Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lauren E Schefter"'
Autor:
Jennifer E. Adair, Mark R. Enstrom, Kevin G. Haworth, Lauren E. Schefter, Reza Shahbazi, Daniel R. Humphrys, Shaina Porter, Kenric Tam, Matthew H. Porteus, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 796-809 (2020)
In vivo tracking of retrovirus-tagged blood stem and progenitor cells is used to study hematopoiesis. Two techniques are used most frequently: sequencing the locus of retrovirus insertion, termed integration site analysis, or retrovirus DNA barcode s
Externí odkaz:
https://doaj.org/article/2ca949df16b442a8a0654694a05cea59
Autor:
Christopher W. Peterson, Jennifer E. Adair, Martin E. Wohlfahrt, Claire Deleage, Stefan Radtke, Blake Rust, Krystin K. Norman, Zachary K. Norgaard, Lauren E. Schefter, Gabriella M. Sghia-Hughes, Andrea Repetto, Audrey Baldessari, Robert D. Murnane, Jacob D. Estes, Hans-Peter Kiem
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 91-104 (2019)
Summary: Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We q
Externí odkaz:
https://doaj.org/article/4ca7ae8953f54b429b0918e4417bc4a9
Autor:
Kevin G. Haworth, Lauren E Schefter, Matthew H. Porteus, Shaina Porter, Daniel Humphrys, Mark Enstrom, Kenric Tam, Reza Shahbazi, Hans-Peter Kiem, Jennifer E. Adair
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 796-809 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 796-809 (2020)
In vivo tracking of retrovirus-tagged blood stem and progenitor cells is used to study hematopoiesis. Two techniques are used most frequently: sequencing the locus of retrovirus insertion, termed integration site analysis, or retrovirus DNA barcode s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c961cadd9510c8b4542517c43f1034e
https://pubmed.ncbi.nlm.nih.gov/32355868
https://pubmed.ncbi.nlm.nih.gov/32355868
Autor:
Dale L. Boger, Gabriella Sghia-Hughes, Christopher M. Glinkerman, Elizabeth Simpson, Guoli Shi, Raymond R. Carillo, Saritha S. D'Souza, Kip Hermann, Hans-Peter Kiem, Nina D. Timberlake, Scott A. Snyder, Lauren E Schefter, Jennifer E. Adair, Kevin G. Haworth, Byoung Y. Ryu, Brian P. Sorrentino, Olivia Garijo, Bruce E. Torbett, Igor I. Slukvin, Stosh Ozog, Alex A. Compton
Publikováno v:
Blood
Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic HSC resistance to modifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe627ca95d25d774eed5e2965968dee
https://pubmed.ncbi.nlm.nih.gov/31416800
https://pubmed.ncbi.nlm.nih.gov/31416800
Autor:
Olivier Negre, Christopher W. Peterson, Christopher T. Lux, Sowmya Reddy, Ray R. Carrillo, Clare Samuelson, Anai M. Perez, Sowmya Pattabhi, Stefan Radtke, Ciaran M. Lee, David J. Rawlings, Jennifer E. Adair, Gang Bao, Lauren E Schefter, Olivier Humbert, Hans-Peter Kiem, Andrew M. Scharenberg
Publikováno v:
Sci Transl Med
Reactivation of fetal hemoglobin (HbF) is being pursued as a treatment strategy for hemoglobinopathies. Here, we evaluated the therapeutic potential of hematopoietic stem and progenitor cells (HSPCs) edited with the CRISPR/Cas9 nuclease platform to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dfa251a63d59359f65e2a3c360cfc6
https://pubmed.ncbi.nlm.nih.gov/31366580
https://pubmed.ncbi.nlm.nih.gov/31366580
Autor:
Blake J. Rust, Gabriella Sghia-Hughes, Krystin K. Norman, Robert D. Murnane, Lauren E Schefter, Christopher W. Peterson, Hans-Peter Kiem, Jacob D. Estes, Stefan Radtke, Zachary K. Norgaard, Audrey Baldessari, Andrea C. Repetto, Martin E. Wohlfahrt, Claire Deleage, Jennifer E. Adair
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 13, Iss 1, Pp 91-104 (2019)
Stem Cell Reports, Vol 13, Iss 1, Pp 91-104 (2019)
Summary Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158eabb28189d7f1d6a485da0aac6c8e
https://pubmed.ncbi.nlm.nih.gov/31204301
https://pubmed.ncbi.nlm.nih.gov/31204301
Autor:
Jennifer E. Adair, Lauren E Schefter, Christina Ironside, Zachary K. Norgaard, Hans-Peter Kiem, Kevin G. Haworth
Publikováno v:
JCI Insight. 3
The genomic integration of HIV into cells results in long-term persistence of virally infected cell populations. This integration event acts as a heritable mark that can be tracked to monitor infected cells that persist over time. Previous reports ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca21865da6b9cd738c55ed42ae0a118
https://doi.org/10.1172/jci.insight.99127
https://doi.org/10.1172/jci.insight.99127
Autor:
Morgan A. Giese, Mark Enstrom, Lauren E Schefter, Zachary K. Norgaard, Hans-Peter Kiem, Jennifer E. Adair, Yan-Yi Chan, Stefan Radtke, Kevin G. Haworth
Publikováno v:
Science translational medicine. 9(414)
Hematopoietic reconstitution after bone marrow transplantation is thought to be driven by committed and multipotent progenitor cells followed by long-term engrafting hematopoietic stem cells (HSCs). Here, we observed a population of early-engrafting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0622186e7ee60d158364b5076c6b8ab6
https://pubmed.ncbi.nlm.nih.gov/29093179
https://pubmed.ncbi.nlm.nih.gov/29093179
Autor:
Christopher W. Peterson, Ciaran M. Lee, Olivier Negre, Christopher T. Lux, David J. Rawlings, Gang Bao, Anai M. Perez, Lauren E Schefter, Hans-Peter Kiem, Sowmya Reddy, Ray R. Carillo, Olivier Humbert, Andrew M. Scharenberg, Stefan Radtke, Jennifer E. Adair, Sowmya Pattabhi
Publikováno v:
Blood. 132:806-806
Beta-thalassemia and sickle cell disease are monogenic disorders that are currently treated by allogeneic bone marrow (BM) transplantation although the challenges of finding a suitable matched-donor and the risk of graft vs host disease have limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad463c32e885d429e799de555f11fe3
https://doi.org/10.1182/blood-2018-99-112996
https://doi.org/10.1182/blood-2018-99-112996
Publikováno v:
Molecular Therapy. 24:S113-S114
Previously published gene modified cell transplantation studies in nonhuman primate models have described several key features of hematopoietic reconstitution (Kim, S. et al., 2014 and Wu, C. et al., 2014). These studies applied either retrovirus int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed7340ff5778d23de6fe91747f94ea2
https://doi.org/10.1016/s1525-0016(16)33092-1
https://doi.org/10.1016/s1525-0016(16)33092-1