Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lauren E. Stopfer"'
Autor:
Lauren E. Stopfer, Joshua M. Mesfin, Brian A. Joughin, Douglas A. Lauffenburger, Forest M. White
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Immunopeptidomics allows identifying the cellular repertoire of MHC-bound peptides, but quantifying them remains challenging. Here, the authors present a method to efficiently generate internal peptide MHC standards and calibration curves, facilitati
Externí odkaz:
https://doaj.org/article/a31704ed76cf4812b9becfece7121839
Autor:
Stefani Spranger, Fiona Chatterjee, Esmee P Hoefsmit, Tim B Fessenden, Lauren E Stopfer, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Christian Blank, Forest White
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background For effective tumor elimination, cytotoxic CD8+ T cells must recognize tumor-derived antigens presented on class I major histocompatibility complex (MHC-I). Despite a general association between the expression of immunogenic antigens, typi
Externí odkaz:
https://doaj.org/article/6e47349a08334a24aaee85b7133f5532
Autor:
Forest M. White, Daniel Lopez-Ferrer, Sebastien Gallien, Bhavin Patel, Aaron S. Gajadhar, Cameron T. Flower, Lauren E. Stopfer
Custom pathway and substrate-kinase libraries for tumor-specific pathway enrichment analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af399a7c61d5eadc3e2ce7d0796d6de
https://doi.org/10.1158/0008-5472.22428637
https://doi.org/10.1158/0008-5472.22428637
Autor:
Forest M. White, Daniel Lopez-Ferrer, Sebastien Gallien, Bhavin Patel, Aaron S. Gajadhar, Cameron T. Flower, Lauren E. Stopfer
Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels may reveal therapeutic insights critical to combating disease. Existing discovery and targete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a48dc30bd55985ed74c8f107a74e8fc
https://doi.org/10.1158/0008-5472.c.6513085.v1
https://doi.org/10.1158/0008-5472.c.6513085.v1
Autor:
Forest M. White, Daniel Lopez-Ferrer, Sebastien Gallien, Bhavin Patel, Aaron S. Gajadhar, Cameron T. Flower, Lauren E. Stopfer
Supplementary figures, table legends, and methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fafc5e9ab393a1a3f009985ef784041
https://doi.org/10.1158/0008-5472.22428643
https://doi.org/10.1158/0008-5472.22428643
Autor:
Lauren E. Stopfer, Nicholas J. Rettko, Owen Leddy, Joshua M. Mesfin, Eric Brown, Shannon Winski, Bryan Bryson, James A. Wells, Forest M. White
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 49
Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma – namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies – may offer an improved survival benefit by overcoming limitations associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507575a58c1c839faffea542a485bc14
https://doi.org/10.1073/pnas.2208900119
https://doi.org/10.1073/pnas.2208900119
Autor:
Alex M. Jaeger, Lauren E. Stopfer, Ryuhjin Ahn, Emma A. Sanders, Demi A. Sandel, William A. Freed-Pastor, William M. Rideout, Santiago Naranjo, Tim Fessenden, Kim B. Nguyen, Peter S. Winter, Ryan E. Kohn, Peter M. K. Westcott, Jason M. Schenkel, Sean-Luc Shanahan, Alex K. Shalek, Stefani Spranger, Forest M. White, Tyler Jacks
Publikováno v:
Nature
Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I)(1,2,3,4,5). Current approaches to profile MHC-I associated peptides, collectively known as the “immunopeptidome”, are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c592d9e991788f10c2d2d6252e7d29e
https://europepmc.org/articles/PMC9945857/
https://europepmc.org/articles/PMC9945857/
Autor:
Bhavin Patel, Aaron S. Gajadhar, Forest M. White, Genevieve M. Boland, Lauren E. Stopfer, Ryan J. Sullivan, Dennie T. Frederick, Sebastien Gallien
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Absolute quantification measurements (copies per cell) of peptide major histocompatibility complex (pMHC) antigens are necessary to inform targeted immunotherapy drug design; however, existing methods for absolute quantification have critical limitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8007f4056d7a03d833b691d38fb8edb1
https://doi.org/10.1073/pnas.2111173118
https://doi.org/10.1073/pnas.2111173118
Autor:
Alex K. Shalek, Kohn R, Forest M. White, Santiago Naranjo, William M. Rideout, Alex M. Jaeger, Demi Sandel, Tim B. Fessenden, Shanahan S, Tyler Jacks, Sanders E, Jason M. Schenkel, William A. Freed-Pastor, Winter Ps, Lauren E. Stopfer, Stefani Spranger
Effective immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex Class I (MHC-I). Recent developments in proteomics have improved the identification of peptides that are naturally presented by M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe4dd68f5179f45d41273fa6d4792588
https://doi.org/10.1101/2021.06.30.450516
https://doi.org/10.1101/2021.06.30.450516
Autor:
Alex M. Jaeger, Forest M. White, Sunmin Lee, Tyler Jacks, Lauren E. Stopfer, Susan Lindquist, Demi Sandel, Luke Whitesell, Giorgio Gaglia, Nan Lin, Jane B. Trepel, Sandro Santagata
Publikováno v:
PMC
Clin Cancer Res
Clin Cancer Res
Purpose: Despite the accumulation of extensive genomic alterations, many cancers fail to be recognized as "foreign" and escape destruction by the host immune system. Immunotherapies designed to address this problem by directly stimulating immune effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dc5bd90ff4c9cccaf80a2a86067f2b
https://doi.org/10.1158/1078-0432.ccr-19-0596
https://doi.org/10.1158/1078-0432.ccr-19-0596