Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Lauren E. Brown"'
Autor:
Zihao Wang, Ritesh P. Thakare, Shalaka Chitale, Alok K. Mishra, Stanley I. Goldstein, Alice C. Fan, Rui Li, Lihua Julie Zhu, Lauren E. Brown, Regina Cencic, Sidong Huang, Michael R. Green, Jerry Pelletier, Sunil K. Malonia, John A. Porco
Publikováno v:
ACS Central Science, Vol 10, Iss 8, Pp 1640-1656 (2024)
Externí odkaz:
https://doaj.org/article/3b8ffa6689c34fa3a6cde5b04740c305
Autor:
Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries, Bandana Sharma, Alyssa Kennedy, John A. Porco, Jr., Rani E. George
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114134- (2024)
Summary: Tumor MYCN amplification is seen in high-risk neuroblastoma, yet direct targeting of this oncogenic transcription factor has been challenging. Here, we take advantage of the dependence of MYCN-amplified neuroblastoma cells on increased prote
Externí odkaz:
https://doaj.org/article/c27456a402fc45b2a3efce99ad4f2e45
Autor:
Sara Fallah, Dustin Duncan, Kyle D. Reichl, Michael J. Smith, Wenyu Wang, John A. Porco, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTCandida albicans, one of the most prevalent human fungal pathogens, causes diverse diseases extending from superficial infections to deadly systemic mycoses. Currently, only three major classes of antifungal drugs are available to treat syste
Externí odkaz:
https://doaj.org/article/0310e0d547f54976a2f68da74ed7b338
Autor:
Lee Shaashua, Aviad Ben-Shmuel, Meirav Pevsner-Fischer, Gil Friedman, Oshrat Levi-Galibov, Subhiksha Nandakumar, Debra Barki, Reinat Nevo, Lauren E. Brown, Wenhan Zhang, Yaniv Stein, Chen Lior, Han Sang Kim, Linda Bojmar, William R. Jarnagin, Nicolas Lecomte, Shimrit Mayer, Roni Stok, Hend Bishara, Rawand Hamodi, Ephrat Levy-Lahad, Talia Golan, John A. Porco, Christine A. Iacobuzio-Donahue, Nikolaus Schultz, David A. Tuveson, David Lyden, David Kelsen, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Cancer-associated fibroblasts are transcriptionally rewired by signals from the cancer cells, resulting in heterogeneous populations. Here the authors show that loss of BRCA function in pancreatic cancer cells leads to HSF1–dependent accumulation o
Externí odkaz:
https://doaj.org/article/ace9d26882394fbe81d1eae2056e5de9
Autor:
Gabe H. Miller, Guadalupe Marquez-Velarde, Erika-Danielle Lindstrom, Verna M. Keith, Lauren E. Brown
Publikováno v:
SSM: Population Health, Vol 18, Iss , Pp 101134- (2022)
Introduction: We investigate the association neighborhood cohesion, as source of social support, has with psychological distress among white, Black, and Latinx lesbian, gay, and bisexual (LGB) individuals, compared to heterosexual individuals in the
Externí odkaz:
https://doaj.org/article/0eca968dd1784fb5982ec67111f355b0
Autor:
Kali R. Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M. Pimentel-Elardo, Jen L. Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, José F. Muñoz, Sang Hu Kim, John A. Porco, Christina A. Cuomo, Noelle S. Williams, Ashraf S. Ibrahim, John E. Edwards, David R. Andes, Justin R. Nodwell, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major effl
Externí odkaz:
https://doaj.org/article/2c173732359e4b30bf7d56530b8aca91
Autor:
Oshrat Levi-Galibov, Hagar Lavon, Rina Wassermann-Dozorets, Meirav Pevsner-Fischer, Shimrit Mayer, Esther Wershof, Yaniv Stein, Lauren E. Brown, Wenhan Zhang, Gil Friedman, Reinat Nevo, Ofra Golani, Lior H. Katz, Rona Yaeger, Ido Laish, John A. Porco, Erik Sahai, Dror S. Shouval, David Kelsen, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Expression and activation of Heat shock factor 1 (HSF1) in cancer associated fibroblasts have been associated with protumorigenic functions. Here the authors show that, in a model of colitis-induced colorectal cancer, HSF1 is activated in stromal fib
Externí odkaz:
https://doaj.org/article/e2082e39466448b09082f3deb8fc453c
Autor:
Sujoy Chatterjee, Shivraj M. Yabaji, Oleksii S. Rukhlenko, Bidisha Bhattacharya, Emily Waligurski, Nandini Vallavoju, Somak Ray, Boris N. Kholodenko, Lauren E. Brown, Aaron B. Beeler, Alexander R. Ivanov, Lester Kobzik, John A. Porco, Jr., Igor Kramnik
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102845- (2021)
Summary: Macrophages contribute to host immunity and tissue homeostasis via alternative activation programs. M1-like macrophages control intracellular bacterial pathogens and tumor progression. In contrast, M2-like macrophages shape reparative microe
Externí odkaz:
https://doaj.org/article/a1f35f552f1f482fb68b000a8206985c
Autor:
Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and gl
Externí odkaz:
https://doaj.org/article/5805d19b9df44bceaf4b4ac6e534ad64
Autor:
Luke Whitesell, Nicole Robbins, David S. Huang, Catherine A. McLellan, Tanvi Shekhar-Guturja, Emmanuelle V. LeBlanc, Catherine S. Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L. Xie, Damian J. Krysan, Susan Lindquist, John A. Porco, Utpal Tatu, Lauren E. Brown, Juan Pizarro, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstr
Externí odkaz:
https://doaj.org/article/c204109fbee74209af84981ef754b8a6