Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lauren G. Friedman"'
Autor:
Roxana E. Mesías, Yosif Zaki, Christopher A. Guevara, Lauren G. Friedman, Ayan Hussein, Karen Therrien, Alexandra R. Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G. Baxter, George W. Huntley, Deanna L. Benson
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108002- (2023)
Summary: Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the postnatally developi
Externí odkaz:
https://doaj.org/article/09770c6bebdf46609f5a2a241cfb54ff
Autor:
Roxana E. Mesías, Yosif Zaki, Christopher A. Guevara, Lauren G. Friedman, Ayan Hussein, Karen Therrien, Alexandra R. Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G. Baxter, George W. Huntley, Deanna L. Benson
Publikováno v:
bioRxiv
SummaryRational decision making is grounded in learning to associate actions with outcomes, a process that depends on projections from prefrontal cortex to dorsomedial striatum. Symptoms associated with a variety of human pathological conditions rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec7aef0d88a21300213a857555ecf07
https://doi.org/10.1101/2023.03.14.532475
https://doi.org/10.1101/2023.03.14.532475
Autor:
Wendy Weidner, Maï Panchal, Linda Thienpont, Howard Fillit, Geraldine Drexel De Buchy, Jakub Hort, Philippe Amouyel, Rosa M. Sancho, Richard Oakley, Sharyn L Rossi, Andrew S. Murtishaw, Heather M. Snyder, Emily A Meyers, Gregor Henderson-Begg, Magali Dumont, Maria C. Carrillo, Lauren G. Friedman, Diane E. Bovenkamp
Publikováno v:
Alzheimer's & Dementia
The COVID‐19 pandemic has disproportionately affected more vulnerable populations, including those living with dementia. Over 50 million individuals worldwide are living with Alzheimer's disease (AD) or other dementia, and it is crucial to continue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38eb283355941b7dbba3d1af91f0ffdc
https://doi.org/10.1002/alz.12472
https://doi.org/10.1002/alz.12472
Autor:
Howard Fillit, Meriel Owen, Elizabeth Finger, Yuko Hara, Susan Dickinson, Nicholas McKeehan, Samuel P. Dickson, Lon S. Schneider, Howard Feldman, Michael Grundman, Judith Jaeger, Melanie Quintana, Jian Zhu, Jeffrey L. Cummings, Deli Wang, Debra Niehoff, J. Michael Ryan, Alessio Travaglia, Richard C. Mohs, Dawn C. Matthews, Jessica T. Markowitz, Lauren G. Friedman, Suzanne Hendrix
Publikováno v:
Neurology, vol 96, iss 20
Neurology
article-version (Version of Record) 3
Neurology
article-version (Version of Record) 3
Drug development for Alzheimer disease and other neurodegenerative dementias, including frontotemporal dementia, has experienced a long history of phase 2 and phase 3 clinical trials that failed to show efficacy of investigational drugs. Despite diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6482189aa8b99725a2bae96520a4c778
https://escholarship.org/uc/item/7cg5f1h9
https://escholarship.org/uc/item/7cg5f1h9
Autor:
Simon H. Ridley, Diana W Shineman, Rosa M. Sancho, Ian Le Guillou, Ara S. Khachaturian, James Pickett, Lauren G. Friedman, Lorenzo M. Refolo, Heather M. Snyder, James Hendrix
Publikováno v:
Alzheimer's & Dementia. 12:1177-1185
The reproducibility of laboratory experiments is fundamental to the scientific process. There have been increasing reports regarding challenges in reproducing and translating preclinical experiments in animal models. In Alzheimer's disease and relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9af794c845957aebd8d8630990c0cc
https://doi.org/10.1016/j.jalz.2016.07.001
https://doi.org/10.1016/j.jalz.2016.07.001
Publikováno v:
Neurotherapeutics. 12:94-108
Many neurodegenerative disorders are characterized by the aberrant accumulation of aggregate-prone proteins. Alzheimer's disease (AD) is associated with the buildup of β-amyloid peptides and tau, which aggregate into extracellular plaques and neurof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4ae275df5557ec8226398dfd9175b7
https://doi.org/10.1007/s13311-014-0320-z
https://doi.org/10.1007/s13311-014-0320-z
Autor:
Lauren G. Friedman, Josefa M. Sullivan, Roxana Mesias, Deanna L. Benson, Frances M. Williams, George W. Huntley, Fréderike W. Riemslagh
Publikováno v:
Journal of Comparative Neurology. 523:75-92
Neocortical interactions with the dorsal striatum support many motor and executive functions, and such underlying functional networks are particularly vulnerable to a variety of developmental, neurological, and psychiatric brain disorders, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81aea3246de16413f889f1ef7caa28c8
https://doi.org/10.1002/cne.23666
https://doi.org/10.1002/cne.23666
Autor:
M. L. Lachenmayer, Zhenyu Yue, L. He, Shibu M. Poulose, Lauren G. Friedman, Jing Wang, G. R. Holstein, Masaaki Komatsu
Publikováno v:
The Journal of Neuroscience. 32:7585-7593
Parkinson's disease (PD) is characterized pathologically by the formation of ubiquitin and α-synuclein (α-syn)-containing inclusions (Lewy bodies), dystrophic dopamine (DA) terminals, and degeneration of midbrain DA neurons. The precise molecular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8806edb3f88731bd06704e043099be89
https://doi.org/10.1523/jneurosci.5809-11.2012
https://doi.org/10.1523/jneurosci.5809-11.2012
Publikováno v:
Current topics in developmental biology. 112
It is tacitly understood that cell adhesion molecules (CAMs) are critically important for the development of cells, circuits, and synapses in the brain. What is less clear is what CAMs continue to contribute to brain structure and function after the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae55eb4d52425646f5285ca8848decf
https://pubmed.ncbi.nlm.nih.gov/25733148
https://pubmed.ncbi.nlm.nih.gov/25733148