Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Lauren E Woodard"'
Autor:
Lauren E Woodard, Xianghong Li, Nirav Malani, Aparna Kaja, Robert H Hice, Peter W Atkinson, Frederic D Bushman, Nancy L Craig, Matthew H Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e42666 (2012)
Transposons are useful tools for creating transgenic organisms, insertional mutagenesis, and genome engineering. TcBuster, a novel hAT-family transposon system derived from the red flour beetle Tribolium castaneum, was shown to be highly active in pr
Externí odkaz:
https://doaj.org/article/5511c535cd80440f85ae9ef7d8b50f3c
Autor:
Lauren E Woodard, Annahita Keravala, W Edward Jung, Orly L Wapinski, Qiwei Yang, Dean W Felsher, Michele P Calos
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11367 (2010)
Hydrodynamic injection is an effective method for DNA delivery in mouse liver and is being translated to larger animals for possible clinical use. Similarly, phiC31 integrase has proven effective in mediating long-term gene therapy in mice when deliv
Externí odkaz:
https://doaj.org/article/0a326988daac475aac9372837cb05493
Autor:
Julie Bejoy, Justin M. Farry, Eddie S. Qian, Curtis H. Dearing, Lorraine B. Ware, Julie A. Bastarache, Lauren E. Woodard
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/3ea34a51afa1410786f56e51532aa9cd
Autor:
Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian, Lauren E. Woodard
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Background In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture of podocytes is crucial for modeling of diabetic nephropathy and genetic podocytopathies and
Externí odkaz:
https://doaj.org/article/0b55a744ffa147448725ac956f0458bf
Publikováno v:
J Am Soc Nephrol
AKI affects approximately 13.3 million people around the world each year, causing CKD and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal renal damage and regenerative therapies for AKI are not available. Human kidney
Autor:
Theresa A. Shapiro, Gary H. Posner, Nirbhay Kumar, Bryan T. Mott, Vandana Singhal, Lauren E. Woodard
Publikováno v:
Pharmaceuticals, Vol 2, Iss 3, Pp 228-235 (2009)
Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malariai
Externí odkaz:
https://doaj.org/article/73d88e2847ad49beab26f7b93ff74b1b
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 4, Pp 100898-(2021)
STAR Protocols, Vol 2, Iss 4, Pp 100898-(2021)
Summary Several kidney diseases including congenital nephrotic syndrome, Alport syndrome, and diabetic nephropathy are linked to podocyte dysfunction. Human podocytopathies may be modeled in either primary or immortalized podocyte cell lines. Human i
Autor:
Matthew H. Wilson, Jay A. Tischfield, Edward J. Weinman, Amrik Sahota, Thomas M. Beckermann, Lauren E. Woodard, Feng Sha, Talat Alp Ikizler, Ruth Ann Veach, Richard Welch
Publikováno v:
BMC Nephrology
BMC Nephrology, Vol 20, Iss 1, Pp 1-9 (2019)
BMC Nephrology, Vol 20, Iss 1, Pp 1-9 (2019)
Background Cystinuria is an inherited disorder of renal amino acid transport that causes recurrent nephrolithiasis and significant morbidity in humans. It has an incidence of 1 in 7000 worldwide making it one of the most common genetic disorders in m
Autor:
Jovana Maksimovic, Lauren E. Woodard, Sean B. Wilson, Felisha M. Williams, Joan Li, Alicia Oshlack, Sara E. Howden, Pei Xuan Er, Matthew H. Wilson, Melissa H. Little, Norseha Suhaimi, Jessica M. Vanslambrouck, Andrew Lonsdale
Publikováno v:
Kidney Int
All nephrons in the mammalian kidney arise from a transient nephron progenitor population that is lost close to the time of birth. The generation of new nephron progenitors and their maintenance in culture are central to the success of kidney regener
Publikováno v:
Plasmid
TcBuster is a hAT-family DNA transposon from the red flour beetle, Tribolium castaneum. The TcBuster transposase is of interest for genome engineering as it is highly active in insect and mammalian cells. To test the predicted catalytic triad of TcBu