Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lauren Narcross"'
Autor:
Michael E. Pyne, James A. Bagley, Lauren Narcross, Kaspar Kevvai, Kealan Exley, Meghan Davies, Qingzhao Wang, Malcolm Whiteway, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism’s prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is n
Externí odkaz:
https://doaj.org/article/5ee80e772d7d43c7bc892ed4826582d3
Autor:
Michael E. Pyne, Kaspar Kevvai, Parbir S. Grewal, Lauren Narcross, Brian Choi, Leanne Bourgeois, John E. Dueber, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Plants synthesize more than 3000 tetrahydroisoquinoline (THIQ) alkaloids, but only a few of them have been produced by engineered microbes and titers are very low. Here, the authors increase (S)-reticuline titer to 4.6 g/L and repurpose the yeast Ehr
Externí odkaz:
https://doaj.org/article/1711736c3c694987b81eeec5d825890d
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124459 (2015)
Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The feasibility of morphinan synthesis in recombinant Saccharomyces cerevisiae starting from the precursor (R,S)-norlaudanosoli
Externí odkaz:
https://doaj.org/article/e709d90b36094462b4cefd377e7a806f
Autor:
Lauren Narcross, Michael E. Pyne, Kaspar Kevvai, Ka-Hei Siu, John E. Dueber, Vincent J. J. Martin
The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises over 2,500 members, including the pharmaceuticals morphine, codeine, and papaverine as well as the antibiotics sanguinarine and chelerythrine used in animal hus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f6998ca3d3e8ce612be2b7976df778
https://doi.org/10.1101/2023.05.19.541502
https://doi.org/10.1101/2023.05.19.541502
Autor:
Michael E. Pyne, James A. Bagley, Lauren Narcross, Kaspar Kevvai, Kealan Exley, Meghan Davies, Qingzhao Wang, Malcolm Whiteway, Vincent J.J. Martin
Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism’s prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is not suited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ed600ea452b89b7956abd36dd4cc9ad
https://doi.org/10.1101/2023.04.23.537879
https://doi.org/10.1101/2023.04.23.537879
Autor:
Kaspar Kevvai, Leanne Bourgeois, Brian Choi, John E. Dueber, Parbir Grewal, Vincent J. J. Martin, Lauren Narcross, Michael E. Pyne
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While microbial specie
Autor:
Parbir Grewal, Lauren Narcross, Martin Vjj, Michael E. Pyne, Leanne Bourgeois, Kaspar Kevvai, Bernard Choi, John E. Dueber
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogues. The plant kingdom manufactures more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189504dd9f1c0c828883575d63f859fa
Publikováno v:
Plant physiology. 179(3)
An overview of common challenges and strategies underlying efforts to reconstruct plant isoprenoid, alkaloid, phenylpropanoid, and polyketide biosynthetic pathways in microbial systems.
Publikováno v:
ACS Synthetic Biology. 5:1505-1518
The ever-increasing quantity of data deposited to GenBank is a valuable resource for mining new enzyme activities. Falling costs of DNA synthesis enables metabolic engineers to take advantage of this resource for identifying superior or novel enzymes
Autor:
Alex Campbell, Elena Fossati, Meghan E Davies, Leanne Bourgeois, Lauren Narcross, Vincent J. J. Martin, Cecilie Cetti Hansen, Michael E. Pyne
Publikováno v:
Biotechnology of Natural Products ISBN: 9783319679020
Of the roughly 12,000 alkaloids naturally produced by plant species, roughly half comprise the monoterpene indole alkaloid (MIA) and benzylisoquinoline alkaloid (BIA) families. These compounds include the opiate analgesics morphine and codeine, the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf5dd1dae6303fe7a05fc560d9fe0de
https://doi.org/10.1007/978-3-319-67903-7_5
https://doi.org/10.1007/978-3-319-67903-7_5