Výsledky vyhledávání - "Lauren E Boucher"

Akademický článek

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Autor: Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis

Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005763 (2016)

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg

Externí odkaz: https://doaj.org/article/18b88a00726d44659ebd19c6f7c84d1b

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Akademický článek

The bactofilin cytoskeleton protein BacM of Myxococcus xanthus forms an extended β-sheet structure likely mediated by hydrophobic interactions.

Autor: David M Zuckerman, Lauren E Boucher, Kefang Xie, Harald Engelhardt, Jürgen Bosch, Egbert Hoiczyk

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121074 (2015)

Bactofilins are novel cytoskeleton proteins that are widespread in Gram-negative bacteria. Myxococcus xanthus, an important predatory soil bacterium, possesses four bactofilins of which one, BacM (Mxan_7475) plays an important role in cell shape main

Externí odkaz: https://doaj.org/article/728b06e41de542da8900eb4f5a78b7f7

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Akademický článek

'Stapling' scFv for multispecific biotherapeutics of superior properties

Publikováno v: mAbs, Vol 15, Iss 1 (2023)

ABSTRACTSingle-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells. However, scFv domains exhibit lo

Externí odkaz: https://doaj.org/article/07a49e5767d741f0bc24b50e3af689e1

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Surface salt bridges contribute to the extreme thermal stability of an FN3 ‐like domain from a thermophilic bacterium

Autor: Christopher Negron, Wenting Ma, Alexey Teplyakov, Winnie Chan, Sandeep Somani, Thomas J. Malia, Lauren E. Boucher, Gary L. Gilliland, Jinquan Luo, Galina Obmolova, Steven Jacobs

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 90:270-281

This study uses differential scanning calorimetry, X-ray crystallography and molecular dynamics simulations to investigate the structural basis for the high thermal stability (melting temperature 97.5 °C) of a FN3-like protein domain from thermophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee132e201b802ca70f181b7d191acbf
https://doi.org/10.1002/prot.26218

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Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems

Autor: Michael J. Matunis, Anita Ramachandran, Xue Xia, Jürgen Bosch, Lauren E. Boucher, Katherine H. Reiter

Publikováno v: Journal of Biological Chemistry. 291:3860-3870

Protein modification by small ubiquitin-related modifiers (SUMOs) is essential and conserved in the malaria parasite, Plasmodium falciparum. We have previously shown that interactions between the SUMO E1-activating and E2-conjugating enzyme in P. fal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d825d14d361f7b774d9531006f721aa
https://doi.org/10.1074/jbc.m115.680801

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Discovery of Plasmodium (M)TRAP-Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion

Autor: Friedrich Frischknecht, Jürgen Bosch, Christine S. Hopp, Julianne Mendi Muthinja, Lauren E. Boucher

Publikováno v: ACS infectious diseases. 4(4)

As obligate, intracellular parasites, Plasmodium spp. rely on invasion of host cells in order to replicate and continue their life cycle. The parasite needs to traverse the dermis and endothelium of blood vessels, invade hepatocytes and red blood cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5787debc40be03ba8895ad3877433875
https://pubmed.ncbi.nlm.nih.gov/29411968

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Structure of Toxoplasma gondii fructose-1,6-bisphosphate aldolase

Autor: Jürgen Bosch, Lauren E. Boucher

Publikováno v: Acta Crystallographica. Section F, Structural Biology Communications

The structure of T. gondii fructose-1,6-bisphosphate aldolase, a glycolytic enzyme and structural component of the invasion machinery, was determined to a resolution of 2.0 Å.
The apicomplexan parasite Toxoplasma gondii must invade host cells t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b820d786dbbc24e9a6fb807e4198f0
http://europepmc.org/articles/PMC4157416

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Development of a multifunctional tool for drug screening against plasmodial protein-protein interactions via surface plasmon resonance

Autor: Jürgen Bosch, Lauren E. Boucher

Publikováno v: Journal of Molecular Recognition. 26:496-500

We have developed an expression system capable of producing large quantities of low cost, specific peptides that are either His12 -tagged, biotinylated, or unlabeled. The flexibility of this peptide system is suitable for interaction studies via surf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c7cc86b984949fb0a9a9ef8563f41e1
https://doi.org/10.1002/jmr.2292

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