Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lauren Duhamel"'
Autor:
Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical success has been limited by on-target, off-tumor activity. Here, we report the developmen
Externí odkaz:
https://doaj.org/article/8e65e3d9cba14ba3930a59f163a199fe
Autor:
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011138 (2024)
The presence of large protein inclusions is a hallmark of neurodegeneration, and yet the precise molecular factors that contribute to their formation remain poorly understood. Screens using aggregation-prone proteins have commonly relied on downstrea
Externí odkaz:
https://doaj.org/article/ff563c2f2e794dd693786fc7a6613821
Autor:
Emi A Lutz, K Dane Wittrup, Joseph R Palmeri, Brianna M Lax, Josh M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, William Pinney, Bryan D Bryson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1d4f4929a5304e66974b9d6a359dc8a4
Autor:
Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup
Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical development has been hampered by on-target, off-tumor toxicity. Here, we report the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c9a26a29bffbde5f9ff8ba4bf52371d
https://doi.org/10.1101/2023.01.30.526116
https://doi.org/10.1101/2023.01.30.526116
Autor:
Yan Gu, Nesredin Mussa, Sergey Voronov, Yuanqi Tao, Julia Ding, Lauren Duhamel, Zheng Jian Li, Gregory V. Barnett
Publikováno v:
Analytical and bioanalytical chemistry. 411(21)
Positive identification of capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) electropherogram peaks provides information to understand protein molecular characteristics at the structural level. It is critical in the design of a robust assay t
Autor:
Kelly Stone, Zheng Jian Li, Yunping Huang, Elizabeth Bigelow, Lauren Duhamel, Yuanli Song, Sanchayita Ghose, Ran Furman, Melissa Holstein, Jie Chen
Publikováno v:
Journal of Chromatography A. 1643:462008
Charge variants of biological products, such as monoclonal antibodies (mAbs), often play an important role in stability and biological activity. Characterization of these charge variants is challenging, however, primarily due to the lack of both effi