Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lauren M. Zasadil"'
Autor:
Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Mark E. Burkard, Beth A. Weaver, Christopher Flynn, P. Todd Stukenberg
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage repair during S-phase.
Externí odkaz:
https://doaj.org/article/aeb3375ffa3047b2a1cbf2d36199aaec
Autor:
Mark E. Burkard, Beth A. Weaver, Sandeep Saha, Kari B. Wisinski, Josephine M. Harter, Jennifer J. Laffin, Craig Kanugh, Hyunjung Kim, Ryan A. Denu, Amber Lasek, Lauren M. Zasadil, Robert F. Lera, Brittany Zachek, Alka Choudhary
This file contains Supplementary Table 1 and provides hazard ratios for recurrence free survival and overall survival for polyploidy and clinical variables using a Cox proportional hazard model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12e9b0c0f29f0af487036bc12d17472
https://doi.org/10.1158/1535-7163.22503648
https://doi.org/10.1158/1535-7163.22503648
Autor:
Mark E. Burkard, Beth A. Weaver, Sandeep Saha, Kari B. Wisinski, Josephine M. Harter, Jennifer J. Laffin, Craig Kanugh, Hyunjung Kim, Ryan A. Denu, Amber Lasek, Lauren M. Zasadil, Robert F. Lera, Brittany Zachek, Alka Choudhary
This file contains supplementary figures S1-S4. These illustrate correlation of ploidy from chromosome 17 FSIH versus 6-chromosome FISH, chromosome spreads of cell lines, additional dose-response curves, and data demonstrating DPBQ does not operate b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776bcb0317a3033234b9b87e5ffafbed
https://doi.org/10.1158/1535-7163.22503651.v1
https://doi.org/10.1158/1535-7163.22503651.v1
Autor:
Mark E. Burkard, Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Christopher Flynn, P. Todd Stukenberg, Beth A. Weaver
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Cancer
BMC Cancer
Background Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage repair during S-phase. We and o
Autor:
Amber Lasek, Jun Wan, Kayla Correia-Staudt, Tim S. Bugni, Kari B. Wisinski, Amber S. Zhou, Stephanie M. McGregor, Amy M. Fowler, Mark E. Burkard, Jonathan Fitzgerald, John B. Tucker, Karla Esbona, Lauren M. Zasadil, Christina M. Scribano, Amye J. Tevaarwerk, Ryan Molini, Beth A. Weaver, Ruth O'Regan, Angela M. Lager, Jennifer Laffin, Rick Chappell
Publikováno v:
Sci Transl Med
Paclitaxel (Taxol) is a cornerstone of cancer treatment. However, its mechanism of cytotoxicity is incompletely understood and not all patients benefit from treatment. We show that patients with breast cancer did not accumulate sufficient intratumora
Autor:
Charanjeet Kaur, David J. Beebe, Lauren M. Zasadil, Sean D. Ryan, David J. Guckenberger, Beth A. Weaver, Eric M. C. Britigan, Amy R. Moser
Publikováno v:
Molecular Biology of the Cell
Expression of a truncated allele of the Apc tumor suppressor causes intestinal tumors with a low rate of chromosomal instability (CIN). Increasing the rate of CIN suppresses tumor growth without inhibiting tumor initiation in both the small intestine
Publikováno v:
Cancer Research. 76:P3-07
Background: Paclitaxel is one of the most effective therapies for breast cancer, although many patients do not benefit. Our goal is to identify those who will benefit, by understanding how this drug contributes to chromosomal instability (CIN). CIN i
Publikováno v:
Molecular Biology of the Cell
The ARF tumor suppressor is best known for its role in stabilizing p53. This study identifies p53-independent functions of ARF in chromosome segregation and the mitotic checkpoint. Mitotic defects caused by loss of ARF are recapitulated by Aurora B o
Publikováno v:
Developmental cell. 39(6)
Errors in chromosome segregation during mitosis have been recognized as a hallmark of tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic abnormalities drive tumorigenesis. Recent work has shown that mitotic defec
Publikováno v:
Seminars in Cell & Developmental Biology. 24:370-379
Mitotic defects leading to aneuploidy have been recognized as a hallmark of tumor cells for over 100 years. Current data indicate that ~85% of human cancers have missegregated chromosomes to become aneuploid. Some maintain a stable, aneuploid karyoty