Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lauren Kosten"'
Autor:
Faraz Moradi, Monica van den Berg, Morteza Mirjebreili, Lauren Kosten, Marleen Verhoye, Mahmood Amiri, Georgios A. Keliris
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107454- (2023)
Summary: The hippocampus plays a vital role in navigation, learning, and memory, and is affected in Alzheimer’s disease (AD). This study investigated the classification of AD-transgenic rats versus wild-type littermates using electrophysiological a
Externí odkaz:
https://doaj.org/article/81df3e93c7ab4ea68a96564a747326ed
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
One of the main challenges in brain research is to link all aspects of brain function: on a cellular, systemic, and functional level. Multimodal neuroimaging methodology provides a continuously evolving platform. Being able to combine calcium imaging
Externí odkaz:
https://doaj.org/article/55dd05bcc7c64f0a89d61193f8d77536
Publikováno v:
Molecular Imaging, Vol 17 (2018)
Detecting changes in metabotropic glutamate receptor 5 (mGluR5) availability through molecular imaging with the positron emission tomography (PET) tracer [ 11 C]ABP688 is valuable for studying dysfunctional glutamate transmission associated with neur
Externí odkaz:
https://doaj.org/article/b5b68957794d440fbc5156fcfaa4a2a3
Autor:
Jeroen Verhaeghe, Daniele Bertoglio, Lauren Kosten, David Thomae, Marleen Verhoye, Annemie Van Der Linden, Leonie Wyffels, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified with the PET radiotracer [11C]ABP688, the methods for reproducible quantification of [11C]AB
Externí odkaz:
https://doaj.org/article/a37fe964a9284659b7c8cdb502919689
Autor:
Daniele Bertoglio, Jeroen Verhaeghe, Lauren Kosten, David Thomae, Annemie Van der Linden, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0206613 (2018)
The positron emission tomography (PET) tracer [18F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for Huntington's disease (HD). In this study we investigated [18F]MNI-659 uptake in the Q175 mo
Externí odkaz:
https://doaj.org/article/6f9a19c7aa1b4a199cf8326019cdbb1c
Autor:
Stephan Missault, Sam De Waegenaere, Lauren Kosten, Annemie Van der Linden, Marleen Verhoye, Georgios A. Keliris
The septohippocampal pathway plays an important role in learning and memory. It projects from the medial septum-vertical limb of the diagonal band of Broca (MSDB) to the hippocampus and provides the latter with its main cholinergic innervation. To as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6a86e8b91dc9e5827a8e3a106e9454
https://doi.org/10.1101/2022.08.02.502516
https://doi.org/10.1101/2022.08.02.502516
Autor:
Faraz Moradi, Monica van den Berg, Morteza Mirjebreili, Lauren Kosten, Marleen Verhoye, Mahmood Amiri, Georgios A. Keliris
The hippocampus is thought to guide navigation and has an essential contribution to learning and memory. Hippocampus is one of the brain regions impaired in Alzheimer’s disease (AD), a neurodegenerative disease with progressive memory impairments a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da8f81390d7f64c04bc128ddbd8db55
https://doi.org/10.1101/2022.07.01.498373
https://doi.org/10.1101/2022.07.01.498373
Autor:
Maarten Timmers, Bernard Sabbe, Steven Staelens, Lauren Kosten, Leonie Wyffels, Sarah Ceyssens, Violette Coppens, Livia De Picker, Jeroen Verhaeghe, Luc Van Nueten, Sigrid Stroobants, Julie Ottoy, Manuel Morrens, Steven Deleye
Publikováno v:
The Journal of nuclear medicine
Activated microglia express the translocator protein (TSPO) on the outer mitochondrial membrane. 18F-PBR111 is a second-generation positron emission tomography (PET) ligand that specifically binds the TSPO, allowing in-vivo visualization and quantifi
Autor:
Lauren Kosten, Stephen Rayport, Susana Mingote, Sigrid Stroobants, Steven Deleye, Leonie Wyffels, Steven Staelens
Publikováno v:
Cellular and molecular neurobiology
Many PET tracers enable determination of fluctuations in neurotransmitter release, yet glutamate specifically can not be visualized in a noninvasive manner. Several studies point to the possibility of visualizing fluctuations in glutamate release by
Autor:
Erik Fransen, Manuel Morrens, Bernard Sabbe, Peter de Boer, Livia De Picker, Lauren Kosten, Violette Coppens, Sigrid Stroobants, Jeroen Verhaeghe, Luc Van Nueten, Steven Deleye, Filip Vanhoenacker, Herbert Oberacher, Julie Ottoy, Maarten Timmers, Ken Op de Beeck, Steven Staelens, Sarah Ceyssens, Leonie Wyffels
Publikováno v:
Brain, behavior, and immunity
Objective To determine whether state-associated changes in microglial activity, measured with translocator-protein positron emission tomography (TSPO PET), can be identified in psychosis patients through longitudinal evaluation of their regional trac