Zobrazeno 1 - 1
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pro vyhledávání: '"Lauren Goeser"'
Autor:
Daniel J. Burdick, Lauren Goeser, Jianping Yin, Shumei Wang, John Moffat, Steven Magnuson, Weiru Wang, Jeff Blaney, Huifen Chen, Borlan Pan, Christopher E. Heise, Jake Drummond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4728-4732
A fragment-based lead discovery approach was used to discover novel ERK2 inhibitors. The crystal structure of N-benzyl-9H-purin-6-amine 1 in complex with ERK2 elucidated its hinge-binding mode. In addition, the simultaneous binding of an imidazole mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b6f6662d3adf70ddbff4a85969d128
https://doi.org/10.1016/j.bmcl.2015.08.048
https://doi.org/10.1016/j.bmcl.2015.08.048
