Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.

Autor: Elizabeth K Speliotes, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim, Cameron D Palmer, Vilmundur Gudnason, Gudny Eiriksdottir, Melissa E Garcia, Lenore J Launer, Michael A Nalls, Jeanne M Clark, Braxton D Mitchell, Alan R Shuldiner, Johannah L Butler, Marta Tomas, Udo Hoffmann, Shih-Jen Hwang, Joseph M Massaro, Christopher J O'Donnell, Dushyant V Sahani, Veikko Salomaa, Eric E Schadt, Stephen M Schwartz, David S Siscovick, NASH CRN, GIANT Consortium, MAGIC Investigators, Benjamin F Voight, J Jeffrey Carr, Mary F Feitosa, Tamara B Harris, Caroline S Fox, Albert V Smith, W H Linda Kao, Joel N Hirschhorn, Ingrid B Borecki, GOLD Consortium

Publikováno v: PLoS Genetics, Vol 7, Iss 3, p e1001324 (2011)

Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analys

Externí odkaz: https://doaj.org/article/c5813c26c983461e8c878bf0d8d9f7b5

Associations of Visceral and Liver Fat With the Metabolic Syndrome Across the Spectrum of Obesity: The AGES-Reykjavik Study

Autor: Annemarie Koster, Lenore J. Launer, Lauren J. Kim, Tamara B. Harris, Sigurdur Sigurdsson, Mike A. Nalls, Melissa E. Garcia, Vilmundur Gudnason, Birna Jonsdottir, Paulo H.M. Chaves, Gudny Eiriksdottir

Publikováno v: Obesity, 19(6), 1265-1271. Wiley

Visceral adipose tissue (VAT) is a key pathogenic fat depot in the metabolic syndrome (MetS), but liver fat (LF) may also play an important role. We evaluated associations of VAT and LF with MetS in normal weight, overweight, and obese men and women

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc3d1e314833295f4a26e1be12c8d57
https://doi.org/10.1038/oby.2010.291

Cardiac Troponin I Predicts Short-Term Mortality in Vascular Surgery Patients

Autor: Daniel W. Chan, Elizabeth A. Martinez, Lauren J. Kim, Nauder Faraday, G. Melville Williams, Bruce A. Perler, Peter J. Pronovost, Todd Dorman, Lee A. Fleisher

Publikováno v: Circulation. 106:2366-2371

Background— Cardiac troponin I (cTnI) is a highly sensitive and specific marker for myocardial injury that predicts outcomes in patients with acute coronary syndromes. Cardiovascular complications are the leading cause of morbidity and mortality in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1693306ceb2f81afcaceddacbd3cb071
https://doi.org/10.1161/01.cir.0000036016.52396.bb

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Autor: Peter Vollenweider, Ruth J. F. Loos, Sarah H. Wild, Unnur Styrkarsdottir, Talin Haritunians, Christian Gieger, Gudmar Thorleifsson, Mao Fu, Stephen O'Rahilly, Markku Laakso, Steve E. Humphries, Braxton D. Mitchell, Mika Kivimäki, John C. Chambers, Yanhua Zhou, Cornelia M. van Duijn, Samuli Ripatti, Robert Luben, Jing Hua Zhao, Veikko Salomaa, Tatjana Škarić-Jurić, José Manuel Fernández-Real, Vilmundur Gudnason, Jeffery R. O'Connell, Robert C. Kaplan, Emmi Tikkanen, Elizabeth K. Speliotes, Sailaja Vedantam, Leonie C. Jacobs, Caroline Hayward, Östen Ljunggren, Bo Isomaa, Albert Hofman, Unnur Thorsteinsdottir, Tuomas O. Kilpeläinen, Nicole L. Glazer, Ben A. Oostra, Vincent Mooser, Magnus Karlsson, Douglas P. Kiel, André G. Uitterlinden, Alan F. Wright, Gérard Waeber, Fernando Rivadeneira, H-Erich Wichmann, Angela Döring, Tamara B. Harris, Leif Groop, Gudny Eiriksdottir, Nicole Soranzo, Philippa J. Talmud, Claes Ohlsson, Erik Ingelsson, Nicholas J. Wareham, Kari Stefansson, Ci Song, Robert K. Semple, Bruce M. Psaty, David B. Savage, Harry Campbell, Meena Kumari, Norman Klopp, Alena Stančáková, Antti Jula, Alice M. Arnold, Najaf Amin, Bjarni V. Halldorsson, Laura Pascoe, Yongmei Liu, Karol Estrada, Mark Walker, Ann-Christine Syvänen, Jaspal S. Kooner, James F. Wilson, Belén Peral, Mary F. Feitosa, Johanna Kuusisto, Melissa Garcia, L. Adrienne Cupples, Albert V. Smith, Tim D. Spector, John-Olov Jansson, Candace Guiducci, Joel N. Hirschhorn, Alan R. Shuldiner, Inês Barroso, Francis M. Finucane, Deborah J. Clegg, Ingrid B. Borecki, Weihua Zhang, Kathryn Davis, Massimo Mangino, Caroline S. Fox, So-Youn Shin, Leena Peltonen, Lauren J. Kim, Eric E. Schadt, Kijoung Song, José María Moreno, Mattias Lorentzon, Gunnar Sigurdsson, Kay-Tee Khaw, Claudia Langenberg, Markus Perola, Liesbeth Vandenput, Jacques S. Beckmann, Barbara McKnight, Satu Männistö, Antonio Vidal-Puig, Igor Rudan, Brigitte Kühnel, Jian'an Luan, Yurii S. Aulchenko, Dan Mellström, M. Carola Zillikens, Janina S. Ried, David Karasik

