Výsledky vyhledávání - "Lauren M Popov"

Akademický článek

Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages

Autor: Jonathan M Budzik, Danielle L Swaney, David Jimenez-Morales, Jeffrey R Johnson, Nicholas E Garelis, Teresa Repasy, Allison W Roberts, Lauren M Popov, Trevor J Parry, Dexter Pratt, Trey Ideker, Nevan J Krogan, Jeffery S Cox

Publikováno v: eLife, Vol 9 (2020)

Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostasis, but how these distinct cellular fates are triggered by environmental cues is poorly understood. To uncover how primary murine macrophages respond to

Externí odkaz: https://doaj.org/article/cde5e721c9b14b919299582e8f3eddb4

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Akademický článek

Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond

Autor: Allison W Roberts, Lauren M Popov, Gabriel Mitchell, Krystal L Ching, Daniel J Licht, Guillaume Golovkine, Gregory M Barton, Jeffery S Cox

Publikováno v: eLife, Vol 8 (2019)

Macrophages play critical roles in immunity, development, tissue repair, and cancer, but studies of their function have been hampered by poorly-differentiated tumor cell lines and genetically-intractable primary cells. Here we report a facile system

Externí odkaz: https://doaj.org/article/fd6276c25bcd4e448a17af0bee440ba2

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Akademický článek

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes

Autor: Jennifer H. Lumb, Qin Li, Lauren M. Popov, Siyuan Ding, Marie T. Keith, Bryan D. Merrill, Harry B. Greenberg, Jin Billy Li, Jan E. Carette

Publikováno v: Cell Reports, Vol 20, Iss 4, Pp 819-831 (2017)

The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; howe

Externí odkaz: https://doaj.org/article/365eb4a5ed964921a8174395e38e95a5

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Akademický článek

A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity

Autor: Jimit Shah, Florian Rouaud, Diego Guerrera, Ekaterina Vasileva, Lauren M. Popov, William L. Kelley, Eric Rubinstein, Jan E. Carette, Manuel R. Amieva, Sandra Citi

Publikováno v: Cell Reports, Vol 25, Iss 8, Pp 2132-2147.e7 (2018)

Summary: We previously identified PLEKHA7 and other junctional proteins as host factors mediating death by S. aureus α-toxin, but the mechanism through which junctions promote toxicity was unclear. Using cell biological and biochemical methods, we n

Externí odkaz: https://doaj.org/article/1cb104ff748d4600b32198434a057298

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IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus

Autor: Frédéric Fontaine, Lukas Stulik, Stephen J. Galli, Nicolas Gaudenzio, Karin Lakovits, Thomas Marichal, Riccardo Sibilano, Arvand Haschemi, Manuel R. Amieva, Martin L. Watzenboeck, Sylvia Knapp, Philipp Starkl, Lauren M. Popov, Laurent L. Reber, Anastasiya Hladik, André C. Mueller, Sophie Zahalka, Mariem Radhouani

Publikováno v: Immunity
Immunity, Elsevier, 2020, 53 (6), pp.1333. ⟨10.1016/j.immuni.2020.11.012⟩
Immunity, Elsevier, 2020, 53 (4), pp.793-804. ⟨10.1016/j.immuni.2020.08.002⟩

International audience; Allergies are considered to represent mal-directed type 2 immune responses against mostly innocuous exogenous compounds. Immunoglobulin E (IgE) antibodies are a characteristic feature of allergies and mediate hypersensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748d3ddf8210d76bab7a2dbd21c1e6e4
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03149668