Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lauren E. Alfonse"'
Autor:
Colin McGaw, Anthony J. Garrity, Gabrielle Z. Munoz, Jeffrey R. Haswell, Sejuti Sengupta, Elise Keston-Smith, Pratyusha Hunnewell, Alexa Ornstein, Mishti Bose, Quinton Wessells, Noah Jakimo, Paul Yan, Huaibin Zhang, Lauren E. Alfonse, Roy Ziblat, Jason M. Carte, Wei-Cheng Lu, Derek Cerchione, Brendan Hilbert, Shanmugapriya Sothiselvam, Winston X. Yan, David R. Cheng, David A. Scott, Tia DiTommaso, Shaorong Chong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Cas12i is a genome editing platform with compact size that fits in AAV vector with short 43-mer gRNA, absence of tracrRNA, ability to process pre-crRNA, and high specificity. Here the authors present an unbiased mutational scanning approach to engine
Externí odkaz:
https://doaj.org/article/b34236ad23cc4e1cb4a7c8a576cc399b
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S16, Pp 1-12 (2019)
Abstract Background In order to isolate an individual’s genotype from a sample of biological material, most laboratories use PCR and Capillary Electrophoresis (CE) to construct a genetic profile based on polymorphic loci known as Short Tandem Repea
Externí odkaz:
https://doaj.org/article/0bafb71ed85b4be99c99378533ed4bc8
Autor:
Lauren E. Alfonse, Slim Karkar, Catherine M. Grgicak, Ken R. Duffy, Desmond S. Lun, Xia Yearwood-Garcia
Forensic DNA signal is notoriously challenging to interpret and requires the implementation of computational tools that support its interpretation. While data from high-copy, low-contributor samples result in electropherogram signal that is readily i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bdcacdb2f70905d3ec181f548ac605
https://mural.maynoothuniversity.ie/15202/
https://mural.maynoothuniversity.ie/15202/
Publikováno v:
Forensic Science International: Genetics. 32:62-70
DNA-based human identity testing is conducted by comparison of PCR-amplified polymorphic Short Tandem Repeat (STR) motifs from a known source with the STR profiles obtained from uncertain sources. Samples such as those found at crime scenes often res
Publikováno v:
Journal of Forensic Sciences. 62:308-316
In forensic DNA casework, the interpretation of an evidentiary profile may be dependent upon the assumption on the number of individuals from whom the evidence arose. Three methods of inferring the number of contributors-NOCIt, maximum likelihood est
Publikováno v:
BIBM
Objective: Interrogating multiple polymorphic Short Tandem Repeat (STR) locations by way of PCR and capillary electrophoresis (CE) is the chief technique by which laboratories determine whether an individual contributed their DNA to biological materi
Autor:
Lauren E. Alfonse, David R. Cheng, Elise Keston-Smith, Anthony J. Garrity, Jason M. Carte, Eugene V. Koonin, Pratyusha Hunnewell, Shaorong Chong, David Scott, Shanmugapriya Sothiselvam, Kira S. Makarova, Winston X. Yan
Publikováno v:
Science (New York, N.Y.). 363(6422)
Additional, diverse CRISPR systems CRISPR systems have been revolutionizing molecular biology. Mining the metagenomic database, Yan et al. systematically discovered additional subtypes of type V CRISPR-Cas systems. The additional Cas12 effectors disp
Autor:
Lauren E. Alfonse, Ulrich J. Monich, Ken R. Duffy, Viveck R. Cadambe, Catherine M. Grgicak, Muriel Medard
There are three dominant contributing factors that distort short tandem repeat profile measurements, two of which, stutter and variations in the allelic peak heights, have been described extensively. Here we characterise the remaining component, base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8232f710293a34a3d1e9a240116e5ad3
http://eprints.maynoothuniversity.ie/8190/
http://eprints.maynoothuniversity.ie/8190/