Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lauren M. Thorpe"'
Autor:
Carolynn E. Ohlson, Jennifer M. Spangle, Lauren M. Thorpe, Lewis C. Cantley, Thomas M. Roberts, Hailing Cheng, Jean J. Zhao
Publikováno v:
Proceedings of the National Academy of Sciences. 114:7095-7100
Mutation or loss of the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is emerging as a transforming factor in cancer, but the mechanism of transformation has been controversial. Here we find that hemizygous deletion of the PIK3R1 gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c046933aca24215fa8fe81f9cdcb2fc8
https://doi.org/10.1073/pnas.1704706114
https://doi.org/10.1073/pnas.1704706114
Autor:
Sarah R. Walker, David A. Frank, Thomas M. Roberts, Jean J. Zhao, Haluk Yuzugullu, Thanh Von, Lauren M. Thorpe
Publikováno v:
Cell Discovery
Loss of PTEN, a negative regulator of the phosphoinositide 3-kinase signaling pathway, is a frequent event in T-cell acute lymphoblastic leukemia, suggesting the importance of phosphoinositide 3-kinase activity in this disease. Indeed, hyperactivatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6a70ac459110db908bf1738b4fb305
https://doi.org/10.1038/celldisc.2016.30
https://doi.org/10.1038/celldisc.2016.30
Autor:
James A. Knost, Vincent A. Miller, Srinivas Jujjavarapu, Nguyet Le‐Lindqwister, Alexa B. Schrock, Lauren M. Thorpe, Siraj M. Ali, Rachel L. Erlich, Jane Liu
Publikováno v:
Headneck. 39(3)
Background Salivary ductal carcinoma and carcinoma ex pleomorphic adenoma (CEPA) are aggressive salivary gland cancers with poor prognosis. The standard of care is resection with or without radiotherapy, and there are no established systemic therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af602b3cc6bc5e74229ea6a06692d183
https://pubmed.ncbi.nlm.nih.gov/28006087
https://pubmed.ncbi.nlm.nih.gov/28006087
Autor:
Sandra G Zimmerman, Brooke M. McCartney, Lauren M. Thorpe, Carolyn A. Mallozzi, Vilma R. Medrano
Publikováno v:
Developmental Biology. 340(1):54-66
The tumor suppressor Adenomatous polyposis coli (APC) is a negative regulator of Wnt signaling and functions in cytoskeletal organization. Disruption of human APC in colonic epithelia initiates benign polyps that progress to carcinoma following addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c0be953dd7ab4b0380b63dc3b9b805