Publikováno v: Kilpeläinen, T O, Zillikens, M C, Stančákova, A, Finucane, F M, Ried, J S, Langenberg, C, Zhang, W, Beckmann, J S, Luan, J, Vandenput, L, Styrkarsdottir, U, Zhou, Y, Smith, A V, Zhao, J-H, Amin, N, Vedantam, S, Shin, S-Y, Haritunians, T, Fu, M, Feitosa, M F, Kumari, M, Halldorsson, B V, Tikkanen, E, Mangino, M, Hayward, C, Song, C, Arnold, A M, Aulchenko, Y S, Oostra, B A, Campbell, H, Cupples, L A, Davis, K E, Döring, A, Eiriksdottir, G, Estrada, K, Fernández-Real, J M, Garcia, M, Gieger, C, Glazer, N L, Guiducci, C, Hofman, A, Humphries, S E, Isomaa, B, Jacobs, L C, Jula, A, Karasik, D, Karlsson, M K, Khaw, K-T, Kim, L J, Kivimäki, M, Klopp, N, Kühnel, B, Kuusisto, J, Liu, Y, Ljunggren, O, Lorentzon, M, Luben, R N, McKnight, B, Mellström, D, Mitchell, B D, Mooser, V, Moreno, J M, Männistö, S, O'Connell, J R, Pascoe, L, Peltonen, L, Peral, B, Perola, M, Psaty, B M, Salomaa, V, Savage, D B, Semple, R K, Skaric-Juric, T, Sigurdsson, G, Song, K S, Spector, T D, Syvänen, A-C, Talmud, P J, Thorleifsson, G, Thorsteinsdottir, U, Uitterlinden, A G, van Duijn, C M, Vidal-Puig, A, Wild, S H, Wright, A F, Clegg, D J, Schadt, E, Wilson, J F, Rudan, I, Ripatti, S, Borecki, I B, Shuldiner, A R, Ingelsson, E, Jansson, J-O, Kaplan, R C, Gudnason, V, Harris, T B, Groop, L, Kiel, D P, Rivadeneira, F, Walker, M, Barroso, I, Vollenweider, P, Waeber, G, Chambers, J C, Kooner, J S, Soranzo, N, Hirschhorn, J N, Stefansson, K, Wichmann, H-E, Ohlsson, C, O'Rahilly, S, Wareham, N J, Speliotes, E K, Fox, C S, Laakso, M & Loos, R J F 2011, ' Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile ', Nature Genetics, vol. 43, no. 8, pp. 753-760 . https://doi.org/10.1038/ng.866
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Nature Genetics
Nature Genetics, vol. 43, no. 8, pp. 753-760
Nature Genetics, 43(8), 753-U58. Nature Publishing Group
Nature genetics
Nature Genetics; Vol 43

El pdf del artículo es el manuscrito de autor: PMC3262230.-- et al.
Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7acc24ca98de752f2e5f6cf90a24e4
https://www.bib.irb.hr/523768

Lumbar sympathetic block for sympathetically maintained pain: changes in cutaneous temperatures and pain perception

Autor: Lauren J. Kim, Hossam K. El-Rahmany, Kha M. Tran, Steven M. Frank, Srinivasa N. Raja, Brian Vu

Publikováno v: Anesthesia and analgesia. 90(6)

Lumbar sympathetic block (LSB) is used in the management of sympathetically maintained pain states. We characterized cutaneous temperature changes over the lower extremities after LSB. Additionally, we examined the effects of iohexol, a radio-opaque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8ac911693fefb602303eff3919528
https://pubmed.ncbi.nlm.nih.gov/10825327