Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Lauren M Aleksunes"'
Autor:
John Rooney, Keiyu Oshida, Naresh Vasani, Beena Vallanat, Natalia Ryan, Brian N Chorley, Xuting Wang, Douglas A Bell, Kai C Wu, Lauren M Aleksunes, Curtis D Klaassen, Thomas W Kensler, J Christopher Corton
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200004 (2018)
The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function. Computational approaches wer
Externí odkaz:
https://doaj.org/article/12b78834e2874996bc7bdf6228ed92c1
Autor:
Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0112655 (2015)
The nuclear receptor family member peroxisome proliferator-activated receptor α (PPARα) is activated by therapeutic hypolipidemic drugs and environmentally-relevant chemicals to regulate genes involved in lipid transport and catabolism. Chronic act
Externí odkaz:
https://doaj.org/article/9dc481cc445a4ac4b7d26cdc2f1b3254
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract The risk of a terrorist attack in the United States has created challenges on how to effectively treat toxicities that result from exposure to chemical weapons. To address this concern, the United States has organized a trans‐agency initia
Externí odkaz:
https://doaj.org/article/757541ea52bd4086b54d42d534ac7d85
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 109-109 (2024)
OBJECTIVES/GOALS: Harmful algal blooms (HABs) are increasing in both frequency and intensity due to climate change. HABs release the toxin microcystin-LR (MC-LR) which enters cells via organic anion-transporting polypeptides (OATPs). In this study, w
Externí odkaz:
https://doaj.org/article/4239bcd6bc8747afa14fc426795dde76
Autor:
Abigail Lazofsky, Anita Brinker, Ruby Gupta, Emily Barrett, Lauren M. Aleksunes, Zorimar Rivera-Núñez, Brian Buckley
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e16940- (2023)
Zearalenone and its metabolites, a group of endocrine disrupting mycotoxins, have been linked to adverse reproductive health effects. They cross the placental barrier, potentially reaching the fetus. In this study, we adapted and optimized our protoc
Externí odkaz:
https://doaj.org/article/860959ea07064e26a831be515840f5e1
Autor:
Zorimar Rivera-Núñez, Megan Hansel, Camila Capurro, Danielle Kozlosky, Christina Wang, Cathleen L. Doherty, Brian Buckley, Pamela Ohman-Strickland, Richard K. Miller, Thomas G. O’Connor, Lauren M. Aleksunes, Emily S. Barrett
Publikováno v:
Toxics, Vol 11, Iss 7, p 589 (2023)
Cadmium exposure has been associated with adverse perinatal outcomes. One possible mechanism is endocrine disruption. Studies of non-pregnant adults suggest that cadmium impacts androgen production; here, we examined these associations during pregnan
Externí odkaz:
https://doaj.org/article/e1be5ec65e22499fa16865694e4f8927
Autor:
Blessy George, Xia Wen, Nickie Mercke, Madeleine Gomez, Cindy O’Bryant, Daniel W. Bowles, Yichun Hu, Susan L. Hogan, Melanie S. Joy, Lauren M. Aleksunes
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 571-576 (2020)
Proteins secreted into urine following tubular injury are being increasingly used as biomarkers of clinical and subclinical nephrotoxicity. In the present study, we sought to characterize the time-dependent urinary excretion of three promising biomar
Externí odkaz:
https://doaj.org/article/271201962f0e4c8eb0f71bfffcb20e5a
Autor:
Barrett, Zorimar Rivera-Núñez, Megan Hansel, Camila Capurro, Danielle Kozlosky, Christina Wang, Cathleen L. Doherty, Brian Buckley, Pamela Ohman-Strickland, Richard K. Miller, Thomas G. O’Connor, Lauren M. Aleksunes, Emily S.
Publikováno v:
Toxics; Volume 11; Issue 7; Pages: 589
Cadmium exposure has been associated with adverse perinatal outcomes. One possible mechanism is endocrine disruption. Studies of non-pregnant adults suggest that cadmium impacts androgen production; here, we examined these associations during pregnan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::1f5cafed86d5fdfb60bb0d7de8d2d12c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6439 (2021)
The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5-HT3 antagonist drug used to prevent nausea and vomiting, can inhibit OCT2-
Externí odkaz:
https://doaj.org/article/00318440cf3b4bc0a5adedc0c6a4566e
Autor:
Michael J. Hafey, Lauren M. Aleksunes, Christy C. Bridges, Kenneth R. Brouwer, Huan‐Chieh Chien, Elaine M. Leslie, Shuiying Hu, Yang Li, Jinshan Shen, Alex Sparreboom, Jason Sprowl, Donald Tweedie, Yurong Lai
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:527-539
Over the last decade, significant progress been made in elucidating the role of membrane transporters in altering drug disposition, with important toxicological consequences due to changes in localized concentrations of compounds. The topic of "Trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c870fc81df45a14ee24cb1b9a54eb029
https://doi.org/10.1002/cpt.2638
https://doi.org/10.1002/cpt.2638