021-lb105
https://doi.org/10.1158/1538-7445.am2021-lb105
Autor:
George Robert Mabry, Christopher Harvey, Matthew Wallace, Ellen Duong, Lauren Pepper, Michael Briskin, Jennifer S. Michaelson, Calvin Johnson, Kutlu G. Elpek, Amanda Hanson, Martin Fan, Tyler R. Simpson, Deborah Law, Monica Gostissa, Sarah Zuerndorfer, Lindsey Shallberg, Stephen Sazinsky, Chengyi J. Shu, Sriram Sathyanarayanan
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239595 (2020)
PLoS ONE
PLoS ONE
Immunotherapy checkpoint inhibitors, such as antibodies targeting PD-1 and CTLA-4, have demonstrated the potential of harnessing the immune system to treat cancer. However, despite encouraging results particularly with respect to survival, only a min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bc9d9f19bc5853a9bc59f25e18b14a
https://doi.org/10.1371/journal.pone.0239595
https://doi.org/10.1371/journal.pone.0239595