Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lauren M. Gittings"'
Autor:
R. Keating Godfrey, Eric Alsop, Reed T. Bjork, Brijesh S. Chauhan, Hillary C. Ruvalcaba, Jerry Antone, Lauren M. Gittings, Allison F. Michael, Christi Williams, Grace Hala’ufia, Alexander D. Blythe, Megan Hall, Rita Sattler, Kendall Van Keuren-Jensen, Daniela C. Zarnescu
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-25 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comprise a spectrum of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is characterized by loss of nuclear TDP-43 and accumulation
Externí odkaz:
https://doaj.org/article/91372f6d7375474b8007a42f300fb060
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS
Externí odkaz:
https://doaj.org/article/c5861f14d9984d6d91846ead3941a04a
Autor:
Lauren M. Gittings, Sandrine C. Foti, Bridget C. Benson, Priya Gami-Patel, Adrian M. Isaacs, Tammaryn Lashley
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Frontotemporal lobar degeneration (FTLD) is pathologically subdivided based on the presence of particular pathological proteins that are identified in inclusion bodies observed post-mortem. The FTLD-FUS subgroup is defined by the presence of
Externí odkaz:
https://doaj.org/article/323b0f9391b8421680ee27591fdb42a1
Publikováno v:
Acta Neuropathologica
Dysregulated RNA metabolism is emerging as a crucially important mechanism underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically, genetically and pathologically overlapping disorder of amyotrophic lateral sclerosis (ALS).
Autor:
Priya Gami-Patel, Bridget C. Benson, Tammaryn Lashley, Sandrine C. Foti, Adrian M. Isaacs, Lauren M. Gittings
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Frontotemporal lobar degeneration (FTLD) is pathologically subdivided based on the presence of particular pathological proteins that are identified in inclusion bodies observed post-mortem. The FTLD-FUS subgroup is defined by the presence of the fuse
Autor:
Katherine M. Wilson, Teresa Niccoli, Linda Partridge, Pietro Fratta, Mercedes Pardo, Benedikt V. Holbling, Nicol Birsa, Lauren M. Gittings, Julia Bussmann, Annora Thoeng, Thomas G. Moens, Miranda C. Dyson, Adrian M. Isaacs, Magda L. Atilano, Jyoti S. Choudhary, Jacob Neeves, Lu Yu, Idoia Glaria, Erik Storkebaum
Publikováno v:
Acta Neuropathologica
Acta Neuropathol
Acta Neuropathologica, 137, 487-500
Acta Neuropathologica, 137, 3, pp. 487-500
Acta Neuropathol
Acta Neuropathologica, 137, 487-500
Acta Neuropathologica, 137, 3, pp. 487-500
A GGGGCC hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense repeat-containing transcripts undergo repeat-associated non-AUG-i
Autor:
Nathaniel S. Woodling, Jennifer Adcott, Janet M. Thornton, Linda Partridge, Benjamin Aleyakpo, Arjunan Rajasingam, Lauren M. Gittings, Ekin Bolukbasi, Dobril Ivanov, Teresa Niccoli, Andrea Foley
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Significance Aging is the main risk factor for the costliest diseases in today’s world. However, significant gaps remain in understanding how different cell types modulate this most common physiological process. Here, we use published single-cell g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c93bdec9f3299930a3a2647332f53e9
https://eprints.gla.ac.uk/278596/1/278596.pdf
https://eprints.gla.ac.uk/278596/1/278596.pdf
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M Gittings, Deepti Lall, Benjamin E Rabichow, Stephen Moore, Ryan Pevey, Lynette Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F Gendron, Robert H Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Background A mutation in the C9orf72 gene is the most common genetic mutation of familial and sporadic ALS, as well as familial FTD. While prior studies have focused on elucidating the mechanisms of neuronal dysfunction and neurodegeneration associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed9356d12a0c4f704bd87027f5bc041
https://doi.org/10.1101/2020.09.03.277459
https://doi.org/10.1101/2020.09.03.277459
Autor:
Tammaryn Lashley, David M. A. Mann, Daniel John Lightwood, Lauren M. Gittings, Lisa Nakayama, Sarfaraj Topia, Claire Troakes, Steven Boeynaems, Adrian M. Isaacs, Alison Clargo, Aaron D. Gitler
Publikováno v:
Acta Neuropathologica
Autor:
Dorothee Dormann, Stefan Reber, Luc Dupuis, Helena Ederle, Marian Hruska-Plochan, Eva-Maria Hock, Marc-David Ruepp, Florent Laferrière, Zuzanna Maniecka, Lucas Pelkmans, M K Sonu Sahadevan, Tammaryn Lashley, Lauren M. Gittings, Magdalini Polymenidou
Publikováno v:
Cell Reports
Cell Reports, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Cell Reports, Elsevier Inc, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Hock, E-M, Maniecka, Z, Hruska-Plochan, M, Reber, S, Laferrière, F, Sahadevan M K, S, Ederle, H, Gittings, L, Pelkmans, L, Dupuis, L, Lashley, T, Ruepp, M-D, Dormann, D & Polymenidou, M 2018, ' Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function ', Cell Reports, vol. 24, no. 4, pp. 987-1000.e7 . https://doi.org/10.1016/j.celrep.2018.06.094
Cell Reports, 24 (4)
Cell Reports, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Cell Reports, Elsevier Inc, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Hock, E-M, Maniecka, Z, Hruska-Plochan, M, Reber, S, Laferrière, F, Sahadevan M K, S, Ederle, H, Gittings, L, Pelkmans, L, Dupuis, L, Lashley, T, Ruepp, M-D, Dormann, D & Polymenidou, M 2018, ' Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function ', Cell Reports, vol. 24, no. 4, pp. 987-1000.e7 . https://doi.org/10.1016/j.celrep.2018.06.094
Cell Reports, 24 (4)
The primarily nuclear RNA-binding protein FUS (fused in sarcoma) forms pathological cytoplasmic inclusions in a subset of early-onset amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients. In response to cellular stress, FUS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26cd76ee2b60a0880af6400794f15f6
https://doi.org/10.1016/j.celrep.2018.06.094
https://doi.org/10.1016/j.celrep.2018.06.094