Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lauren L Orefice"'
Autor:
James P Bohnslav, Nivanthika K Wimalasena, Kelsey J Clausing, Yu Y Dai, David A Yarmolinsky, Tomás Cruz, Adam D Kashlan, M Eugenia Chiappe, Lauren L Orefice, Clifford J Woolf, Christopher D Harvey
Publikováno v:
eLife, Vol 10 (2021)
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few
Externí odkaz:
https://doaj.org/article/0490bc2a85ba4831a27480dbae549b72
Autor:
Aniqa Tasnim, Ilayda Alkislar, Richard Hakim, Josef Turecek, Amira Abdelaziz, Lauren L. Orefice, David D. Ginty
Publikováno v:
bioRxiv
Altered somatosensory reactivity is frequently observed among individuals with autism spectrum disorders (ASDs). Here, we report that while multiple mouse models of ASD exhibit aberrant somatosensory behaviors in adulthood, some models exhibit altere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59af97d8ea99ec21a2424bcecc46ac4a
https://europepmc.org/articles/PMC10197556/
https://europepmc.org/articles/PMC10197556/
Publikováno v:
Alusi, G, Berry-Kravis, E, Nelson, D, Orefice, L L & Booker, S A 2022, ' Emerging therapeutic strategies for Fragile X Syndrome : Q &A ', ACS Chemical Neuroscience, vol. 13, no. 24, pp. 3544-3546 . https://doi.org/10.1021/acschemneuro.2c00674
Understanding how best to treat aspects of Fragile X syndrome has the potential to improve the quality of life of affected individuals. Such an effective therapy has, as yet, remained elusive. In this article, we ask those researching or affected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa364e72bb693df2c18fb04f746cbe57
https://hdl.handle.net/20.500.11820/e2c236d6-b517-4f1d-8ae4-9773466eb52f
https://hdl.handle.net/20.500.11820/e2c236d6-b517-4f1d-8ae4-9773466eb52f
Autor:
Kelsey J Clausing, Nivanthika K Wimalasena, Lauren L. Orefice, Yu Y Dai, Adam D Kashlan, Christopher D. Harvey, Clifford J. Woolf, M. Eugenia Chiappe, Tomás Cruz, James P Bohnslav, David A Yarmolinsky
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a40a617760c272491d2595e312df16
https://doi.org/10.7554/elife.63377
https://doi.org/10.7554/elife.63377
Autor:
Christopher D. Harvey, Clifford J. Woolf, David A Yarmolinsky, Lauren L. Orefice, M. Eugenia Chiappe, Nivanthika K Wimalasena, Kelsey J Clausing, Tomás Cruz, James P Bohnslav, Yu Y Dai, Adam D Kashlan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a9150081598d34e2a2c221246f5e81
https://doi.org/10.7554/elife.63377.sa2
https://doi.org/10.7554/elife.63377.sa2
Autor:
Christopher D. Harvey, Clifford J. Woolf, James P Bohnslav, Tomás Cruz, Kelsey J Clausing, Lauren L. Orefice, eugenia chiappe, David A Yarmolinsky, Nivanthika K Wimalasena
Researchers commonly acquire videos of animal behavior and quantify the prevalence of behaviors of interest to study nervous system function, the effects of gene mutations, and the efficacy of pharmacological therapies. This analysis is typically per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59c910378ca828995ccb550a47635ff
https://doi.org/10.1101/2020.09.24.312504
https://doi.org/10.1101/2020.09.24.312504
Autor:
Julia Rhyins, Alan J. Emanuel, Nicole Neubarth, Mark W. Springel, Amira Abdelaziz, Yin Liu, Michelle M. DeLisle, David D. Ginty, Qiyu Zhang, Christopher D. Harvey, Wade G. Regehr, Jan Drugowitsch, Stuart J. Cattel, Chong Guo, Lauren L. Orefice, Brendan P. Lehnert, Michael Iskols, Soo Joong Kim, Annie Handler
Publikováno v:
Science (New York, N.Y.). 368(6497)
Secrets of Meissner corpuscles The Meissner corpuscle, a mechanosensory end organ, was discovered more than 165 years ago and has since been found in the glabrous skin of all mammals, including that on human fingertips. Although prominently featured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a98284fb1a18c30356c60f9480299fd
https://pubmed.ncbi.nlm.nih.gov/32554582
https://pubmed.ncbi.nlm.nih.gov/32554582
Autor:
David D. Ginty, Jacqueline R. Mosko, Maria K. Lehtinen, Michael F. Wells, Mengchen Ye, Shawn M. Mozeika, Aniqa Tasnim, Anda M. Chirila, Guoping Feng, Lauren L. Orefice, Ryann M. Fame, Alan J. Emanuel, Genelle Rankin, Danielle T. Morency
Publikováno v:
PMC
Somatosensory over-reactivity is common among patients with autism spectrum disorders (ASDs) and is hypothesized to contribute to core ASD behaviors. However, effective treatments for sensory over-reactivity and ASDs are lacking. We found distinct so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c68464d35aaab48566be63f4d6bcafe
https://hdl.handle.net/1721.1/126789
https://hdl.handle.net/1721.1/126789
Autor:
Lauren L. Orefice
Publikováno v:
Science. 366:45-46
A role for peripheral sensory neurons in autism pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96be9e12e3645984f50d6bebc79351ab
https://doi.org/10.1126/science.aaz3880
https://doi.org/10.1126/science.aaz3880
Autor:
Shu Ling Chiu, Lauren L. Orefice, Haiqing Zhao, Samer Hattar, Richard L. Huganir, Rejji Kuruvilla, Baoji Xu, Chih Ming Chen, Tara A. LeGates
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(4)
Stability of neuronal connectivity is critical for brain functions, and morphological perturbations are associated with neurodegenerative disorders. However, how neuronal morphology is maintained in the adult brain remains poorly understood. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bc6d0e59b89fb1c87b56c6ddfbc88e
https://pubmed.ncbi.nlm.nih.gov/28069946
https://pubmed.ncbi.nlm.nih.gov/28069946