Obesity and Multiple Sclerosis: A Mendelian Randomization Study.

Autor: Lauren E Mokry, Stephanie Ross, Nicholas J Timpson, Stephen Sawcer, George Davey Smith, J Brent Richards

Publikováno v: PLoS Medicine, Vol 13, Iss 6, p e1002053 (2016)

Observational studies have reported an association between obesity, as measured by elevated body mass index (BMI), in early adulthood and risk of multiple sclerosis (MS). However, bias potentially introduced by confounding and reverse causation may h

Externí odkaz: https://doaj.org/article/7c6ff42614194f5f8d3a95e1c86509d5

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.

Autor: Lauren E Mokry, Stephanie Ross, Omar S Ahmad, Vincenzo Forgetta, George Davey Smith, David Goltzman, Aaron Leong, Celia M T Greenwood, George Thanassoulis, J Brent Richards

Publikováno v: PLoS Medicine, Vol 12, Iss 8, p e1001866 (2015)

BackgroundObservational studies have demonstrated an association between decreased vitamin D level and risk of multiple sclerosis (MS); however, it remains unclear whether this relationship is causal. We undertook a Mendelian randomization (MR) study

Externí odkaz: https://doaj.org/article/dbb76c72ea6440ab8494e041a75aac25

Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study

Autor: Luke Devey, Lon R. Cardon, Sirui Zhou, Dawn Waterworth, Cong Guo, George Davey Smith, Robert A. Scott, Claudia Langenberg, Lauren E. Mokry, J. Brent Richards, Philippe Sanseau, Nicholas J. Wareham

Publikováno v: Mokry, L E, Zhou, S, Guo, C, Scott, R A, Devey, L, Langenberg, C, Wareham, N, Waterworth, D M, Cardon, L, Sanseau, P, Davey Smith, G & Richards, B 2019, ' Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease : A Mendelian randomization study ', Scientific Reports, vol. 9, no. 1, 9386 (2019) . https://doi.org/10.1038/s41598-019-45747-2
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)

Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f510183360e555079dd02158bc2a5c4
https://www.repository.cam.ac.uk/handle/1810/307379

Large differences in adiponectin levels have no clear effect on multiple sclerosis risk:A Mendelian randomization study

Autor: Lauren E. Mokry, John A. Morris, Stephen Sawcer, George Davey Smith, J. Brent Richards, Vincenzo Forgetta, Julia Devorak

Publikováno v: Devorak, J, Mokry, L E, Morris, J A, Forgetta, V, Davey Smith, G, Sawcer, S J & Richards, J B 2017, ' Large differences in adiponectin levels have no clear effect on multiple sclerosis risk : A Mendelian randomization study ', Multiple Sclerosis Journal, vol. 23, no. 11, pp. 1461-1468 . https://doi.org/10.1177/1352458516681196

Background: Mendelian randomization (MR) studies have demonstrated strong support for an association between genetically increased body mass index and risk of multiple sclerosis (MS). The adipokine adiponectin may be a potential mechanism linking bod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c09cc767dc7f8d28a53962bdc035206
https://hdl.handle.net/1983/5d5648ae-21fd-464f-a93f-243fb429aa8c

Vitamin D: Ten Beliefs

Autor: J. Brent Richards, Lauren E. Mokry

Publikováno v: Journal of general internal medicine. 31(11)

T o the Editor: The narrative review by Allan and colleagues concluded that while vitamin D supplementation provides some benefit in fracture prevention, it has not been demonstrated to prevent cancer, respiratory tract infections or rheumatoid arthr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9f4c4cb2d43682d0aff9f4f3acc677
https://pubmed.ncbi.nlm.nih.gov/27084755