Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lauren F. Barnes"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 327-336 (2022)
Charge detection mass spectrometry (CDMS) was used to analyze recombinant adeno-associated virus serotype 8 (rAAV8) vectors after incubation at elevated temperatures. rAAV8 vectors with a range of genomes of interest (GOIs) from 2.22 to 4.84 kb were
Externí odkaz:
https://doaj.org/article/3c212eaa5b8041f5a4fd01b527ebcdb2
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 87-97 (2021)
Recombinant adeno-associated virus (rAAV) has emerged as an important gene therapy vector with many clinical trials currently in progress. Analytical characterization and quantitation of particle content remain challenges in both the development and
Externí odkaz:
https://doaj.org/article/28f9114c8b014b91af5eaa66b9638873
Autor:
Elise K. Mullins, Thomas W. Powers, Jim Zobel, Kory M. Clawson, Lauren F. Barnes, Benjamin E. Draper, Qin Zou, Joseph J. Binder, Stanley Dai, Kun Zhang, Olga Friese, Herbert A. Runnels, Martin F. Jarrold, Lawrence C. Thompson
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
We observed differential infectivity and product yield between two recombinant chimpanzee adenovirus C68 constructs whose primary difference was genome length. To determine a possible reason for this outcome, we characterized the proportion and compo
Externí odkaz:
https://doaj.org/article/f1f1e75dde024640af7aecb78aac433e
Autor:
Brianna M. Woodbury, Tina Motwani, Makayla N. Leroux, Lauren F. Barnes, Nicholas A. Lyktey, Sanchari Banerjee, Corynne L. Dedeo, Martin F. Jarrold, Carolyn M. Teschke
Publikováno v:
Viruses, Vol 14, Iss 7, p 1400 (2022)
The oligomerization and incorporation of the bacteriophage P22 portal protein complex into procapsids (PCs) depends upon an interaction with scaffolding protein, but the region of the portal protein that interacts with scaffolding protein has not bee
Externí odkaz:
https://doaj.org/article/e9045634e7dd4872a8e106b9a7a8c50f
Autor:
Lauren F. Barnes, Benjamin E. Draper, Justin Kurian, Yu-Ting Chen, Tatiana Shapkina, Thomas W. Powers, Martin F. Jarrold
Publikováno v:
Analytical Chemistry. 95:4310-4316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63707cf57fab0403804fdb73d6cd7f53
https://doi.org/10.1021/acs.analchem.2c04234
https://doi.org/10.1021/acs.analchem.2c04234
Publikováno v:
Biochemistry. 61:505-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d078cd7d17b4620b209d669e06040a4b
https://doi.org/10.1021/acs.biochem.1c00810
https://doi.org/10.1021/acs.biochem.1c00810
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 87-97 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 87-97 (2021)
Recombinant adeno-associated virus (rAAV) has emerged as an important gene therapy vector with many clinical trials currently in progress. Analytical characterization and quantitation of particle content remain challenges in both the development and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f85cfd88528efcdb9b7abb7e517866c
https://doi.org/10.1016/j.omtm.2021.08.002
https://doi.org/10.1016/j.omtm.2021.08.002
Autor:
Jonathan C. Trinidad, Xuyao Zeng, Brooke A. Brown, Lauren F. Barnes, Jonathan M. A. Winstone, David E. Clemmer, Aaron R. Todd, Martin F. Jarrold, Milos V. Novotny
Publikováno v:
Anal Chem
The masses of particles in a bovine milk extracellular vesicle (EV) preparation enriched for exosomes were directly determined for the first time by charge detection mass spectrometry (CDMS). In CDMS, both the mass-to-charge ratio (m/z) and z are det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4093e0d1d59f649754541fe701cba2
https://doi.org/10.1021/acs.analchem.9b05173
https://doi.org/10.1021/acs.analchem.9b05173
Autor:
Brian Bothner, Adam Zlotnick, Christine Kim, Christopher John Schlicksup, Che-Yen Joseph Wang, Angela Patterson, Lauren F. Barnes, Martin F. Jarrold
Publikováno v:
J Virol
Viral structural proteins can have multiple activities. Antivirals that target structural proteins have potential to exhibit multiple antiviral mechanisms. Hepatitis B virus (HBV) core protein (Cp) is involved in most stages of the viral life cycle;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247950fe3908957bd7fd2ae3e2e1571e
https://europepmc.org/articles/PMC8791275/
https://europepmc.org/articles/PMC8791275/
Publikováno v:
Analytical chemistry. 94(3)
Adenovirus is one of the largest nonenveloped, double-stranded DNA viruses. It is widely used as a gene therapy vector and has recently received a lot of attention as a novel vaccine platform for SARS-CoV-2. Human adenovirus 5 (HAdV5) contains over 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6cf975425999fb010b161206784391
https://pubmed.ncbi.nlm.nih.gov/35023731
https://pubmed.ncbi.nlm.nih.gov/35023731