Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lauren E. Oleson"'
Autor:
Christine Wanke, David J. Greenblatt, Tamsin A. Knox, Rhonda C Kaufman, Lauren E. Oleson, Lisa L. von Moltke
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 49:358-368
PURPOSE Ritonavir is a powerful inhibitor of cytochrome P450 3A (CYP3A) that metabolizes many antiretrovirals. We examined the effect of ritonavir and of chronic viral hepatitis (CVH) status on CYP3A activity. METHODS Twenty-six HIV-positive men (13
Autor:
Lauren E. Oleson, Michael H. Court
Publikováno v:
Journal of Pharmacy and Pharmacology. 60:1175-1182
Glucuronidation studies using microsomes and recombinant uridine diphosphoglucuronosyltransferases (UGTs) can be complicated by the presence of endogenous β-glucuronidases, leading to underestimation of glucuronide formation rates. Saccharolactone i
Autor:
Jerold S. Harmatz, Yanli Zhao, Lauren E. Oleson, Miguel A. Zinny, Michael H. Court, Dora Farkas, David J. Greenblatt
Publikováno v:
The Journal of Clinical Pharmacology. 47:286-294
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam a
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 40(2)
Single nucleotide polymorphisms in the 3'-untranslated region (3'UTR) of the human pregnane X receptor (PXR) gene might contribute to interindividual variability in cytochrome P450 3A (CYP3A) activity. Genotype-phenotype associations involving PXR-3'
Autor:
Michael H. Court, Jerold S. Harmatz, Noah Berkowitz, Diane E. Peters, Malcolm W. MacNab, Lauren E. Oleson, Miguel A. Zinny, David J. Greenblatt
Publikováno v:
British journal of clinical pharmacology. 68(6)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The viral protease inhibitor ritonavir is known to inhibit clearance of intravenous midazolam. • ALT-2074, a catalytic mimic of glutathione oxidase, inhibits human cytochrome P450 3A (CYP3A) isoforms in