Výsledky vyhledávání - "Lauren Matlack"

Abstract P1-21-07: Implications for chronoradiobiology: Differential effect of radiation response for breast cancer patients with brain metastases depending on treatment time

Autor: Lauren Matlack, Joseph Lombardo, Nicolas Nelson, Alexandria Smith, Wenyin Shi, Nicole Simone

Publikováno v: Cancer Research. 82:P1-21

Purpose/Objectives: Circadian clock dysregulation has been implicated in cancer risk such that The World Health Organization classifies circadian disruption as a probable carcinogen following several reports of night shift workers with an increased r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95a5d5678602bb9bc94a53b41de21749
https://doi.org/10.1158/1538-7445.sabcs21-p1-21-07

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Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial

Publikováno v: Nature Cancer. 2:1124-1135

Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable (MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains challenging. We conducted a single-arm, non-randomized, phase II trial (NCT03104

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::991579e2e4f5b9b9fc7265f801fe62e1
https://doi.org/10.1038/s43018-021-00269-7

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Radiation Induced Checkpoint Immunotherapy Response in Refractory Colorectal and Pancreatic Adenocarcinoma

Immune checkpoint blockade has limited efficacy in microsatellite stable (MSS) colorectal (CRC) and pancreatic (PDAC) cancer. Preclinical models have demonstrated the use of radiation to activate the innate immune response and stimulate responsivenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e56b0a1948d63053def5275a1df4e7f
https://doi.org/10.21203/rs.3.rs-58489/v1

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Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology

Autor: Nicolas Nelson, Joseph Lombardo, Lauren Matlack, Alexandria Smith, Kamryn Hines, Wenyin Shi, Nicole L. Simone

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1331, p 1331 (2022)

Circadian disruption has been linked to cancer development, progression, and radiation response. Clinical evidence to date shows that circadian genetic variation and time of treatment affect radiation response and toxicity for women with breast cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f719e0f4d1bee5c128306cf86d97ac95
https://doi.org/10.3390/ijms23031331

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Evaluating the Impact of Combination of Nivolumab and Ipilimumab to Liver/Lung SBRT on Local Control for Colorectal and Pancreatic Cancer: A Pooled Analysis of Two Prospective Trials

Autor: Lorraine C. Drapek, Lauren Matlack, A.S. Parikh, J.Y. Wo, Christine E. Eyler, H.J. Roberts, Bronwen Foreman, Andrew X. Zhu, Theodore S. Hong, E. Van Seventer, David P. Ryan, Leilana Ly, Beow Y. Yeap

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 105:S112

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddd609522fb3215cf2d2a5068720242e
https://doi.org/10.1016/j.ijrobp.2019.06.608

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Proof of concept of the abscopal effect in MSS GI cancers: A phase 2 study of ipilimumab and nivolumab with radiation in metastatic pancreatic and colorectal adenocarcinoma

Autor: Colin D. Weekes, Jill N. Allen, David T. Ting, Jennifer Y. Wo, Lauren Matlack, Bronwen Foreman, Theodore S. Hong, Bruce J. Giantonio, Leilana Ly, David P. Ryan, Andrew X. Zhu, Jeffrey W. Clark, Aparna Raj Parikh, Ryan B. Corcoran, E. Van Seventer, Lorraine N. Drapek, Lawrence S. Blaszkowsky, Beow Y. Yeap

Publikováno v: Annals of Oncology. 30:iv128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50550ecce6346c46ec5009050d6c509b
https://doi.org/10.1093/annonc/mdz154.007

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A phase II study of ipilimumab and nivolumab with radiation in microsatellite stable (MSS) metastatic colorectal adenocarcinoma (mCRC)

Autor: Bronwen Foreman, Colin D. Weekes, Jennifer Y. Wo, Lawrence S. Blaszkowsky, David T. Ting, Leilana Ly, Theodore S. Hong, Aparna Raj Parikh, Emily E. Van Seventer, Lauren Matlack, Jill N. Allen, Bruce J. Giantonio, David P. Ryan, Beow Y. Yeap, Lorraine C. Drapek, Jeffrey W. Clark, Ryan B. Corcoran, Andrew X. Zhu

Publikováno v: Journal of Clinical Oncology. 37:3514-3514

3514 Background: mCRC remains a lethal cancer and immunotherapy in MSS mCRC has yet to show significant activity. In preclinical models, radiation induced cellular damage may increase responsiveness to immunotherapy via the abscopal effect, with evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a41806d2ef6a58298a596519583f1e
https://doi.org/10.1200/jco.2019.37.15_suppl.3514

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