Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lauren M. F. Merlo"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are closely related tryptophan catabolizing enzymes that have immunomodulatory properties. Although initially studied as modifiers of T cell activity, emerging evidence suggests IDO1 and IDO2 also have impo
Externí odkaz:
https://doaj.org/article/fe398fc5e7c848228d7f48c10797979e
Autor:
Lauren M. F. Merlo, Kathleen Sprouffske, Taylor C. Howard, Kristin L. Gardiner, Aleah F. Caulin, Steven M. Blum, Perry Evans, Antonio Bedalov, Paul D. Sniegowski, Carlo C. Maley
Publikováno v:
Evolutionary Applications, Vol 13, Iss 7, Pp 1615-1625 (2020)
Abstract Beneficial mutations that arise in an evolving asexual population may compete or interact in ways that alter the overall rate of adaptation through mechanisms such as clonal or functional interference. The application of multiple selective p
Externí odkaz:
https://doaj.org/article/5abdfcd4e2454303a429f2bf856baecd
Autor:
Lauren M. F. Merlo, James B. DuHadaway, James D. Montgomery, Wei-Dan Peng, Peter J. Murray, George C. Prendergast, Andrew J. Caton, Alexander J. Muller, Laura Mandik-Nayak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are two closely related tryptophan catabolizing enzymes encoded by linked genes. The IDO pathway is also immunomodulatory, with IDO1 well-characterized as a mediator of tumor immune evasion. Due to its homo
Externí odkaz:
https://doaj.org/article/564df2743520466b8950a559dcc7cf6e
Autor:
Mads Hald Andersen, Souvik Dey, Erika Sutanto-Ward, Katharina L Kopp, James DuHadaway, Arpita Mondal, Dema Ghaban, Inés Lecoq, Mai-Britt Zocca, Lauren M F Merlo, Laura Mandik-Nayak, Ayako Wakatsuki Pedersen, Alexander J Muller
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpre
Externí odkaz:
https://doaj.org/article/85b92312e7ef499e81e377e49eedf1d5
Autor:
Lauren M. F. Merlo, Weidan Peng, James B. DuHadaway, James D. Montgomery, George C. Prendergast, Alexander J. Muller, Laura Mandik-Nayak
Publikováno v:
J Immunol
IDO2 is one of two closely related tryptophan catabolizing enzymes induced under inflammatory conditions. In contrast to the immunoregulatory role defined for IDO1 in cancer models, IDO2 has a proinflammatory function in models of autoimmunity and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d171b0437814c26ea7a1e050c9523b4b
https://doi.org/10.4049/jimmunol.2100705
https://doi.org/10.4049/jimmunol.2100705
Autor:
Souvik, Dey, Erika, Sutanto-Ward, Katharina L, Kopp, James, DuHadaway, Arpita, Mondal, Dema, Ghaban, Inés, Lecoq, Mai-Britt, Zocca, Lauren M F, Merlo, Laura, Mandik-Nayak, Mads Hald, Andersen, Ayako Wakatsuki, Pedersen, Alexander J, Muller
Publikováno v:
Journal for Immunotherapy of Cancer
Background The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9b602e1823a90d97acfe785b648e7fd
https://pubmed.ncbi.nlm.nih.gov/32690770
https://pubmed.ncbi.nlm.nih.gov/32690770
Publikováno v:
Advances in experimental medicine and biology. 676
Aneuploidy is a ubiquitous feature of cancer and pre-cancerous lesions, yet its significance is poorly characterized. In this chapter, we review the role oftetraploidy and aneuploidy in progression. We examine how aneuploidy may contribute to the evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24b2b25baa638b9b4963e77d6402ec3d
https://pubmed.ncbi.nlm.nih.gov/20687466
https://pubmed.ncbi.nlm.nih.gov/20687466