Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Lauren M Schmitt"'
Autor:
Lauren E. Ethridge, Ernest V. Pedapati, Lauren M. Schmitt, Jordan E. Norris, Emma Auger, Lisa A. De Stefano, John A. Sweeney, Craig A. Erickson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Recent failures translating preclinical behavioral treatment effects to positive clinical trial results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological pathways and associated measures, such as electroencep
Externí odkaz:
https://doaj.org/article/f635ea17ba604bad9e5cf585cd8148c8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Fragile X Syndrome (FXS) is an X-linked disorder leading to the loss of expression of FMR1-protein product, FMRP. The absence or deficiency of FMRP is thought to result in the characteristic FXS phenotypes, including intellectual disability.
Externí odkaz:
https://doaj.org/article/6f530f071d794033827218f428cf2499
Autor:
Debra L. Reisinger, Matthew S. Goodwin, Paul S. Horn, Lauren M. Schmitt, Marika C. Coffman, Rebecca C. Shaffer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Autistic youth experience several behavioral and emotional characteristics that can predispose them to emotion dysregulation (ED). Current literature examining ED in autism spectrum disorder (ASD) is limited to parent- and self-reported meas
Externí odkaz:
https://doaj.org/article/2f8c31d6726d4b6785c5084789745e7c
Autor:
Marika Coffman, Miranda Wells, Lauren M. Schmitt, Debra L. Reisinger, Paul S. Horn, Rebecca C. Shaffer
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionAutistic children and adolescents frequently experience emotion dysregulation, or difficulties with appropriately modifying their emotional reactions. Caregivers of autistic teens frequently seek psychotherapy support for navigating chall
Externí odkaz:
https://doaj.org/article/6b97152680d74b259efdd6e1bcb4a09a
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2015)
The cerebellum has been repeatedly implicated in gene expression, rodent model and post-mortem studies of autism spectrum disorder (ASD). How cellular and molecular anomalies of the cerebellum relate to clinical manifestations of ASD remains unclear.
Externí odkaz:
https://doaj.org/article/f75281fe53ee452c868a39ecd100241e
Autor:
Craig A. Erickson, Laura Perez-Cano, Ernest V. Pedapati, Eric Painbeni, Gregory Bonfils, Lauren M. Schmitt, Hannah Sachs, Meredith Nelson, Lisa De Stefano, Grace Westerkamp, Adriano L. S. de Souza, Oliver Pohl, Offir Laufer, Gil Issachar, Thomas Blaettler, Jean-Marc Hyvelin, Lynn A. Durham
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1430 (2024)
This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast and bumetanide, tailored for the treatment of a clinically and biologically defined subgroup of patients with Autism Spectrum Disorder (ASD), namely ASD Phen
Externí odkaz:
https://doaj.org/article/556065b7a5b1478ba636739bd3b500ac
Publikováno v:
Journal of Clinical and Translational Science, Vol 8 (2024)
Despite having the same underlying genetic etiology, individuals with the same syndromic form of intellectual developmental disability (IDD) show a large degree of interindividual differences in cognition and IQ. Research indicates that up to 80% of
Externí odkaz:
https://doaj.org/article/911192e3613e4418ba9e01e2290d25cf
Autor:
Rui Liu, Ernest V. Pedapati, Lauren M. Schmitt, Rebecca C. Shaffer, Elizabeth G. Smith, Kelli C. Dominick, Lisa A. DeStefano, Grace Westerkamp, Paul Horn, John A. Sweeney, Craig A. Erickson
Publikováno v:
Biomarkers in Neuropsychiatry, Vol 9, Iss , Pp 100070- (2023)
Objective: Fragile X Syndrome (FXS) is the leading monogenic cause of intellectual disability and autism spectrum disorder. Currently, there are no established biomarkers for predicting and monitoring drug effects in FXS, and no approved therapies ar
Externí odkaz:
https://doaj.org/article/a41cc6c4f4cf44a890ee1a4e9b07148c
Autor:
Lauren M. Schmitt, Elizabeth G. Smith, Ernest V. Pedapati, Paul S. Horn, Meredith Will, Martine Lamy, Lillian Barber, Joe Trebley, Kevin Meyer, Mark Heiman, Korbin H. J. West, Phoevos Hughes, Sanjeev Ahuja, Craig A. Erickson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by core impairments in social communication as well as restricted, repetitive patterns of behavior and/or interests. Individuals with ASD, which includes about 2%
Externí odkaz:
https://doaj.org/article/2770a27e6a904544bc655818432bdc53
Autor:
Devan Straub, Lauren M. Schmitt, Anna E. Boggs, Paul S. Horn, Kelli C. Dominick, Christina Gross, Craig A. Erickson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Fragile X syndrome (FXS) is the most common inherited intellectual disability. FXS is caused by a trinucleotide repeat expansion in the 5′ untranslated region of the FMR1 gene, which leads to gene methylation, transcriptional silencing, an
Externí odkaz:
https://doaj.org/article/650bba68123740748f86782c2d384021