Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Lauren M Sparks"'
Autor:
Neil M Johannsen, Lauren M Sparks, Zhengyu Zhang, Conrad P Earnest, Steven R Smith, Timothy S Church, Eric Ravussin
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e62973 (2013)
To assess the determinants of exercise training-induced improvements in glucose control (HbA1C) including changes in serum total adiponectin and FFA concentrations, and skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PG
Externí odkaz:
https://doaj.org/article/1e890243778f47c1b53ff197d2e2076b
Autor:
Lauren M Sparks, Cedric Moro, Barbara Ukropcova, Sudip Bajpeyi, Anthony E Civitarese, Matthew W Hulver, G Hege Thoresen, Arild C Rustan, Steven R Smith
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21068 (2011)
Disturbances in lipid metabolism are strongly associated with insulin resistance and type 2 diabetes (T2D). We hypothesized that activation of cAMP/PKA and calcium signaling pathways in cultured human myotubes would provide further insight into regul
Externí odkaz:
https://doaj.org/article/8f0f40e44a654cafbb9a6a1e829c8fdb
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4889 (2024)
Type 2 diabetes (T2D) is characterized by muscle metabolic dysfunction that exercise can minimize, but some patients do not respond to an exercise intervention. Myokine secretion is intrinsically altered in patients with T2D, but the role of myokines
Externí odkaz:
https://doaj.org/article/a17f31f344c44002b336dddd450138b7
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/1e5ac5e013ec4b74bfcb3724735fb2ff
Autor:
Jake W. Willows, Gilian Gunsch, Emma Paradie, Magdalena Blaszkiewicz, Jeffrey R. Tonniges, Maria F. Pino, Steven R. Smith, Lauren M. Sparks, Kristy L. Townsend
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106189- (2023)
Summary: Peripheral neuropathy, which can include axonal degeneration and/or demyelination, impacts adipose tissues with obesity, diabetes, and aging. However, the presence of demyelinating neuropathy had not yet been explored in adipose. Both demyel
Externí odkaz:
https://doaj.org/article/0a17f561f6304c6aa76f43e79b802080
Autor:
Katie L. Whytock, Adeline Divoux, Yifei Sun, Meghan Hopf, Reichelle X. Yeo, Maria F. Pino, GongXin Yu, Steven R. Smith, Martin J. Walsh, Lauren M. Sparks
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102054- (2023)
Summary: Automated single-cell dispensing is incompatible with white adipose tissue (WAT) due to lipid-laden adipocytes. Single-nuclei RNA-Seq permits transcriptional profiling of all cells from WAT. Human WAT faces unique technical challenges in iso
Externí odkaz:
https://doaj.org/article/6f05c012201949db8ce2f85ec5f3f189
Autor:
Melissa L. Erickson, Jacob M. Allen, Daniel P. Beavers, Linda M. Collins, Karina W. Davidson, Kirk I. Erickson, Karyn A. Esser, Matthijs K. C. Hesselink, Kerrie L. Moreau, Eric B. Laber, Charlotte A. Peterson, Courtney M. Peterson, Jane E. Reusch, John P. Thyfault, Shawn D. Youngstedt, Juleen R. Zierath, Bret H. Goodpaster, Nathan K. LeBrasseur, Thomas W. Buford, Lauren M. Sparks
Publikováno v:
Geroscience, 45(1), 569-589. Springer International Publishing
Abstract Exercise is a cornerstone of preventive medicine and a promising strategy to intervene on the biology of aging. Variation in the response to exercise is a widely accepted concept that dates back to the 1980s with classic genetic studies iden
Publikováno v:
Nature Reviews Endocrinology. 19:285-298
Autor:
Mingqi Zhou, Cassandra Van, Jeffrey Molendijk, Ivan Yao-Yi Chang, Casey Johnson, Leandro M. Velez, Reichelle X. Yeo, Hosung Bae, Johnny Le, Natalie Larson, Ron Pulido, Carlos H V Nascimento-Filho, Andrea Hevener, Lauren M. Sparks, Jaime N. Justice, Erin E. Kershaw, Ivan Marazzi, Nicholas Pannunzio, Dequina Nicholas, Benjamin Parker, Cholsoon Jang, Selma Masri, Marcus Seldin
/IntroductionInter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes to many human diseases. Beginning with the discovery of insulin over a century ago, characterization of molecules respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c627cd847be25fc88c25f9732bceb22
https://doi.org/10.1101/2023.05.10.540142
https://doi.org/10.1101/2023.05.10.540142
Autor:
Aliza B. Rubenstein, J. Matthew Hinkley, Venugopalan D. Nair, German Nudelman, Robert A. Standley, Fanchao Yi, GongXin Yu, Todd A. Trappe, Marcas M. Bamman, Scott W. Trappe, Lauren M. Sparks, Bret H. Goodpaster, Rick B. Vega, Stuart C. Sealfon, Elena Zaslavsky, Paul M. Coen
Publikováno v:
Am J Physiol Endocrinol Metab
Age-related declines in cardiorespiratory fitness and physical function are mitigated by regular endurance exercise in older adults. This may be due, in part, to changes in the transcriptional program of skeletal muscle following repeated bouts of ex