Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lauren M. Angley"'
Autor:
David A. Dougan, Liz J. Valente, Hanmiao Zhan, Kornelius Zeth, Lauren M. Angley, Kaye N. Truscott, Erica J. Brodie, Matthew A. Perugini, Tamanna Saiyed, Philip R. Strack, Verena J. Schuenemann, Bradley R. Lowth
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Over a decade ago Polymerase δ interacting protein of 38 kDa (PDIP38) was proposed to play a role in DNA repair. Since this time, both the physiological function and subcellular location of PDIP38 has remained ambiguous and our present understanding
Autor:
Lauren M. Angley, Michael D. W. Griffin, Renwick C. J. Dobson, Andrew J. Watson, Rachel A. North, Antony J. Fairbanks, André O. Hudson, Sarah C. Atkinson, Benjamin R. Burgess, Hironori Suzuki, Sarah A. Kessans, Arvind Varsani
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 69:306-312
The enzyme N-acetylneuraminate lyase (EC 4.1.3.3) is involved in the metabolism of sialic acids. Specifically, the enzyme catalyzes the retro-aldol cleavage of N-acetylneuraminic acid to form N-acetyl-D-mannosamine and pyruvate. Sialic acids comprise
Publikováno v:
Biochimie. 92:116-120
Pyruvate kinase (PK) is the key control point of glycolysis—the biochemical pathway central to energy metabolism and the production of precursors used in biosynthesis. PK type 1 from Escherichia coli (Ec-PK1) is activated by both fructose-1,6-bisph
Autor:
Danny M. Hatters, Jinwei Tang, Andrew F. Hill, Maya A. Olshina, Michael F. Bailey, Yasmin M. Ramdzan, Lauren M. Angley
Publikováno v:
The Journal of biological chemistry. 285(28)
Huntington disease is caused by expanded polyglutamine sequences in huntingtin, which procures its aggregation into intracellular inclusion bodies (IBs). Aggregate intermediates, such as soluble oligomers, are predicted to be toxic to cells, yet beca
Publikováno v:
Analytical biochemistry. 390(2)
The fluorescence detection system for the analytical ultracentrifuge (AU-FDS) enables the measurement of hydrodynamic properties and interactions of biomolecules at subnanomolar concentrations. In this study, we describe methods for (i) preparing and