Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Lauren G. Douma"'
Autor:
Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann Pham, Aline C. Oliveira, Chunhua Fu, Amy Nguyen, Bryan R. Alava, Stuart J. Hesketh, Andrew R. Morris, Mehari M. Endale, G. Ryan Crislip, Kit-yan Cheng, Elizabeth A. Schroder, Brian P. Delisle, Andrew J. Bryant, Michelle L. Gumz, Zhiguang Huo, Andrew C. Liu, Karyn A. Esser
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111982- (2023)
Summary: Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level
Externí odkaz:
https://doaj.org/article/2f18b4dcc2854c8b81ce1f23e09506dc
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
The reality of life in modern times is that our internal circadian rhythms are often out of alignment with the light/dark cycle of the external environment. This is known as circadian disruption, and a wealth of epidemiological evidence shows that it
Externí odkaz:
https://doaj.org/article/37b907a25de44c2b8424584eb170eabb
Autor:
Lauren G. Douma, Kristen Solocinski, Sarah H. Masten, Dominique H. Barral, Sarah J. Barilovits, Lauren A. Jeffers, Kareme D. Alder, Ravi Patel, Charles S. Wingo, Kevin D. Brown, Brian D. Cain, Michelle L. Gumz
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Endothelin-1 (ET-1) is a peptide hormone that functions as a vasoconstrictor in the vasculature, whereas in the collecting duct of the kidney it exerts blood pressure-lowering effects via natriuretic actions. Aberrant ET-1 signaling is associated wit
Externí odkaz:
https://doaj.org/article/d38dc8aced764e8586b852892c45a7a2
Autor:
Adrian Zietara, Denisha R. Spires, Alexandria Juffre, Hannah M. Costello, G. Ryan Crislip, Lauren G. Douma, Vladislav Levchenko, Lashodya V. Dissanayake, Christine A. Klemens, Oksana Nikolaienko, Aron M. Geurts, Michelle L. Gumz, Alexander Staruschenko
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(11)
Background: Circadian rhythms play an essential role in physiological function. The molecular clock that underlies circadian physiological function consists of a core group of transcription factors, including the protein PER1 (Period1). Studies in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7209767218d6667cfb7765fd7380930
https://pubmed.ncbi.nlm.nih.gov/36093781
https://pubmed.ncbi.nlm.nih.gov/36093781
Publikováno v:
Nucleic Acids Research. 50:12872-12884
Single-stranded DNA binding proteins (SSBs) avidly bind ssDNA and yet enzymes that need to act during DNA replication and repair are not generally impeded by SSB, and are often stimulated by SSB. Here, the effects of Escherichia coli SSB on the activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1356a33edc2d1459e50766de66855e71
https://doi.org/10.1093/nar/gkac1169
https://doi.org/10.1093/nar/gkac1169
Autor:
Hannah M Costello, G Ryan Crislip, Kit-Yan Cheng, I Jeanette Lynch, Alexandria Juffre, Phillip Bratanatawira, Annalisse Mckee, Ryanne S Thelwell, Victor M Mendez, Charles S Wingo, Lauren G Douma, Michelle L Gumz
Publikováno v:
Function. 4
Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription factor that regulates many physiological functions, including blood pressure (BP). Male global Bmal1 knockout (KO) mice exhibit ∼10 mmHg reduction in BP, as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2348ff19c69120aa78b2ae811147322c
https://doi.org/10.1093/function/zqad001
https://doi.org/10.1093/function/zqad001
Autor:
G. Ryan Crislip, Jermaine G. Johnston, Lauren G. Douma, Hannah M. Costello, Alexandria Juffre, Kyla Boyd, Wendy Li, Cheoting C. Maugans, Miguel Gutierrez‐Monreal, Karyn A. Esser, Andrew J. Bryant, Andrew C. Liu, Michelle L. Gumz
Publikováno v:
Comprehensive Physiology. :2769-2798
Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4537d5957dcfab201f4f2306a4116945
https://doi.org/10.1002/cphy.c210011
https://doi.org/10.1002/cphy.c210011
Autor:
Hannah M. Costello, Alexandria Juffre, Kit-Yan Cheng, Phillip Bratanatawira, G. Ryan Crislip, Adrian Zietara, Denisha R. Spires, Alexander Staruschenko, Lauren G. Douma, Michelle L. Gumz
Publikováno v:
Canadian journal of physiology and pharmacology.
Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated with various diseases, including salt-sensitive hypertension and chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f64c6ac17854d0ebbfbe8a1897b52a
https://pubmed.ncbi.nlm.nih.gov/36450128
https://pubmed.ncbi.nlm.nih.gov/36450128
Publikováno v:
Physiology (Bethesda)
The peptide hormone endothelin-1 and its receptors are linked to several disease states. Pharmacological inhibition of this pathway has proven beneficial in pulmonary hypertension, yet its potential in other disease states remains to be realized. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4a03ba972397dc60adb04464aa110f
https://doi.org/10.1152/physiol.00021.2020
https://doi.org/10.1152/physiol.00021.2020
Publikováno v:
Biophys J
Sliding clamps are oligomeric ring-shaped proteins that increase the efficiency of DNA replication. The stability of the Escherichia coli β-clamp, a homodimer, is particularly remarkable. The dissociation equilibrium constant of the β-clamp is of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52881ba217871af563f82690aed3f78
https://doi.org/10.1016/j.bpj.2020.11.013
https://doi.org/10.1016/j.bpj.2020.11.013