Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lauren I. Aronson"'
Autor:
Lauren I. Aronson, Faith E. Davies
Publikováno v:
Haematologica, Vol 97, Iss 8 (2012)
Myeloma is a malignancy of the antibody-producing plasma cells and, as such, these cells synthesize large quantities of unfolded or misfolded immunoglobulin. The build-up of excess protein triggers a number of downstream signal transduction cascades,
Externí odkaz:
https://doaj.org/article/e1677d6d688c46dfaade68a6f1d588ea
Autor:
Irene Y. Chong, Christopher J. Lord, Wojciech Niedzwiedz, Syed Haider, Andres Cervantes, Johann de Bono, Stephen J. Pettitt, Jyoti Choudhary, Theodoros Roumeliotis, Ana Ferreira, Ruth Riisnaes, Bora Gurel, Frank T. Zenke, Astrid Zimmermann, Rachel Brough, Ronan Broderick, Malgorzata Dylewska, Feifei Song, John Alexander, Jadwiga Nieminuszczy, Dragomir B. Krastev, Lauren I. Aronson, Marta J. Llorca-Cardenosa
Supplementary Table from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7bde9d3ff1abb9ef60efb2134cb7ae
https://doi.org/10.1158/0008-5472.22433010
https://doi.org/10.1158/0008-5472.22433010
Autor:
Irene Y. Chong, Christopher J. Lord, Wojciech Niedzwiedz, Syed Haider, Andres Cervantes, Johann de Bono, Stephen J. Pettitt, Jyoti Choudhary, Theodoros Roumeliotis, Ana Ferreira, Ruth Riisnaes, Bora Gurel, Frank T. Zenke, Astrid Zimmermann, Rachel Brough, Ronan Broderick, Malgorzata Dylewska, Feifei Song, John Alexander, Jadwiga Nieminuszczy, Dragomir B. Krastev, Lauren I. Aronson, Marta J. Llorca-Cardenosa
Supplementary Data from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1587dcc4a0be2c2d50162b142e37df4
https://doi.org/10.1158/0008-5472.22433013
https://doi.org/10.1158/0008-5472.22433013
Autor:
Irene Y. Chong, Christopher J. Lord, Wojciech Niedzwiedz, Syed Haider, Andres Cervantes, Johann de Bono, Stephen J. Pettitt, Jyoti Choudhary, Theodoros Roumeliotis, Ana Ferreira, Ruth Riisnaes, Bora Gurel, Frank T. Zenke, Astrid Zimmermann, Rachel Brough, Ronan Broderick, Malgorzata Dylewska, Feifei Song, John Alexander, Jadwiga Nieminuszczy, Dragomir B. Krastev, Lauren I. Aronson, Marta J. Llorca-Cardenosa
Gastric cancer represents the third leading cause of global cancer mortality and an area of unmet clinical need. Drugs that target the DNA damage response, including ATR inhibitors (ATRi), have been proposed as novel targeted agents in gastric cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e563c09a484cf966f330a341b09c73e
https://doi.org/10.1158/0008-5472.c.6514290.v1
https://doi.org/10.1158/0008-5472.c.6514290.v1
Autor:
Isma Rana, David Watkins, Lauren I. Aronson, Naureen Starling, Sheela Rao, Ian Chau, Retchel Lazaro-Alcausi, Irene Chong, Ruwaida Begum, Hanna Bryant, Marta Llorca Cardenosa, Michael Davidson, Monica Terlizzo, Sanna Hulkki-Wilson, John Swansbury, Julie Howard-Reeves, David Cunningham, Christopher J. Lord, Gina Brown, Eftheleria Kalaitzaki, Andrew Wotherspoon, Kyriakos Kouvelakis, Rosalind J. Cutts
Publikováno v:
European Journal of Cancer. 122:12-21
The MYC proto-oncogene is among the most commonly dysregulated genes in human cancers. We report screening data from the iMYC trial, an ongoing phase II study assessing ibrutinib monotherapy in advanced pretreated MYC- and/or HER2-amplified oesophago
Autor:
Marta J. Llorca-Cardenosa, Lauren I. Aronson, Dragomir B. Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T. Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros Roumeliotis, Jyoti Choudhary, Stephen J. Pettitt, Johann de Bono, Andres Cervantes, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Irene Y. Chong
Publikováno v:
CANCER RESEARCH
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Gastric cancer represents the third leading cause of global cancer mortality and an area of unmet clinical need. Drugs that target the DNA damage response, including ATR inhibitors (ATRi), have been proposed as novel targeted agents in gastric cancer
Autor:
Fabio Mirabella, Alexander Murison, Lauren I Aronson, Christopher P Wardell, Andrew J Thompson, Sarah J Hanrahan, Jacqueline H L Fok, Charlotte Pawlyn, Martin F Kaiser, Brian A Walker, Faith E Davies, Gareth J Morgan
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99493 (2014)
The chromosomal translocation t(4;14) deregulates MMSET (WHSC1/NSD2) expression and is a poor prognostic factor in multiple myeloma (MM). MMSET encodes two major protein isoforms. We have characterized the role of the shorter isoform (REIIBP) in myel
Externí odkaz:
https://doaj.org/article/800512e40ad7484aa213d1a499a54ad7
Autor:
Christopher J. Lord, Syed Haider, Ioannis Assiotis, Irene Chong, Ruwaida Begum, Naureen Starling, Nik Matthews, Asif Chaudry, Marta Llorca-Cardenosa, David Watkins, Monica Terlizzo, Andrew Wotherspoon, Ian Chau, Lauren I. Aronson, Alistair G. Rust, Ritika Chauhan, Sheela Rao, John Alexander, David Cunningham, Kerry Fenwick, Sacheen Kumar
Publikováno v:
Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 10, Iss 215, p 215 (2021)
Journal of Clinical Medicine, Vol 10, Iss 215, p 215 (2021)
1. Background: The application of massively parallel sequencing has led to the identification of aberrant druggable pathways and somatic mutations within therapeutically relevant genes in gastro-oesophageal cancer. Given the widespread use of formali
Autor:
Faith E. Davies, Leon Hooftman, Brian A Walker, Lauren I. Aronson, David Krige, Lei Zhang, Emma L. Davenport, Gareth J. Morgan, Alan Hastings Drummond, Emma M. Smith
Publikováno v:
Oncotarget
// Emma M. Smith 1 , Lei Zhang 1 , Brian A. Walker 1 , Emma L. Davenport 1 , Lauren I. Aronson 1 , David Krige 2 , Leon Hooftman 2 , Alan H. Drummond 2 , Gareth J. Morgan 1 and Faith E. Davies 1 1 Haemato-Oncology Research Unit, Division of Molecular
Publikováno v:
Leukemia
Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application