Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Lauren M. Pachman"'
Autor:
Jacob C. Spitznagle, Akadia Kacha-Ochana, Joan M. Cook-Mills, Gabrielle A. Morgan, Lauren M. Pachman
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-6 (2024)
Abstract Background Juvenile dermatomyositis (JDM) is a systemic vasculopathy associated with metabolic derangements and possible increased risk for premature atherosclerosis. Oxidation of low-density lipoprotein (LDL) in the endothelium is an early
Externí odkaz:
https://doaj.org/article/986ecb24e1a24bf6b775cd8a8f13fe5b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Humoral primary immunodeficiencies are the most prevalent form of primary immunodeficiency (PID). Currently, there is no convenient method to quantify newly formed B cells. The aim of this proof-of-concept study was to quantitate the ratio o
Externí odkaz:
https://doaj.org/article/90b350488c8b4fe68f2f7ec57f116a18
Autor:
Amer Khojah, Madeline Schutt, Gabrielle Morgan, Ameera Bukhari, Nicolas Bensen, Aaruni Khanolkar, Lauren M. Pachman
Publikováno v:
Clinical Immunology Communications, Vol 5, Iss , Pp 20-25 (2024)
This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %)
Externí odkaz:
https://doaj.org/article/93727d4a8ec144cb81ec35aa79945c61
Publikováno v:
Clinical Immunology Communications, Vol 3, Iss , Pp 42-45 (2023)
RNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from av
Externí odkaz:
https://doaj.org/article/41bcdaad9ab5455e9d358d7b09c835e4
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-8 (2023)
Abstract Background Juvenile Dermatomyositis (JDM) is a rare autoimmune disease characterized by skin and muscle inflammation. The loss of nail fold capillary end row loops (ERL) is evidence of small vessel involvement in JDM. This study aimed to exa
Externí odkaz:
https://doaj.org/article/c7acdad65fcb49b994bbb98c1899a0b7
Publikováno v:
Clinical Immunology Communications, Vol 3, Iss , Pp 74-76 (2023)
Juvenile dermatomyositis (JDM) is a rare autoimmune disease characterized by chronic inflammation of the skin and muscle vasculature. Loss of nailfold capillary end row loops (ERL) is associated with disease activity. We now present the first report
Externí odkaz:
https://doaj.org/article/801be64a18d74bf59144be5ae718db2d
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract Background We lack a reliable indicator of disease activity in Juvenile Dermatomyositis (JDM), a rare disease. The goal of this study is to identify the association of nailfold capillary End Row Loop (ERL) loss with disease damage in childre
Externí odkaz:
https://doaj.org/article/4b585883cc3243d48e7bdefe626cf7bf
Autor:
Amer Khojah, Lauren M. Pachman, Ameera Bukhari, Chi Trinh, Gabrielle Morgan, Surya Pandey, I. Caroline Le Poole, Marisa S. Klein-Gitelman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7126 (2024)
Juvenile Dermatomyositis (JDM) is the most common inflammatory myopathy in pediatrics. This study evaluates the role of Natural Killer (NK) cells in Juvenile Dermatomyositis (JDM) pathophysiology. The study included 133 untreated JDM children with an
Externí odkaz:
https://doaj.org/article/def0db7fa6364fde97d305ad9f9bd3d4
Autor:
Elisa Ochfeld, Victoria Hans, Wil Marin, Najah Ahsan, Gabrielle Morgan, Lauren M. Pachman, Amer Khojah
Publikováno v:
BMC Rheumatology, Vol 6, Iss 1, Pp 1-7 (2022)
Abstract Background This pilot study’s primary aim was to determine if oligoclonal B cell expansion in children with Juvenile Dermatomyositis (JDM) predicts response to Rituximab therapy. We evaluated: (1) tissue B cell depletion efficacy by measur
Externí odkaz:
https://doaj.org/article/edb292df4a4c464f8e6ee1e9ddcb5fee
Autor:
Christopher Costin, Amer Khojah, Elisa Ochfeld, Gabrielle Morgan, Saravanan Subramanian, Marisa Klein-Gitelman, Xiao-Di Tan, Lauren M. Pachman
Publikováno v:
Diagnostics, Vol 13, Iss 16, p 2626 (2023)
In this study, we determined if B lymphocytosis may serve as a JDM biomarker for disease activity. Children with untreated JDM were divided into two groups based on age-adjusted B cell percentage (determined through flow cytometry): 90 JDM in the nor
Externí odkaz:
https://doaj.org/article/05f7d852d0f147e1974bf71a08c40f5c