Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lauren M. Drouin"'
Autor:
Yinxing Chen, Shiliang Hu, William Lee, Noel Walsh, Kayla Iozza, Neil Huang, Gregory Preston, Lauren M. Drouin, Nannan Jia, June Deng, Matthias Hebben, Jing Liao
Publikováno v:
Microorganisms, Vol 12, Iss 2, p 310 (2024)
One of the primary challenges in working with adeno-associated virus (AAV) lies in the inherent instability of its inverted terminal repeats (ITRs), which play vital roles in AAV replication, encapsidation, and genome integration. ITRs contain a high
Externí odkaz:
https://doaj.org/article/55b423e76b5c4528bcaaa86d72561929
Autor:
Lauren M Drouin
Publikováno v:
Cell and Gene Therapy Insights. 7:1139-1145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be73a031c9767e45b50746a4ee5bb700
https://doi.org/10.18609/cgti.2021.151
https://doi.org/10.18609/cgti.2021.151
Autor:
Barry J. Byrne, Antonette Bennett, R. Jude Samulski, Robert McKenna, Claire Rosebrough, Paul R. Chipman, Mark Potter, Mavis Agbandje-McKenna, Mario Mietzsch, Duncan Sousa, Matthew J. Burg, Lauren M. Drouin
Publikováno v:
J Struct Biol
AAV2.5 represents the first structure-guided in-silico designed Adeno-associated virus (AAV) gene delivery vector. This engineered vector combined the receptor attachment properties of AAV serotype 2 (AAV2) with the muscle tropic properties of AAV1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86f36e3cb13edfe191dc0aa18c2e8df
https://pubmed.ncbi.nlm.nih.gov/29775653
https://pubmed.ncbi.nlm.nih.gov/29775653
Autor:
Jarrod S. Johnson, Mavis Agbandje-McKenna, Wuping Li, R. Jude Samulski, Xiao Ping-Jie, Wu Zhijian, Liqun Zhang, Lauren M. Drouin, Joshua C Grieger, Raymond J. Pickles
Publikováno v:
Molecular Therapy. 17(12):2067-2077
Recombinant adeno-associated virus (AAV) vectors expressing the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been used to deliver CFTR to the airway epithelium of cystic fibrosis (CF) patients. However, no significant CFTR fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0d1996f04b8a41d3b424532e75559b
Autor:
Weijun Chen, Giovanni Cardone, Bridget Lins, Antonette Bennett, Lauren M. Drouin, Robert McKenna, Mandy E. Janssen, Mavis Agbandje-McKenna, Paul R. Chipman, Nicholas Muzyczka, Timothy S. Baker
Publikováno v:
Microscopy and Microanalysis, vol 22, iss S3
Author(s): Drouin, Lauren M; Lins, Bridget; Janssen, Mandy; Bennett, Antonette; Chipman, Paul R; McKenna, Robert; Chen, Weijun; Muzyczka, Nicholas; Cardone, Giovanni; Baker, Timothy S; Agbandje-McKenna, Mavis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b668880e773272ff2796ea716eca5704
https://doi.org/10.1017/s1431927616006516
https://doi.org/10.1017/s1431927616006516
Adeno-associated viruses (AAVs) have become important therapeutic gene delivery vectors in recent years. However, there are challenges, including intractable tissues/cell types and pre-existing immune responses, which need to be overcome for full rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4468827d60e79be4a9a740aa4e82afb0
https://europepmc.org/articles/PMC3921901/
https://europepmc.org/articles/PMC3921901/
Autor:
Jiangang Jiang, Xiaoyun Hu, Lin Yang, Lauren M. Drouin, Chunping Qiao, Mavis Agbandje-McKenna, Dongqiuye Pu, Xiao Xiao, Da-Zhi Wang, Chunlian Chen, Juan Li
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(10)
To engineer gene vectors that target striated muscles after systemic delivery, we constructed a random library of adeno-associated virus (AAV) by shuffling the capsid genes of AAV serotypes 1 to 9, and screened for muscle-targeting capsids by direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd72e953b3f110724568e9f0ec8af29b
https://pubmed.ncbi.nlm.nih.gov/19234115
https://pubmed.ncbi.nlm.nih.gov/19234115