Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lauren P Liu"'
Autor:
Tamim Kawakibi, Niharika Bala, Lauren P. Liu, Louis A. Searcy, Nancy D. Denslow, Abdel A. Alli
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1489 (2023)
Cathpesin B is a multi-functional protease that plays numerous roles in physiology and pathophysiology. We hypothesized that actin cytoskeleton proteins that are substrates of cathepsin B, various lipids, and kinases that are regulated by lipids woul
Externí odkaz:
https://doaj.org/article/dbd96dc1e0234321a07b9a0d67f7c580
Autor:
Yogesh M. Scindia, Mohammed F. Gholam, Alina Waleed, Lauren P. Liu, Kevin M. Chacko, Dhruv Desai, Juliana Pena Lopez, Zeeshan Malik, Whitney C. Schramm, Angelica G. Morales, Morgan Carson-Marino, Abdel A. Alli
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 305 (2023)
Diabetic nephropathy is the primary cause of morbidity in type 2 diabetes mellitus (T2DM) patients. New data indicate that hypertension, a common comorbidity in T2DM, can worsen outcomes of diabetic nephropathy. While metformin is a commonly prescrib
Externí odkaz:
https://doaj.org/article/7fcb29cb8c8f465bab7cddaaa2531bef
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1408 (2023)
In addition to inhibiting renal glucose reabsorption and allowing for glucose excretion, the sodium/glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin may be efficacious in treating various comorbidities associated with type 2 diabetes mellitus
Externí odkaz:
https://doaj.org/article/a2ccd9946a0c495b87bf67385e93a810
Autor:
Sara Darwish, Lauren P. Liu, Tanya O. Robinson, Spurthi Tarugu, Anna H. Owings, Sarah C. Glover, Abdel A. Alli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1654 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the causative agent of the COVID-19 disease. COVID-19 viral infection can affect many cell types, including epithelial cells of the lungs and airways. Extracellular vesicles (EVs)
Externí odkaz:
https://doaj.org/article/5330185302864705a91a1bbee244f13e
Autor:
Carlos I. Lugo, Lauren P. Liu, Niharika Bala, Angelica G. Morales, Mohammed F. Gholam, Julia C. Abchee, Nasseem Elmoujahid, Ahmed Samir Elshikha, Rigena Avdiaj, Louis A. Searcy, Nancy D. Denslow, Sihong Song, Abdel A. Alli
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 66 (2022)
Hypertension may develop before or after the onset of diabetes and it is known to increase the risk of developing diabetic nephropathy. Alpha-1 antitrypsin (AAT) is a multi-functional protein with beneficial effects in various diseases but its role i
Externí odkaz:
https://doaj.org/article/e33cb0622d164d038d065d98b67dae99
Autor:
Lauren P. Liu, Mohammed F. Gholam, Ahmed Samir Elshikha, Tamim Kawakibi, Nasseem Elmoujahid, Hassan H. Moussa, Sihong Song, Abdel A. Alli
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Human alpha-1 antitrypsin (hAAT) is a versatile protease inhibitor, but little is known about its targets in the aldosterone-sensitive distal nephron and its role in electrolyte balance and blood pressure control. We analyzed urinary electrolytes, os
Externí odkaz:
https://doaj.org/article/39214dccb6ec47b3a83591e25c088eb2
Autor:
Ling Yu, Mohammad-Zaman Nouri, Lauren P. Liu, Niharika Bala, Nancy D. Denslow, John F. LaDisa, Abdel A. Alli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13959 (2022)
The C-type natriuretic peptide receptor (NPRC) is expressed in many cell types and binds all natriuretic peptides with high affinity. Ligand binding results in the activation or inhibition of various intracellular signaling pathways. Although NPRC li
Externí odkaz:
https://doaj.org/article/0e1f7b916bf944f086ef64ade1fd3da9
Autor:
Kevin M. Chacko, Mohammad-Zaman Nouri, Whitney C. Schramm, Zeeshan Malik, Lauren P. Liu, Nancy D. Denslow, Abdel A. Alli
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1804 (2021)
Salt-sensitive hypertension resulting from an increase in blood pressure after high dietary salt intake is associated with an increase in the production of reactive oxygen species (ROS). ROS are known to increase the activity of the epithelial sodium
Externí odkaz:
https://doaj.org/article/2d0234273fba485c94928cac3f54d512
Publikováno v:
Endocrinology. 164
Pheochromocytomas (PCC) and paragangliomas (PGL) are rare neuroendocrine tumors with limited curative treatment options outside of surgical resection. Patients with mutations in succinate dehydrogenase subunit B (SDHB) are at an increased risk of mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf8ca79e12771d7fa09a6bf184cdbd6
https://doi.org/10.1210/endocr/bqad026
https://doi.org/10.1210/endocr/bqad026
Autor:
Nancy D. Denslow, Ling Yu, Lauren P. Liu, John F. LaDisa, Kevin M. Chacko, Abdel A. Alli, Mohammad-Zaman Nouri
Publikováno v:
Am J Physiol Cell Physiol
Extracellular vesicles (EVs) contain biological molecules and are secreted by cells into the extracellular milieu. The endothelial sodium channel (EnNaC) plays an important role in modulating endothelial cell stiffness. We hypothesized EVs secreted f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab299461171d3d1d702bdd697b317068
https://doi.org/10.1152/ajpcell.00092.2020
https://doi.org/10.1152/ajpcell.00092.2020