Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lauren Langbein"'
Autor:
Weijia Cai, Liya Su, Lili Liao, Zongzhi Z. Liu, Lauren Langbein, Essel Dulaimi, Joseph R. Testa, Robert G. Uzzo, Zhijiu Zhong, Wei Jiang, Qin Yan, Qing Zhang, Haifeng Yang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Acetylation of p53 is critical for its transcriptional activity and its tumour suppressive function. Here, the authors show that PBRM1 is a reader protein for p53′s C-terminal domain acetylation on lysine 382 through its bromodomain 4 and that muta
Externí odkaz:
https://doaj.org/article/4c56454ffebd47ce98598764f25ff35c
Autor:
Lili Liao, Nilda L. Alicea‐Velázquez, Lauren Langbein, Xiaohua Niu, Weijia Cai, Eun‐Ah Cho, Meiling Zhang, Celeste B. Greer, Qin Yan, Michael S. Cosgrove, Haifeng Yang
Publikováno v:
Molecular Oncology, Vol 13, Iss 4, Pp 811-828 (2019)
Polybromo‐1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl‐lysine residues. While BD2 has been found to bind acetylated histone H3 lysin
Externí odkaz:
https://doaj.org/article/c57fd6c15dc2484c9410ea2022415536
Autor:
Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen C Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/a50046e84ed442a683b9fc60b5d5c454
Autor:
Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Publikováno v:
eLife, Vol 7 (2018)
Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains
Externí odkaz:
https://doaj.org/article/469424e6a2dc4921b7e109a9d371cd8e
Autor:
Haifeng Yang, Robert G. Uzzo, Qing Zhang, Zongzhi Liu, Qin Yan, Lauren Langbein, Weijia Cai, Liya Su, Wei Jiang, Lili Liao, Essel Dulaimi, Joseph R. Testa, Zhijiu Zhong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) for p53 acetylation remains elusive. PBRM1, the second most highly mutated tumor suppressor gene in kidney ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53805c6e1d098461beefd4df600190d7
https://doaj.org/article/4c56454ffebd47ce98598764f25ff35c
https://doaj.org/article/4c56454ffebd47ce98598764f25ff35c
Autor:
Geetha Jagannathan, Haifeng Yang, Robert G. Uzzo, Zongzhi Liu, Jie Na, Xiaohua Niu, Zhijiu Zhong, Stephen C. Peiper, Yaomin Xu, Essel Dulaimi, Qin Yan, George R. Stark, Wei Jiang, Eun-Ah Cho, Joseph R. Testa, Wesley L. Cai, Weijia Cai, Yuxin Wang, Jianxin Sun, Lili Liao, Lauren Langbein
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46eadc9243b5bd5b04b348bdae2a7bbc
https://elifesciences.org/articles/69256
https://elifesciences.org/articles/69256
Autor:
Qin Yan, Stephen C. Peiper, Zhijiu Zhong, Wesley L. Cai, Lili Liao, Jie Na, Essel Dulaimi, Yaomin Xu, George R. Stark, Weijia Cai, Robert G. Uzzo, Geetha Jagannathan, Wei Jiang, Joseph R. Testa, Haifeng Yang, Xiaohua Niu, Yuxin Wang, Jianxin Sun, Zongzhi Liu, Lauren Langbein, Eun-Ah Cho
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
WhereasVHLinactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, includingPBRM1,KDM5C/JARID1C,SETD2, and/orBAP1, remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82955d21cc46fc032579dfdd28f24252
https://doi.org/10.7554/elife.37925
https://doi.org/10.7554/elife.37925
Autor:
Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f926c3fdf240a3cba5ef2cfa169030a
https://doi.org/10.7554/elife.37925.029
https://doi.org/10.7554/elife.37925.029
Autor:
Lili Liao, Celeste B. Greer, Xiaohua Niu, Nilda L. Alicea-Velázquez, Qin Yan, Michael S. Cosgrove, Meiling Zhang, Lauren Langbein, Haifeng Yang, Weijia Cai, Eun-Ah Cho
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 13, Iss 4, Pp 811-828 (2019)
Molecular Oncology, Vol 13, Iss 4, Pp 811-828 (2019)
Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues. While BD2 has been found to bind acetylated histone H3 lysine 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14d9b2cc1c8238827245e12992ec99f
https://pubmed.ncbi.nlm.nih.gov/30585695
https://pubmed.ncbi.nlm.nih.gov/30585695
Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ece218dbaed28d8777b0cb112faf2c7
https://europepmc.org/articles/PMC5629323/
https://europepmc.org/articles/PMC5629323/