Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Lauren J. Webb"'
Autor:
Linda Rowland, Henri-Baptiste Marjault, Ola Karmi, DeAna Grant, Lauren J. Webb, Assaf Friedler, Rachel Nechushtai, Ron Elber, Ron Mittler
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Cell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs. We recently reported that a peptide derived from the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy Factor 1 (NAF-1; NAF-144-67), s
Externí odkaz:
https://doaj.org/article/b4d3c35acc764f168760d30991e8cfdd
Publikováno v:
The journal of physical chemistry. B. 126(34)
A physical understanding of membrane permeation and translocation by small, positively charged molecules can illuminate cell penetrating peptide mechanisms of entry and inform drug design. We have previously investigated the permeation of the doubly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21086c11c2395a3bbd1f7157e94c578b
https://pubmed.ncbi.nlm.nih.gov/35997537
https://pubmed.ncbi.nlm.nih.gov/35997537
Publikováno v:
J Phys Chem B
The cell-penetrating peptide NAF-1 has recently emerged as a promising candidate for selective penetration and destruction of cancer cells. It displays numerous membrane-selective behaviors including cell-specific uptake and organelle-specific degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83668476b7efb8d2ac0dda46c6e7dbd5
https://doi.org/10.1021/acs.jpcb.2c08076
https://doi.org/10.1021/acs.jpcb.2c08076
Autor:
Paul R. Handali, Lauren J. Webb
Publikováno v:
ACS Applied Bio Materials. 6:209-217
Immobilizing enzymes onto abiological surfaces is a key step for developing protein-based technologies that can be useful for applications such as biosensors and biofuel cells. A central impediment for the advancement of this effort is a lack of gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471f6ce1413a83ff6698c64fc07ee588
https://doi.org/10.1021/acsabm.2c00834
https://doi.org/10.1021/acsabm.2c00834
Publikováno v:
The Journal of Physical Chemistry B. 126:7806-7817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::156bd70e455382218e4e72ce29943068
https://doi.org/10.1021/acs.jpcb.2c03642
https://doi.org/10.1021/acs.jpcb.2c03642
Autor:
Alfredo E. Cardenas, Chad I. Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J. Webb, Ron Elber
Publikováno v:
J Phys Chem B
Cell penetrating peptides (CPPs) facilitate translocation across biological membranes and are of significant biological and medical interest. Several CPPs can permeate into specific cells and organelles. We examine the incorporation and translocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739ad8e77c847be3c64f9052d73032e3
https://pubmed.ncbi.nlm.nih.gov/35388695
https://pubmed.ncbi.nlm.nih.gov/35388695
Autor:
Joshua M. Correira, Lauren J. Webb
Publikováno v:
Langmuir. 38:3501-3513
Enzyme activity is the basis for many biosensors where a catalytic event is used to detect the presence and amount of a biomolecule of interest. To create a practical point-of-care biosensor, these enzymes need to be removed from their native cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61871d9ab94d00c085849e2ab6363e49
https://doi.org/10.1021/acs.langmuir.1c03399
https://doi.org/10.1021/acs.langmuir.1c03399
Autor:
Yang Sung Sohn, Anat losub-Amir, Alfredo E. Cardenas, Ola Karmi, Merav Darash Yahana, Tal Gruman, Linda Rowland, Henri-Baptiste Marjault, Lauren J. Webb, Ron Mittler, Ron Elber, Assaf Friedler, Rachel Nechushtai
Publikováno v:
Chemical science. 13(23)
An effective anti-cancer therapy should exclusively target cancer cells and trigger in them a broad spectrum of cell death pathways that will prevent avoidance. Here, we present a new approach in cancer therapy that specifically targets the mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf26bb28bae5e3935626d4de075e194
https://pubmed.ncbi.nlm.nih.gov/35774163
https://pubmed.ncbi.nlm.nih.gov/35774163
Autor:
Michael J. Lucas, Henry S. Pan, Eric J. Verbeke, Gina Partipilo, Ethan C. Helfman, Leah Kann, Benjamin K. Keitz, David W. Taylor, Lauren J. Webb
Publikováno v:
The journal of physical chemistry. B. 126(11)
Amyloid peptides nucleate from monomers to aggregate into fibrils through primary nucleation. Pre-existing fibrils can then act as seeds for additional monomers to fibrillize through secondary nucleation. Both nucleation processes occur simultaneousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b8a069b41aab50ac84b18f9888486a
https://pubmed.ncbi.nlm.nih.gov/35276047
https://pubmed.ncbi.nlm.nih.gov/35276047
Publikováno v:
The Journal of Physical Chemistry B. 124:3387-3399
Electric fields are fundamentally important to biological phenomena, but are difficult to measure experimentally or predict computationally. Changes in pKa of titratable residues have long been used to report on local electrostatic fields in proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212560acb24f5252a8cd443df3e1d14b
https://doi.org/10.1021/acs.jpcb.0c00747
https://doi.org/10.1021/acs.jpcb.0c00747