Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lauren E. Gergel"'
Autor:
Tibor Keler, Henry C. Marsh, Andrea Crocker, Karuna Sundarapandiyan, Jenifer Widger, Russell A. Hammond, Catherine D. Pilsmaker, James R. Storey, James M. Boyer, Eric M. Forsberg, Lauren E. Gergel, Hans Minderman, Paul K. Wallace, Ree Y. Dolnick, Thomas O'Neill, Laura Vitale, Lawrence J. Thomas
Epitope mapping using overlapping TIM-1 fragments. A series of peptides from the amino acid sequence 209-222 of TIM-1 were synthesized and coated to plates to demonstrate direct binding by CDX-014 mAb.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ef2f851dda5b47f9ea601b8b774f8c
https://doi.org/10.1158/1535-7163.22508622.v1
https://doi.org/10.1158/1535-7163.22508622.v1
Autor:
Tibor Keler, Henry C. Marsh, Andrea Crocker, Karuna Sundarapandiyan, Jenifer Widger, Russell A. Hammond, Catherine D. Pilsmaker, James R. Storey, James M. Boyer, Eric M. Forsberg, Lauren E. Gergel, Hans Minderman, Paul K. Wallace, Ree Y. Dolnick, Thomas O'Neill, Laura Vitale, Lawrence J. Thomas
Structure of CDX-014. CDX-014 is a fully human monoclonal antibody specific for TIM-1 covalently linked to the enzyme-cleavable valine-citrulline-p-aminobenzylcarbamate-monomethylauristatin-E (vcMMAE). The drug to antibody (DAR) molar ratio was appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae73207c29191e23654e5d1589c701d
https://doi.org/10.1158/1535-7163.22508625.v1
https://doi.org/10.1158/1535-7163.22508625.v1
Autor:
April R. Baronas, Tibor Keler, Thomas O'Neill, James R. Storey, Crystal Sisson, Joel Goldstein, Lauren E. Gergel, Li-Zhen He, Lawrence J. Thomas, James M. Boyer, Laura Vitale, Karuna Sundarapandiyan, Henry C. Marsh, Andrea Crocker, Eric M. Forsberg, Jeffrey Weidlick, Jenifer Widger
Publikováno v:
Cancer Immunology, Immunotherapy. 68:233-245
Limitations of immunotherapy include poorly functioning events early in the immune response cycle, such as efficient antigen presentation and T cell priming. CD40 signaling in dendritic cells leads to upregulation of cell surface costimulatory and MH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf4ba7c6ef4f74c4b8292604d18745f
https://doi.org/10.1007/s00262-018-2267-0
https://doi.org/10.1007/s00262-018-2267-0
Autor:
Andrea Crocker, Eric M. Forsberg, Hans Minderman, James R. Storey, Thomas O'Neill, Russell A. Hammond, Paul K. Wallace, Lauren E. Gergel, Henry C. Marsh, James M. Boyer, Laura Vitale, Karuna Sundarapandiyan, Jenifer Widger, Catherine D. Pilsmaker, Ree Y. Dolnick, Tibor Keler, Lawrence J. Thomas
Publikováno v:
Molecular Cancer Therapeutics. 15:2946-2954
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a type I transmembrane protein that was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression in kidney and urine after renal injury. TIM-1 expression is also upreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57cc681ca6cfd65c054ddab3cacf8dd
https://doi.org/10.1158/1535-7163.mct-16-0393
https://doi.org/10.1158/1535-7163.mct-16-0393
Autor:
Richard Kang, Henry C. Marsh, Ekambar R. Kandimalla, Lauren E. Gergel, Tibor Keler, Li-Zhen He, Bart R. Anderson, James M. Boyer, Eric M. Forsberg, Kathleen M. Borrelli, Jeffrey Weidlick, Lawrence J. Thomas, Mallary Rocheleau, April R. Baronas, Anna Wasiuk, Subbarao Nallagatla, Elizabeth Q. Do
Publikováno v:
Cancer Research. 79:3217-3217
Recent studies have highlighted the critical role of CD103+/CD141+ dendritic cells (DCs) in antitumor immunity. CDX-301 is a soluble, recombinant human FLT3 ligand (Flt3L). Flt3L is a hematopoietic cytokine which stimulates the proliferation and diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef587a5064c7229202d4137412876fec
https://doi.org/10.1158/1538-7445.am2019-3217
https://doi.org/10.1158/1538-7445.am2019-3217
Autor:
Jeffrey Weidlick, Elizabeth Q. Do, April R. Baronas, James L. Boyer, James Testa, Crystal Sisson, Tibor Keler, Anna Wasiuk, Michelle E. Grealish, Laura Vitale, Henry C. Marsh, Eric Forsberg, Li-Zhen He, Lauren E. Gergel, Lawrence J. Thomas, Thomas O'Neill, Mallary Rocheleau, Kathleen M. Borrelli, Catherine D. Pilsmaker
Publikováno v:
Cancer Research. 78:3816-3816
CD40 on antigen presenting cells plays a critical role in the induction of effective innate and adaptive immune responses. In contrast, CD40 signaling on certain malignant cells, particularly B cell lymphomas, inhibits proliferation or triggers apopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e8cce44e63b20eee0f931934aafc068
https://doi.org/10.1158/1538-7445.am2018-3816
https://doi.org/10.1158/1538-7445.am2018-3816
Autor:
Kathleen M. Borrelli, Nohely Vargas, April Sandland, Catherine D. Pilsmaker, Sarah M. Round, Eric Forsberg, Tibor Keler, Lawrence J. Thomas, Henry C. Marsh, Lauren E. Gergel, James L. Boyer
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9fa14735f708bc9185bbfbb8edc74c8
https://doi.org/10.1096/fasebj.29.1_supplement.945.15
https://doi.org/10.1096/fasebj.29.1_supplement.945.15
Autor:
James M. Boyer, Li-Zhen He, Henry C. Marsh, Anna Wasiuk, Lawrence J. Thomas, Tibor Keler, Sarah M. Round, Lauren E. Gergel
Publikováno v:
Cancer Research. 75:253-253
Varlilumab (CDX-1127) is a fully human agonist antibody to CD27, a TNF receptor superfamily member expressed on the majority of T cells and subsets of NK cells and B cells. As such, varlilumab is an immunotherapy designed to harness the body's natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555db433aa1b995d4944a2ea11f8259c
https://doi.org/10.1158/1538-7445.am2015-253
https://doi.org/10.1158/1538-7445.am2015-253
Autor:
Lawrence J. Thomas, Sarah R. Naylor, Eric Forsberg, James M. Boyer, Sarah M. Round, Tibor Keler, Catherine D. Pilsmaker, Lauren E. Gergel, Kathleen M. Borrelli, Henry C. Marsh
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d67654606d1764239e75b92c8040813
https://doi.org/10.1096/fasebj.27.1_supplement.1103.5
https://doi.org/10.1096/fasebj.27.1_supplement.1103.5
Autor:
Henry C. Marsh, Catherine D. Pilsmaker, Laura Vitale, Tibor Keler, Lauren E. Gergel, Eric M. Forsberg, Lawrence J. Thomas
Publikováno v:
The FASEB Journal. 27
CDX-1135 (sCR1) is a soluble recombinant glycoprotein derived from the human complement regulatory protein Complement Receptor Type 1 (CR1, CD35, C3b/C4b receptor). CDX-1135 inhibits the classical,...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64168e13ed94555499f13176382d7bbb
https://doi.org/10.1096/fasebj.27.1_supplement.lb591
https://doi.org/10.1096/fasebj.27.1_supplement.lb591