Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lauren M Fox"'
Autor:
Alex C D Salyer, Giuseppe Caruso, Karishma K Khetani, Lauren M Fox, Subbalakshmi S Malladi, Sunil A David
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149848 (2016)
Small-molecule agonists have been identified for TLR7, TLR8, TLR4 and TLR2 thus far, and chemotypes other than those of canonical ligands are yet to be explored for a number of innate immune receptors. The discovery of novel immunostimulatory molecul
Externí odkaz:
https://doaj.org/article/fac84ee9b507428ca2994eb487d43eb8
Publikováno v:
American Journal of Health-System Pharmacy. 76:2080-2086
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7325c8538a9100033af020de2384e734
https://doi.org/10.1093/ajhp/zxz244
https://doi.org/10.1093/ajhp/zxz244
Autor:
Toshiyuki Shimizu, Karishma K. Khetani, Luke J. Smith, Umeharu Ohto, Nijunj M. Shukla, Sunil A. David, Giuseppe Caruso, Lauren M. Fox, H. Tanji, Mallesh Beesu, Alex C. D. Salyer
Publikováno v:
Journal of Medicinal Chemistry. 59:3311-3330
Activation of human toll-like receptor-8 (TLR8), expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells, evokes a distinct cytokine profile which favors the development of Type 1 helper T cells. Part-structures of the 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d064385cb0983f1bb628320027e550c
https://doi.org/10.1021/acs.jmedchem.6b00023
https://doi.org/10.1021/acs.jmedchem.6b00023
Autor:
Subbalakshmi S. Malladi, Cassandra D. Jones, Sunil A. David, Anshuman Dixit, Lauren M. Fox, Mallesh Beesu
Publikováno v:
Journal of Medicinal Chemistry
Toll-like receptor (TLR)-8 agonists strongly induce the production of T helper 1-polarizing cytokines and may therefore serve as promising candidate vaccine adjuvants, especially for the very young and the elderly. Earlier structure-based ligand desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326225f4f62c617ad89ebd758291c323
https://doi.org/10.1021/jm500701q
https://doi.org/10.1021/jm500701q
Autor:
Diptesh Sil, Toshiyoki Shimizu, Hari Prasad Kokatla, Umeharu Ohto, Subbalakshmi S. Malladi, H. Tanji, Lauren M. Fox, Sunil A. David
Publikováno v:
ChemMedChem. 9:719-723
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds might be promising candidate vaccine adjuvants. Recently, a C2-butyl furo[2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dfa0ea348663b83fdfb1c506acec89
https://doi.org/10.1002/cmdc.201300573
https://doi.org/10.1002/cmdc.201300573
Autor:
Karishma K. Khetani, Lauren M. Fox, Giuseppe Caruso, Alex C. D. Salyer, Sunil A. David, Subbalakshmi S. Malladi
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149848 (2016)
PLoS ONE
PLoS ONE
Small-molecule agonists have been identified for TLR7, TLR8, TLR4 and TLR2 thus far, and chemotypes other than those of canonical ligands are yet to be explored for a number of innate immune receptors. The discovery of novel immunostimulatory molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aef4ff343470d9fea92ebc5090080ba
http://europepmc.org/articles/PMC4769227?pdf=render
http://europepmc.org/articles/PMC4769227?pdf=render
Autor:
Breanna M. Crall, Subbalakshmi S. Malladi, Lauren M. Fox, Alec R. Hermanson, Euna Yoo, Rajalakshmi Balakrishna, Sunil A. David
Publikováno v:
Organicbiomolecular chemistry. 11(38)
Engagement of TLR7 in plasmacytoid dendritic cells leads to the induction of IFN-α/β which plays essential functions in the control of adaptive immunity. We had previously examined structure-activity relationships (SAR) in TLR7/8-agonistic imidazoq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac988196697686037265dbadd3e877a
https://pubmed.ncbi.nlm.nih.gov/23974333
https://pubmed.ncbi.nlm.nih.gov/23974333
Autor:
Rajalakshmi Balakrishna, Alec R. Hermanson, Lauren M. Fox, Subbalakshmi S. Malladi, Diptesh Sil, Xinkun Wang, Sunil A. David, Anshuman Dixit, Hari Prasad Kokatla
Publikováno v:
Journal of medicinal chemistry. 56(17)
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0540cf30c3f85d1d102ff58e8e46af
https://pubmed.ncbi.nlm.nih.gov/23899291
https://pubmed.ncbi.nlm.nih.gov/23899291
Autor:
Alec R. Hermanson, Seth W. Connelly, Lauren M. Fox, Sunil A. David, Deepak B. Salunke, Nikunj M. Shukla
Publikováno v:
Journal of medicinal chemistry. 56(14)
Antigens in modern subunit vaccines are largely soluble and poorly immunogenic proteins inducing relatively short-lived immune responses. Appropriate adjuvants initiate early innate immune responses, amplifying subsequent adaptive immune responses. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be64cf045dd545db53ba95062cae062
https://pubmed.ncbi.nlm.nih.gov/23795818
https://pubmed.ncbi.nlm.nih.gov/23795818
Autor:
Diptesh Sil, Cameron F. Ng, Euna Yoo, Lauren M. Fox, Hari Prasad Kokatla, Deepak B. Salunke, Subbalakshmi S. Malladi, Rajalakshmi Balakrishna, Sunil A. David
Publikováno v:
Organic & Biomolecular Chemistry. 11:1179
Toll-like receptor (TLR)-8 agonists typified by the 2-alkylthiazolo[4,5-c]quinolin-4-amine (CL075) chemotype are uniquely potent in activating adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84aa19e69281b659972dae1e7b49ab4
https://doi.org/10.1039/c2ob26705e
https://doi.org/10.1039/c2ob26705e