Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lauren M. Cagen"'
Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat
Autor:
Marshall B. Elam, Henry G. Wilcox, Lauren M. Cagen, Xiong Deng, Rajendra Raghow, Poonam Kumar, Murray Heimberg, James C. Russell
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 12, Pp 2039-2048 (2001)
The corpulent JCR:LA-cp rat (cp/cp) is a useful model for study of the metabolic consequences of obesity and hyperinsulinemia. To assess the effect of hyperinsulinemia on VLDL secretion in this model, we measured rates of secretion of VLDL in perfuse
Externí odkaz:
https://doaj.org/article/b965049c35d04370b533667cfb56f062
Autor:
Rajendra Raghow, Edwards A. Park, Henry G. Wilcox, Xiong Deng, Marshall B. Elam, Lauren M. Cagen
Publikováno v:
Biochemical and Biophysical Research Communications. 290:256-262
We have cloned 5 kb of genomic DNA encompassing 1.72 kb of 5′-regulatory sequence and exons 1-c and 2 of the rat SREBP-1c gene. A 1.5-kb segment upstream from the transcription start site was ligated ahead of the luciferase reporter gene and tested
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 2, Pp 311-318 (1994)
We reported previously that dietary cholesterol produces hypertriglyceridemia in the rat, accompanied by reduced oxidation and increased incorporation of exogenous fatty acid into hepatic triglyceride and increased secretion of very low density lipop
Publikováno v:
Journal of Lipid Research, Vol 34, Iss 6, Pp 933-941 (1993)
Experiments were conducted in the intact rat and in the isolated, perfused rat liver to investigate the possibility that the increase in the concentration of hepatic triglyceride and increase in the secretion of the very low density lipoprotein (VLDL
Publikováno v:
Journal of Lipid Research, Vol 33, Iss 2, Pp 179-191 (1992)
Male rats were fed a cholesterol-free diet or the same diet supplemented with either 0.05, 0.1, 0.25, 0.5, 1, or 2% C for 21 days to investigate the effects of cholesterol on secretion of very low density lipoprotein (VLDL). Cholesterol feeding incre
Publikováno v:
Biochemical and Biophysical Research Communications. 183:21-26
Livers isolated from adult male rats were perfused in vitro with oleic acid (0.6 mM) as a complex with bovine serum albumin. Albumin alone was infused in control experiments. Oleic acid exerted a biphasic effect on incorporation of 3H2O into choleste
Autor:
Henry G. Wilcox, Xiong Deng, Chandrahasa R. Yellaturu, Edwards A. Park, Rajendra Raghow, Marshall B. Elam, Lauren M. Cagen
Publikováno v:
The FASEB Journal. 23
Autor:
Chandrahasa R. Yellaturu, Edwards A. Park, Rajendra Raghow, Xiong Deng, C. M. Mansbach, Marshall B. Elam, Shadab A. Siddiqi, Henry G. Wilcox, Lauren M. Cagen
The regulation of lipid homeostasis by insulin is mediated in part by the enhanced transcription of the gene encoding SREBP-1c (sterol regulatory element-binding protein-1c). Nascent SREBP-1c is synthesized and embedded in the endoplasmic reticulum (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe0b92f1a8a3a773fed38618c1f94a3
https://europepmc.org/articles/PMC2658047/
https://europepmc.org/articles/PMC2658047/
Autor:
Linus A. Wodi, Robert J. Rooney, Marshall B. Elam, Micheal H. Bahr, George S M Cowan, Micheal C. Allan, Malay S. Gandhi, Rajendra Raghow, J. Christopher Corton, Henry G. Wilcox, George E. Howell, George A. Cook, Xiong Deng, Divyan Patel, Thomas A. Hughes, Chandrahasa R. Yellaturu, Edwards A. Park, Ivan C. Gerling, M. Lloyd Hiler, Lauren M. Cagen
Publikováno v:
Obesity (Silver Spring, Md.). 17(8)
The objective of this study was to determine the molecular bases of disordered hepatic function and disease susceptibility in obesity. We compared global gene expression in liver biopsies from morbidly obese (MO) women undergoing gastric bypass (GBP)
Autor:
Henry G. Wilcox, Chandrahasa R. Yellaturu, Marshall B. Elam, Lauren M. Cagen, Rajendra Raghow, Edwards A. Park, Xiong Deng
Publikováno v:
Biochemical and biophysical research communications. 332(1)
Insulin and cAMP have opposing effects on de novo fatty acid synthesis in liver and in cultured hepatocytes mediated by sterol-regulatory element binding protein (SREBP). To determine whether these agents regulate the cleavage of full-length SREBP to