Výsledky vyhledávání - "Lauren M. Federici"

Akademický článek

Evaluation of Low versus High Volume per Minute Displacement CO2 Methods of Euthanasia in the Induction and Duration of Panic-Associated Behavior and Physiology

Autor: Debra L. Hickman, Stephanie D. Fitz, Cristian S. Bernabe, Izabela F. Caliman, Melissa M. Haulcomb, Lauren M. Federici, Anantha Shekhar, Philip L. Johnson

Publikováno v: Animals, Vol 6, Iss 8, p 45 (2016)

Current recommendations for the use of CO 2 as a euthanasia agent for rats require the use of gradual fill protocols (such as 10% to 30% volume displacement per minute) in order to render the animal insensible prior to exposure to levels of CO 2 that

Externí odkaz: https://doaj.org/article/57c3932dca124d4b8418124769086fde

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Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels

Autor: Philip L. Johnson, Lauren M. Federici, Andrei I. Molosh, David L. Haggerty, Eugene Nalivaiko, Anantha Shekhar, William A. Truitt, Stephanie D. Fitz, Cristian Bernabe

Publikováno v: Translational Psychiatry
Translational Psychiatry, Vol 9, Iss 1, Pp 1-14 (2019)

Genetic variation in serotonin transporter (SERT) that reduces transcriptional efficiency is associated with higher anxiety and fear traits and a greater incidence of post traumatic stress disorder (PTSD). Although previous studies have shown that ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555499b6e90717978d8fe53059ad3a17
https://doi.org/10.1038/s41398-019-0368-y

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Hypothalamic orexin’s role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model

Autor: Philip L. Johnson, Andrei I. Molosh, Lauren M. Federici, Stephanie D. Fitz, Pascal Bonaventure, William A. Truitt, Izabela F Caliman, Anantha Shekhar, Janet S. Carpenter

Publikováno v: Psychoneuroendocrinology. 65:127-137

Distressing symptoms such as hot flashes and sleep disturbances affect over 70% of women approaching menopause for an average of 4-7 years, and recent large cohort studies have shown that anxiety and stress are strongly associated with more severe an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13490a2af0ffa23379da69e2e76eeb9
https://doi.org/10.1016/j.psyneuen.2015.12.011

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Select panicogenic drugs and stimuli induce consistent increases in tail skin flushes and decreases in core body temperature

Autor: Stephanie D. Fitz, Anantha Shekhar, Izabela Facco Caliman, Philip L. Johnson, Lauren M. Federici

Publikováno v: Behavioural pharmacology. 30(4)

Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. rats) has largely been assayed through flight and avoidance behav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b869eac23394f9c0001c26540b79ae2b
https://pubmed.ncbi.nlm.nih.gov/30480550

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Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning

Autor: Dave Arendt, Lauren M. Federici, Philip L. Johnson, Andrei I. Molosh, Gerald A. Deehan, Cristian Bernabe, Zachary A. Rodd, Eric A. Engleman, Christopher A. Lowry, Stephanie D. Fitz, Anantha Shekhar

Publikováno v: Pharmacology Biochemistry and Behavior. 138:174-179

The basolateral and lateral amygdala nuclei complex (BLC) is implicated in a number of emotional responses including conditioned fear and social anxiety. Based on previous studies demonstrating that enhanced serotonin release in the BLC leads to incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf9a52e81824557d024d9b23e5fbeb4
https://doi.org/10.1016/j.pbb.2015.09.021

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OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2-INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES

Autor: Christopher J. Winrow, Lauren M. Federici, Philip L. Johnson, John J. Renger, Stephanie D. Fitz, Pascal Bonaventure, Shireman Brock T, Anantha Shekhar

Publikováno v: Depression and Anxiety. 32:671-683

Background The neuropeptides orexin A and B play a role in reward and feeding and are critical for arousal. However, it was not initially appreciated that most prepro-orexin synthesizing neurons are almost exclusively concentrated in the perifornical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fa770d33556e0205a5450841c403601
https://doi.org/10.1002/da.22403

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Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Autor: Lang Li, D. Wade Clapp, Steven P. Janasik, Yehia Mechref, Andrei I. Molosh, Rajesh Khanna, Chirayu P. Goswami, John P. Spence, Philip L. Johnson, Zaneer M. Segu, Anantha Shekhar, Su Jung Park, Cristian Bernabe, David H. Arendt, Lauren M. Federici, Weiguo Zhu

Publikováno v: Nature neuroscience

Children with neurofibromatosis type 1 (NF1) are increasingly recognized as having a high prevalence of social difficulties and autism spectrum disorders (ASDs). We demonstrated a selective social learning deficit in mice with deletion of a single Nf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e346e89edbe6160327b1ed1405eb91eb
https://doi.org/10.1038/nn.3822

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Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network

Autor: Brian C Samuels, Lauren M. Federici, Philip L. Johnson, Maureen C. Early, William A. Truitt, Nathan M. Hammes, Stephanie D. Fitz, Anantha Shekhar, Christopher A. Lowry

Publikováno v: Physiology & Behavior. 107:733-742

Background Although the hypothalamic orexin system is known to regulate appetitive behaviors and promote wakefulness and arousal (Sakurai, 2007 [56] ), this system may also be important in adaptive and pathological anxiety/stress responses (Suzuki et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9e68767409142ac411772d12e49b8d
https://doi.org/10.1016/j.physbeh.2012.04.016

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Anxiogenic CO2 stimulus elicits exacerbated hot flash-like responses in a rat menopause model and hot flashes in postmenopausal women

Autor: Anantha Shekhar, Stephanie D. Fitz, Todd C. Skaar, Janet S. Carpenter, Sarah Dorsey Roth, Philip L. Johnson, Connie Krier, Lauren M. Federici

Publikováno v: Menopause (New York, N.Y.). 23(11)

OBJECTIVE As longitudinal studies determined that anxiety is a strong risk factor for hot flashes, we hypothesized that an anxiogenic stimulus that signals air hunger (hypercapnic, normoxic gas) would trigger an exacerbated hot flash-associated incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc80d96b3f053348e33489584783030
https://pubmed.ncbi.nlm.nih.gov/27465717

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