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Autor:
Arthur B. Straughn, Wendy Rodriguez, Jennifer L. Radke, Kennerly S. Patrick, John R. Raymond, Linda V. Nguyen, Lauren Koller
Publikováno v:
Pharmacotherapy. 39(6)
In 2000, the first biphasic modified-release (MR) formulation of methylphenidate (MPH) was approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). An immediate-release (IR) MPH pulse (22% of the dose) facilitates rapid onset of