Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lauren G. Holden"'
Autor:
Rajesh Kumar, Suprit Deshpande, Leigh M Sewall, Gabriel Ozorowski, Christopher A Cottrell, Wen-Hsin Lee, Lauren G Holden, Sara T Richey, Antra Singh Chandrawacar, Kanika Dhiman, Ashish, Vivek Kumar, Shubbir Ahmed, Nitin Hingankar, Naresh Kumar, Kailapuri G Murugavel, Aylur K Srikrishnan, Devin Sok, Andrew B Ward, Jayanta Bhattacharya
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1008977 (2021)
Evaluating the structure-function relationship of viral envelope (Env) evolution and the development of broadly cross-neutralizing antibodies (bnAbs) in natural infection can inform rational immunogen design. In the present study, we examined the mag
Externí odkaz:
https://doaj.org/article/5c0bde4098d240bfabd6e084c96ccc53
Autor:
Tony Ngo, Bryan S Stephens, Martin Gustavsson, Lauren G Holden, Ruben Abagyan, Tracy M Handel, Irina Kufareva
Publikováno v:
PLoS Biology, Vol 18, Iss 4, p e3000656 (2020)
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the
Externí odkaz:
https://doaj.org/article/d76fb27ba6414350aa8acc676fb407bc
Autor:
Jayanta Bhattacharya, Suprit Deshpande, Nitin Hingankar, Sara T. Richey, Vivek Kumar, Ashish, Christopher A. Cottrell, Devin Sok, Kailapuri G. Murugavel, Gabriel Ozorowski, Wen-Hsin Lee, Naresh Kumar, Shubbir Ahmed, Kanika Dhiman, Antra Singh Chandrawacar, Rajesh Kumar, L.M. Sewall, Andrew B. Ward, Lauren G. Holden, Aylur K. Srikrishnan
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 4, p e1008977 (2021)
PLoS Pathogens, Vol 17, Iss 4, p e1008977 (2021)
Evaluating the structure-function relationship of viral envelope (Env) evolution and the development of broadly cross-neutralizing antibodies (bnAbs) in natural infection can inform rational immunogen design. In the present study, we examined the mag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754343c6c5a22b1053d7649b75cdb960
https://pubmed.ncbi.nlm.nih.gov/33826683
https://pubmed.ncbi.nlm.nih.gov/33826683
Autor:
Irina Kufareva, Tony Ngo, Bryan S. Stephens, Martin Gustavsson, Ruben Abagyan, Tracy M. Handel, Lauren G. Holden
Publikováno v:
PLoS Biology, Vol 18, Iss 4, p e3000656 (2020)
PLoS Biology
PLoS biology, vol 18, iss 4
PLoS Biology
PLoS biology, vol 18, iss 4
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ed5821969cb088d818ee8b8ed30653
https://doaj.org/article/d76fb27ba6414350aa8acc676fb407bc
https://doaj.org/article/d76fb27ba6414350aa8acc676fb407bc
Autor:
Vadim Cherezov, Ruben Abagyan, Irina Kufareva, Genevieve Baker, Raymond C. Stevens, Tony Ngo, Martin Gustavsson, Bryan S. Stephens, Lauren G. Holden, Tracy M. Handel, Yi Zheng
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc83006e33bf4217f22050ea37774092
https://doi.org/10.1096/fasebj.2018.32.1_supplement.382.3
https://doi.org/10.1096/fasebj.2018.32.1_supplement.382.3
Autor:
Christopher A. Cottrell, Michael Golabek, Andrew B. Ward, Lauren G. Holden, Anila Yasmeen, Ian A. Wilson, Gabriel Ozorowski, Victor M. Cruz Portillo, Rajesh P. Ringe, Albert Cupo, Pavel Pugach, John P. Moore, Per Johan Klasse, Rogier W. Sanders, Kimmo Rantalainen
Publikováno v:
Journal of virology, 91(12), UNSP e00264-17. American Society for Microbiology
Soluble, recombinant native-like envelope glycoprotein (Env) trimers of various human immunodeficiency virus type 1 (HIV-1) genotypes are being developed for structural studies and as vaccine candidates aimed at the induction of broadly neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb2f8018975e195e4e9fd0b2462009b
https://doi.org/10.1128/jvi.00264-17
https://doi.org/10.1128/jvi.00264-17
Publikováno v:
Methods in enzymology. 570
Despite the recent breakthrough advances in GPCR crystallography, structure determination of protein-protein complexes involving chemokine receptors and their endogenous chemokine ligands remains challenging. Here we describe disulfide trapping, a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a64b5779c51e3c8d1cc347062dcd754
https://pubmed.ncbi.nlm.nih.gov/26921956
https://pubmed.ncbi.nlm.nih.gov/26921956
Despite the recent breakthrough advances in GPCR crystallography, structure determination of protein-protein complexes involving chemokine receptors and their endogenous chemokine ligands remains challenging. Here, we describe disulfide trapping, a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcea6babf1ca037d8fe646a9e7f9ab94
https://doi.org/10.1016/bs.mie.2015.12.001
https://doi.org/10.1016/bs.mie.2015.12.001
Autor:
Michael G. Klein, Yi Zhang, Ganggang Wang, Xiaojiang S. Chen, Lauren G. Holden, Etienne Tokonzaba
Publikováno v:
Nature Structural & Molecular Biology. 15:94-100
Helicases are essential enzymes for DNA replication, a fundamental process in all living organisms. The DnaB family are hexameric replicative helicases that unwind duplex DNA and coordinate with RNA primase and other proteins at the replication fork
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39c75f6137edc6443a442a60f09bea87
https://doi.org/10.1038/nsmb1356
https://doi.org/10.1038/nsmb1356
Autor:
Vadim Cherezov, Gye Won Han, Chong Wang, Raymond C. Stevens, Tracy M. Handel, Yi Zheng, Gustavo Fenalti, Chunxia Zhao, Ling Qin, Lauren G. Holden, Huixian Wu, Ruben Abagyan, Irina Kufareva
Publikováno v:
Science (New York, N.Y.). 347(6226)
Molecular “go” signals reveal their secrets Chemokines are proteins that direct how cells move within the body. For instance, chemokines help immune cells locate invading pathogens and ensure that cells position themselves correctly within a deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94e4e4f9846db54f6fb458a9c78bf7e
https://pubmed.ncbi.nlm.nih.gov/25745149
https://pubmed.ncbi.nlm.nih.gov/25745149