Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lauren F, Sestito"'
Autor:
Jihoon Kim, David M. Francis, Lauren F. Sestito, Paul A. Archer, Margaret P. Manspeaker, Meghan J. O’Melia, Susan N. Thomas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nitric oxide exerts a multitude of physiological functions and has also been exploited for anticancer therapies. Here the authors report the design of a micelle-releasing thermosensitive hydrogel system for the concomitant locoregional and lymphatic
Externí odkaz:
https://doaj.org/article/955df8be82f34fec86bf0913efa76330
Autor:
Camila P. Camargo, Abir K. Muhuri, Yunus Alapan, Lauren F. Sestito, Megha Khosla, Margaret P. Manspeaker, Aubrey S. Smith, Chrystal M. Paulos, Susan N. Thomas
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112175- (2023)
Summary: CD8+ T cell recruitment to the tumor microenvironment is critical for the success of adoptive cell therapy (ACT). Unfortunately, only a small fraction of transferred cells home to solid tumors. Adhesive ligand-receptor interactions have been
Externí odkaz:
https://doaj.org/article/b4f20bae16a84fccbccc5487a170cc42
Autor:
Lauren F. Sestito, Kim H. T. To, Matthew T. Cribb, Paul A. Archer, Susan N. Thomas, J. Brandon Dixon
Publikováno v:
Science Advances. 9
Dysfunction of collecting lymphatic vessel pumping is associated with an array of pathologies. S-(−)-Bay K8644 (BayK), a small-molecule agonist of L-type calcium channels, improves vessel contractility ex vivo but has been left unexplored in vivo b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::613f5662b59b57b499ee854a44838710
https://doi.org/10.1126/sciadv.abq0435
https://doi.org/10.1126/sciadv.abq0435
Autor:
Lauren F. Sestito, Susan N. Thomas, Nathan A. Rohner, Meghan J. O'Melia, Yajun Mei, Alex Schudel, Margaret P. Manspeaker, Paul A. Archer
Publikováno v:
Drug Deliv Transl Res
Lymph nodes (LNs) are tissues of the immune system that house leukocytes, making them targets of interest for a variety of therapeutic immunomodulation applications. However, achieving accumulation of a therapeutic in the LN does not guarantee equal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad01c45b4430c866126119b1fedd8de
https://pubmed.ncbi.nlm.nih.gov/34165731
https://pubmed.ncbi.nlm.nih.gov/34165731
Autor:
Jihoon, Kim, David M, Francis, Lauren F, Sestito, Paul A, Archer, Margaret P, Manspeaker, Meghan J, O'Melia, Susan N, Thomas
Publikováno v:
Nature communications. 13(1)
Due to their autosynchronous roles in shaping the anti-tumor immune response, complex immune regulatory networks acting both locally within the tumor microenvironment as well as in its draining lymph nodes play critical roles in the cancer immunother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fd45e0e77a993d3b06b6e8dc9c41318
https://pubmed.ncbi.nlm.nih.gov/35304456
https://pubmed.ncbi.nlm.nih.gov/35304456
Autor:
Alexander J. Heiler, Alex Schudel, Margaret P. Manspeaker, David M. Francis, Paul A. Archer, Lauren F. Sestito, Susan N. Thomas
Publikováno v:
Biomaterials
Multiple small molecule immune modulators have been identified as synergistic with immune checkpoint blockade (ICB) in their effects on T lymphocytes , but are limited in their successful application to combination cancer immunotherapy due to their s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f6b0cd5df1468c953ae7a176c93b4d
https://pubmed.ncbi.nlm.nih.gov/34678650
https://pubmed.ncbi.nlm.nih.gov/34678650
Autor:
Meghan J. O'Melia, Edmund K. Waller, Brian Pollack, Alex Schudel, David M. Francis, Margaret P. Manspeaker, Haydn T. Kissick, Susan N. Thomas, Lauren F. Sestito
Publikováno v:
Science translational medicine
Systemic administration of immune checkpoint blockade (ICB) monoclonal antibodies (mAbs) can unleash antitumor functions of T cells but is associated with variable response rates and off-target toxicities. We hypothesized that antitumor efficacy of I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a8d52f1dbfbee28c10fab4e528194a
https://doi.org/10.1126/scitranslmed.aay3575
https://doi.org/10.1126/scitranslmed.aay3575
Autor:
Susan N. Thomas, Lauren F. Sestito
Publikováno v:
Biomaterials
Lymph nodes (LNs) are immune organs housing high concentrations of lymphocytes, making them critical targets for therapeutic immunomodulation in a wide variety of diseases. While there is great interest in targeted drug delivery to LNs, many nanoscal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61acefb7793c953a1508c795c30090b2
https://pubmed.ncbi.nlm.nih.gov/33080460
https://pubmed.ncbi.nlm.nih.gov/33080460
Publikováno v:
Journal of Biomedical Materials Research Part A. 106:1463-1475
Nitric oxide (NO) is a therapeutic implicated for the treatment of diseases afflicting lymphatic tissues, which range from infectious and cardiovascular diseases to cancer. Existing technologies available for NO therapy, however, provide poor bioacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ac1a6f8076788d4bd5b1dc98789c7e
https://doi.org/10.1002/jbm.a.36348
https://doi.org/10.1002/jbm.a.36348
Autor:
Lauren F. Sestito, Susan N. Thomas
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Immunoengineering is a rapidly growing and interdisciplinary field focused on developing tools to study and understand the immune system, then employing that knowledge to modulate immune response for the treatment of disease. Becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c889fef7853de56fc846960771da8b
https://pubmed.ncbi.nlm.nih.gov/32259064
https://pubmed.ncbi.nlm.nih.gov/32259064