Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lauren LeBon"'
Autor:
Qi Hao, Jin-Mi Heo, Boguslaw P. Nocek, Kevin G. Hicks, Vincent S. Stoll, Clint Remarcik, Sean Hackett, Lauren LeBon, Rinku Jain, Dan Eaton, Jared Rutter, Yao Liang Wong, Carmela Sidrauski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link betw
Externí odkaz:
https://doaj.org/article/7dab3274bc6948168fa0acd7979be94e
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Publikováno v:
eLife, Vol 7 (2018)
eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates global protein synthesis and upreg
Externí odkaz:
https://doaj.org/article/83d84271b4b942fab5fece615d525f1f
Publikováno v:
eLife, Vol 3 (2014)
Externí odkaz:
https://doaj.org/article/8c52283c0de5471196f2cf36b85831e9
Publikováno v:
eLife, Vol 3 (2014)
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notc
Externí odkaz:
https://doaj.org/article/44f737d56ed8479c9124b2651908442d
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 6, p e1002069 (2011)
Developmental patterning requires juxtacrine signaling in order to tightly coordinate the fates of neighboring cells. Recent work has shown that Notch and Delta, the canonical metazoan juxtacrine signaling receptor and ligand, mutually inactivate eac
Externí odkaz:
https://doaj.org/article/3398087b8abd41889f4701cd290c3d7e
Autor:
Dan Eaton, Vincent S Stoll, Sean R. Hackett, Jared Rutter, Jin-Mi Heo, Clint Remarcik, Rinku Jain, Qi Hao, Carmela Sidrauski, Lauren LeBon, Kevin G. Hicks, Yao Liang Wong, Boguslaw Nocek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
The multi-subunit translation initiation factor eIF2B is a control node for protein synthesis. eIF2B activity is canonically modulated through stress-responsive phosphorylation of its substrate eIF2. The eIF2B regulatory subcomplex is evolutionarily
Autor:
Nicole V Haste, Diana Donnelly-Roberts, Swathi Krishnan, Lauren LeBon, Jennifer M. Frost, Fiona E. McAllister, Andrea T. Ireland, Yao Liang Wong, Carmela Sidrauski, Stephan Riedmaier, Michael J. Dart, Kathy L. Kohlhaas, Lei Shi, Nimrod D. Rubinstein, Ana M. Basso, Janani Prakash, Kathleen A. Martin, Andrew M. Swensen, Arthur L. Nikkel, Jonathon J. O’Brien, Margaret Ann Roy, Holly M. Robb
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Autor:
Diana L. Donnelly-Roberts, Ana M. Basso, Arthur L. Nikkel, Andrea T. Ireland, Jennifer M. Frost, Lauren LeBon, Carmela Sidrauski, Stephan Riedmaier, Nimrod D. Rubinstein, Holly M. Robb, Kathleen A. Martin, Nicole V Haste, Fiona E. McAllister, Swathi Krishnan, Lei Shi, Margaret Ann Roy, Andrew M. Swensen, Janani Prakash, Jonathon J. O’Brien, Kathy L. Kohlhaas, Yao Liang Wong, Michael J. Dart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebd2110389786065142053652d6bb1f
https://doi.org/10.7554/elife.42940.036
https://doi.org/10.7554/elife.42940.036
Autor:
Ana M. Basso, Nimrod D. Rubinstein, Arthur L. Nikkel, Fiona E. McAllister, Jennifer M. Frost, Michael J. Dart, Janani Prakash, Diana Donnelly-Roberts, Kathleen A. Martin, Kathy L. Kohlhaas, Andrew M. Swensen, Lauren LeBon, Lei Shi, Jonathon J. O’Brien, Yao Liang Wong, Stephan Riedmaier, Swathi Krishnan, Nicole V Haste, Carmela Sidrauski, Holly M. Robb
The Integrated Stress Response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792bd23e32b80b51dd87fa6b42310ee3