Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lauren Mullin"'
Publikováno v:
Metabolites, Vol 11, Iss 6, p 379 (2021)
The effects of intravenous gefitinib (10 mg/kg), an anilinoquinazoline thymidylate kinase inhibitor (TKI), selective for the epidermal growth factor receptor (EGFR), on the urinary metabotypes of mice were studied. We hypothesized that, in response t
Externí odkaz:
https://doaj.org/article/d8e3ccbde82d433bb49f6515eaf72751
Autor:
Robert A. Dilorenzo, Lauren Mullin, Ingrid Ericson Jogsten, Karl J. Jobst, Leo W. Y. Yeung, Robert S. Plumb, Eric J. Reiner
Publikováno v:
Analytica Chimica Acta. 1125:29-40
Dust analysis provides a means to assess the degree of exposure of humans in an indoor environment to various contaminant classes such as flame retardants, pesticides and others. There is increasing interest in non-targeted acquisitions using high re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83ba43764e65050f243393071db1e8c
https://doi.org/10.1016/j.aca.2020.05.052
https://doi.org/10.1016/j.aca.2020.05.052
Publikováno v:
Metabolites, Vol 11, Iss 379, p 379 (2021)
Metabolites
Volume 11
Issue 6
Metabolites
Volume 11
Issue 6
The effects of intravenous gefitinib (10 mg/kg), an anilinoquinazoline thymidylate kinase inhibitor (TKI), selective for the epidermal growth factor receptor (EGFR), on the urinary metabotypes of mice were studied. We hypothesized that, in response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a60c41afa719ebf943f34f24dc46c1
https://www.mdpi.com/2218-1989/11/6/379
https://www.mdpi.com/2218-1989/11/6/379
Autor:
Johannes P. C. Vissers, Ian D. Wilson, David Higton, Lauren Mullin, Robert S. Plumb, Martin Palmer
1-β-O-Acyl-glucuronides (AGs) are common metabolites of carboxylic acid-containing xenobiotics, including, e.g., many nonsteroidal anti-inflammatory drugs (NSAIDs). They are of concern to regulatory authorities because of the association of these me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2868360f3169d35eb0cd68d2425e90d9
http://hdl.handle.net/10044/1/99183
http://hdl.handle.net/10044/1/99183
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1179
The accurate determination of the pharmacokinetics (PK) of a candidate drug molecule is critical in both drug discovery and development. Over the last 30 years, the sensitivity and selectivity of LC/MS has resulted in it being established as the tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d029e46d158cbf6fc922626cc31b27
https://pubmed.ncbi.nlm.nih.gov/34218093
https://pubmed.ncbi.nlm.nih.gov/34218093
Autor:
Adam King, Lee A. Gethings, Ian D. Wilson, Robert S. Plumb, Lauren Mullin, Robert J. Riley, Billy J. Molloy
The metabolism and pharmacokinetics of gefitinib (Iressa®, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholino-propoxy)quinazolin-4-amine), a selective thymidylate kinase inhibitor for the epidermal growth factor receptor (EGFR), was studied after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae9f389da99895e4846cda72766c338
Autor:
Lauren Mullin, Adam Ladak, Myrna J. Simpson, Sophia A. Schreckenbach, Derek C. G. Muir, Karl J. Jobst, Denina B.D. Simmons
Publikováno v:
Analytical chemistry. 93(3)
The identity of an unknown environmental pollutant is reflected by the mass and dissociation chemistry of its (quasi)molecular ion. Gas chromatography-atmospheric pressure chemical ionization-mass spectrometry (GC-APCI-MS) increases the yield of mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6299cabb155245c99f212a9f45c558
https://pubmed.ncbi.nlm.nih.gov/33355455
https://pubmed.ncbi.nlm.nih.gov/33355455
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S73-S74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c151b4ad75dce16172c5c4a5106707
https://doi.org/10.1016/j.dmpk.2020.04.168
https://doi.org/10.1016/j.dmpk.2020.04.168
Autor:
Lee A. Gethings, Lauren Mullin, Paul D. Rainville, Robert D. Trengove, Robert S. Plumb, Adam King, Ian D. Wilson, Giorgis Isaac
The incorporation of ion mobility (IM) into LC-MS analysis has been demonstrated to result in the generation of superior quality MS and MS/MS spectral data as well as providing enhanced resolution in the IM dimension based on lipid class. Here a sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc67b35e25caffee713bcae2c5ae3fa1
http://hdl.handle.net/10044/1/77671
http://hdl.handle.net/10044/1/77671
Autor:
Robert S. Plumb, David R. Katz, Nicole Riddell, Lauren Mullin, Ingrid Ericson Jogsten, Leo W. Y. Yeung, Jennifer A. Burgess
Emerging per- and polyfluorinated compounds (PFAS) compounds are of increasing interest for environmental monitoring, one being hexafluoropropylene oxide-dimer acid (HFPO-DA), commonly referred to as GenX. The following review describes existing liqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d129b7c7dd6c5a15508391a3de64db
https://europepmc.org/articles/PMC6733277/
https://europepmc.org/articles/PMC6733277/